Associate Prof, Physiology, University of Manitoba and CHRIM. Understanding #T1D from the perspective of the beta cell

Winnipeg, MB, Canada
Joined February 2020
How are we learning from #T1D trials and moving towards precision medicine? Congrats 🎉to @pipellaj on writing a fantastic review on this topic Diabetes, Obesity and Metabolism! dom-pubs.onlinelibrary.wiley…... @DREAM_trainees
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TrialNet screens families of people with T1D & offers clinical studies testing ways to slow down & prevent disease progression. Our free at-home screening kits can be shipped anywhere in the US & Canada.
Type 1 diabetes (T1D) knows no boundaries—but access to screening and post-diagnostic care does. [1,2] Adolescents and young adults in rural communities are at greater risk of delayed diagnosis of T1D, often presenting with life-threatening diabetic ketoacidosis (DKA). [2] Research shows that living far from specialized care and lacking access to technologies can lead to worse health outcomes. [2] And these challenges don’t stop there—they’re compounded for those facing language barriers or financial hardships. [1,3] Research published in 2023 in the Journal of Pediatric Health Care found that delayed referral and diagnosis in rural areas negatively affected T1D management, creating health inequities. [2] This delay often stems from limited access to specialized care or awareness of T1D symptoms among primary care providers. [2] And a 2023 study published in Frontiers in Clinical Diabetes and Healthcare found that individuals with limited English language proficiency had a significantly higher HbA1c than those not needing an interpreter. [1] Language barriers and rural residence can correlate to lower health literacy, poorer glycemic control, and delayed interventions for T1D. [1] And it’s a double whammy when someone faces the simultaneous challenge of a language barrier and living in a rural setting. [4] We can do more, and we must do more, to bend these trends by advocating for vigilance in T1D, screening for those with potential risk AND advocating for clear, plain-language educational information and broader access to specialized care for those impacted. I’ve been engaged by Sanofi to highlight the importance of taking action to screen for T1D, what we can do to support patients who may be at risk, and when to advocate for them. Check out ScreenForType1.com [bit.ly/44dUlxw] for more information you can share with your patients, and tools in multiple languages!! Together, we can transform how T1D is diagnosed. Let’s make screening the new standard of care! #Sponsored #Sanofi_Partner #T1D #Type1Diabetes #screenforT1D #PaidPartner #HealthEquity #Type1Diabetes #ScreenForAll #EarlyDiagnosisMatters #InclusiveHealthcare #DEIinMedicine #T1DCommunity #EndHealthDisparities References 1. Idkowiak J, et al. Front Clin Diabetes Healthc. 2023;4:1228820. 2. Jewell VD, et al. J Pediatr Health Care. 2023;37(1):48-55. 3. Lin MH, et al. Diabetes Technol Ther. 2013;15(11):929-934. 4. Detz A, et al. J Gen Intern Med. 2014;29(12):1650-1656.
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Enjoyed an amazing @CIHR_IRSC @BT1D_CA in person team mtgand knowledge exchange event for our precision medicine in #T1D grant last week w/ this fantastic team!! @guy_rutter, @carapetop, Herb Gaisano, Fei Kang, Dana Greenberg, Pere Santamaria, Giada Ostinelli and Shadai Salazar
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Celebrating summer with a lab potluck- and we got everything! Who knew we were a #foodie lab? Grateful to work with this amazing group of people!😄👍🏿 ⁦@DREAM_trainees⁩ ⁦@CHRIManitoba⁩
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All type 1 diabetes researchers, physicians, care givers, and people with lived experience please retweet with important survey. We are halfway to our goal of 2000 responses. We hope the answers will help guide future research. Spread broadly for more diverse respondents.
Living with type 1 diabetes, or care for someone who does? @CORE_UBC, @SansumDiabetes , & @IPTN_Canada want to hear about your experience with #food & #dietstrategies. This 5-10min survey provides valuable information for the T1D community & researchers. ow.ly/SWyZ50Q9wSS
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Amazing to receive our first ever prep of #T1D donor islets from @AlbertaDiabetes @bcellorg today!! Immensely grateful & excited for what we can learn about survivor beta cells from this rare & precious gift!
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We're recruiting! Thompsonlab.ca @DREAM_diabetes @CHRIManitoba @umanitoba in #Winnipeg is seeking a talented postdoctoral scholar to work on mouse models to study beta cell stress and autoimmunity in #T1D for early 2024! Please RT!
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So proud 🥳🎉of my grad student @pipellaj as she delivered fantastic presentations of her work on anti-CD3 therapy in #T1D @DiabetesCanada vascular2023 and @CIRTNetwork 2nd annual meetings in beautiful #Montreal Well done!!
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Peter Thompson retweeted
Pleased to have contributed to this review for @Diabetologia led by @DrPeterThompson with #herbgaisano #peresantamaria and #jasminepipella to provide our take on the importance of beta cell heterogeneity in this context @CRCHUM @HIRN_CC @ImperialMDR
Thompson et al. advance the hypothesis that antigen presentation by beta cells, their stress responses, and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in #type1diabetes. link.springer.com/article/10…
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🚨We are looking to recruit PhD student(s) and postdoc fellow, to work on a very interesting project on the role vitamin K-dependent proteins in beta cell and diabetes! Follow up of our recent @CellReports paper. @CIHR_IRSC funded. @ircm_mtl Please RT. More info in the ad 👇👇
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Very grateful to receive the Allen Rouse Basic Science Career Award from the Manitoba Medical Services Foundation this year! 🎉 Excited to continue my career @CHRIManitoba @UM_RadyFHS @DREAM_diabetes
Congrats to Dr. Peter Thompson on receiving the 2023 MMSF Allen Rouse Basic Science Career Development Research Award! @CHRIManitoba
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Huge congrats👏🥳🎉 to my grad student Jasmine Pipella on her Canada Graduate Scholarship award (CGS-M)! So well deserved! Jasmine's project investigates anti-CD3 therapy during presymptomatic stages of #T1D and she is off to an amazing start! @CHRIManitoba @DREAM_trainees
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Thrilled to tackle questions around heterogeneity & precision med in #T1D! Grateful to lead team with @guy_rutter, Pere Santamaria and Herb Gaisano! Congrats🎉 & grateful to join team led by @EJRideout with @DSLuciani @JimJohnsonSci @BruceVerchere THX to all Patient Partners!
The goal of precision medicine is to get the right treatment to the right person at the right time. These grants, worth $3.5 million each, have been awarded to four teams across Canada! Learn More - ow.ly/l7uH50NjqGl
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Peter Thompson retweeted
Please consider submitting your work to this exciting collection! Deadline extended to March 10 ✅
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Thrilled and honoured to receive @DiabetesCanada funding for our project to delineate novel biomarkers and therapeutic targets for #senescence in human beta cells for the benefit of those affected by #T1D Congrats to @CIRTNetwork colleagues and others who also received funding!
We're thrilled to award $9M to 30 new research projects. Diabetes Canada funds some of the most renowned researchers in their quest for new developments in diabetes management, care, and risk-reduction that could lead to the next breakthrough. ow.ly/nb0Z50MsyWu
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Peter Thompson retweeted
Tomorrow! I’m going to be speaking in the UCLA virtual islet research group seminar, hosted by @VPoitout !! Will be talking about human islet cell phenotypes in T1D and T2D. Some published data and some new. Was I not supposed to fly to LA for this?? Here’s the info.