Researcher at @UU_university, Uppsala University. Comparative genomics with a focus on human/canine health.
Joined July 2020
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JenMeadows retweeted
Save the date! The Long-Read Uppsala Meeting will be back on October 21-23, with a great lineup of speakers. Abstract submission for oral and poster presentations will open during the spring.
More info and updates on the #LRUA24 website: lrua2024.se
JenMeadows retweeted
An encyclopedia of enhancer-gene regulatory interactions in the human genome
teapaw.org/argschwind/status/1724…
Very proud—4 years in the making, huge team effort.
This is a paper where the author list cannot convey everyone's incredible contributions.
My holiday highlights below:
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Excited to share our latest work on bioRxiv!
biorxiv.org/content/10.1101/…
A highly collaborative effort with @ksmualim @karbalayghareh, @mayayayas, @kanishkadey, @evelynjagoda,@WangXijhu, @LarsMSteinmetz, @anshulkundaje, @jengreitz and many others from @ENCODE_NIH!
Thread👇
JenMeadows retweeted
Our paper on long-read single-cell WGS is finally out!!🥳 We demonstrate that SNVs, SVs and TRs can be analyzed in individual human T-cells and present results of de novo assembly. Huge thanks to @joanna_hard and everyone involved! @scilifelab @ngisweden
nature.com/articles/s41467-0…
🐕Let the new analyses begin! 🐩 Proud to be a driver of the #Dog10K analysis of 2000 genomes, and to see the release of 48M variants, an #imputation panel, data harmonisation pipelines & more #dog #genomics @uppsalauni @scilifelab @KltLab genomebiology.biomedcentral.…
It's published! Whether you're interested in deciphering mammalian evolution, or driven to dissect the complexities of human health, the 11 papers in this special issue of @ScienceMagazine have you covered! Welcome to @ZoonomiaProject !
scim.ag/2oO
#Zoonomia
Placing the genetics of Swedish ankylosing spondylitis in a global frame. With thanks to our clinical and research partners @UU_University @scilifelab. New research published in @tandfonline doi.org/10.1080/03009742.202…
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Our new research in @FrontGenetics reveals a protective HLA-A locus in a Swedish HLA-B∗27 Positive Ankylosing Spondylitis population
Includes new @scilifelab community resource #SweGen1000genomes 17 MHC genes, genotyped at 2-field resolution
doi.org/10.3389/fgene.2021.6…
JenMeadows retweeted
led by @BrodinPetter (SciLifeLab/KI), researchers at @karolinskainst and @unitorvergata have mapped the immune response in children affected by MIS-C.
The results show that the inflammatory response in MIS-C differs from both Kawasaki and COVID-19.
bit.ly/3mnutr3
JenMeadows retweeted
New publication in @RheumJnl about the genetic and clinical basis for two subtypes of primary Sjögren’s syndrome. Led by Gunnel Nordmark at @UU_University this work is a team effort with the DISSECT consortium @JenMeadows8 @KltLab and plenty of others!
academic.oup.com/rheumatolog…
JenMeadows retweeted
To celebrate our upcoming 20-year anniversary, we commissioned a #Viewpoint in which 12 leading researchers reflect on 'The road ahead in genetics and genomics' rdcu.be/b6qQ5 #SharedIt
JenMeadows retweeted
A study published in Nature reports that melanoma cells that pass through the lymph nodes pick up a protective coating, allowing them to survive high levels of oxidative stress in the blood and go on to form distant tumours. go.nature.com/3hfbE6F
JenMeadows retweeted
Getting antibodies for ChIP-seq for some species can be a real challenge! We solved the problem by using tissue-specific biotinylation: no antibodies, no sorting, low cell numbers! Our protocol for #zebrafish and #chicken is now available @STARProtocols.
sciencedirect.com/science/ar…
JenMeadows retweeted
Our September 2020 issue is live: go.nature.com/3gTX4kS Topics include: gene regulatory programmes of tissue regeneration; transposon-insertion sequencing; haematopoietic stem cell self-renewal; histone methylation in genomic imprinting
Methylation and the molecular clock - "Quantitative Translation of Dog-to-Human Aging" doi.org/10.1016/j.cels.2020.…
Wow - ENCODE Phase 3 is here! Time to sit down with the issue and plan the new phase of comparative genetics & genomics!
ENCODE 3. A collection of research articles and related content describing the Encyclopedia of DNA Elements, its datasets and tools. nature.com/articles/d42859-0…
Great for news for the community! German shepherd (Mischka) long-read dog assembly released by UCSC.
We have updated assemblies for both dog (canFam4) and bonobo (panPan3). These assemblies were made available in March 2020 by the @UU_University (canFam4) and May 2020 by the Eichler Lab @UW (panPan3).
See our news for more: bit.ly/GB071020
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Excited to share a new annotated canine genome for the genomics community! Congratulations to the Uppsala team! #genomics #dogsofinstagram #uppsalauniversity
A new long-read dog assembly uncovers thousands of exons and functional elements missing in the previous reference biorxiv.org/cgi/content/shor… #bioRxiv
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