#author of #RAPIDOT and #Shifted, #art https://xitter.cf/t.co/OErVjMnsS3 composing #music https://xitter.cf/t.co/EobWSkCQoE

GERMANY, EUROPE, PLANET EARTH
Joined January 2017
#piano ‘Transformation’ by Cordula Sachse-Seeboth, August 2026 #SoundCloud on.soundcloud.com/xC0hcYdqRf…
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What a waste, to let a human soul live but once. Heaven counts its souls in stars. Quel gâchis que de laisser une âme humaine ne vivre qu’une seule fois ! Le ciel compte ses âmes en étoiles. 25 October 2026
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«If you wish to understand the universe, think of energy, frequency, and vibration» — Nikola Tesla
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Your walking speed after 80 might protect your brain more than crossword puzzles ever could. Researchers followed nearly 4,000 older adults and found something striking: The fastest walkers in their 80s, called “super movers." were about 50% less likely to develop cognitive decline than their slower peers. These weren’t elite athletes. They simply walked significantly faster than others their age (top 9%). And they preserved more hippocampal volume—the brain’s memory hub—even when some still showed Alzheimer’s-related plaques. Why does this matter? Walking pulls on muscle, balance, heart, lungs, and nerves at once. Contracting muscle releases BDNF, a key protein that supports neuron survival and brain growth. In short: muscle health is cognitive health. Genetics play a role, but lifestyle still matters. Nearly half of dementia cases are linked to modifiable factors. Limitations of study: Observational and focused on a relatively healthy older cohort. The practical takeaway is simple: Keep moving at a pace that challenges you. Consistency beats intensity. And don't forget to strength train too. What’s one movement habit you’re building this week to protect both body and brain? #BrainHealth #HealthyAging
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The main problem today? Nothing gets published without academic qualifications. Nor does it get published without having completed the ‘right’ degree course. A physicist rarely publishes primarily in medical journals, and vice versa. Who or what have we already missed out on?
121 years ago today, Einstein mailed in arguably the most famous equation. On September 27, 1905, a 26-year-old Swiss patent clerk with dark, curly hair – years before he grew that signature nest of white hair – dropped three handwritten pages in the mail. The paper arrived at the offices of Annalen der Physik, a German scientific journal. It had no university title attached. But inside, an idea would forever change how we understand the universe: E = mc² Energy equals mass times the speed of light squared. That single equation revealed something astonishing – that mass and energy are not separate things. They are different forms of the same stuff. A tiny amount of matter can release an enormous amount of energy, because the speed of light squared is such a massive number. This one insight explained how stars shine, how atoms split, how nuclear bombs work, and what happened in the first seconds after the Big Bang, when energy and matter were constantly trading places. Without E = mc², we wouldn’t understand modern cosmology, nuclear energy, or even the chemistry of stars. Einstein would go on to publish four other groundbreaking papers that year – covering light, time, motion, and atoms. Physicists now call it his miracle year. But this one, mailed 120 years ago today, reshaped our understanding of reality itself.
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Ultimately, it is somewhat ironic that, of all people, those who have done little to maintain their health end up living longer ‘by chance’ because they are receiving metabolism-rejuvenating drugs that are potentially of great interest in terms of #longevity
Late-life semaglutide treatment extended lifespan and improved physical and cognitive function in female mice.
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Engineers have taught a disembodied robotic hand to walk on its fingers, recover from falls, press keyboard keys, and manipulate objects without an arm. 🎥: softrobotics / YouTube #robots #robotics #technology #technews
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Most of our cells contain mitochondria and rely on them for signaling, information processing, energy transformation, and other essential functions. So when a genetic mutation affects mitochondria, the impacts can be broad and can impact each individual differently. When mitochondria aren't working properly, their impaired biology can manifest in morphological anomalies that we can see using electron microscopy. As we near the end of MitoMonth, I wanted to share some striking examples of what mitochondria can look like in individuals who have mitochondrial diseases. Those are mitochondria from the muscle of fellow human beings whose mitochondria can't flow energy properly—specifically, where electrons flow with greater resistance than usual in the electron transport chain. Are these the pictures of chronic excess energy resistance? Many of these images were captured by @AmyV91 and published in this paper: doi.org/10.1038/srep30610 We'll share more about mitochondrial diseases in a TSEE Substack post next week.
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The new treatment literally grows new neural connections in the brain. Researchers at the University of California, Davis, have developed a groundbreaking molecule that delivers the powerful brain-repairing benefits of LSD — without any hallucinations. By simply swapping two atoms in the LSD structure (what lead researcher David E. Olson playfully called a molecular “tire rotation”), the team created JRT — a non-hallucinogenic “neuroplastogen.” This innovative compound keeps LSD’s remarkable ability to stimulate neuronal growth and repair damaged synapses, while eliminating the psychedelic effects that make traditional LSD too risky for many patients. The results are impressive: in preclinical studies, JRT increased dendritic spine density by 46% and was nearly 100 times more potent than ketamine as an antidepressant. Crucially, it avoided the gene expression patterns and behaviors linked to psychosis. This could be a game-changer for psychiatric care — especially for people with schizophrenia and other conditions involving synaptic loss and brain atrophy, who were previously excluded from psychedelic-based therapies.
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I’m a scientist. I need to say this because the AI hype is getting ridiculous. AI can design a molecule in seconds. That doesn’t mean it discovered a drug. It discovered something we scientists have never been short of: Something to test. Someone still has to make it. Run the experiment. Measure whether it works. Check whether it’s toxic. And ultimately prove it works in the real world. AI hype tells us: “Prediction is discovery.” “Simulation is experimentation.” “Generating a molecule is developing a drug.” It isn’t. AI is making ideas incredibly cheap. But every new idea creates something AI cannot generate: Evidence. And the more hypotheses AI produces, the more experiments we’re going to need. That’s the irony nobody seems to be talking about. AI may not make laboratories obsolete. It may make them more valuable than ever. You can speedrun the thinking. You can’t speedrun reality.
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Computational processes take time, however brief they may be. It is fascinating to know what the temporal resolution of this universe is; perhaps it is the lower limit. #quantum #entanglement #time #universe #resolution #computational
⚛️ Scientists Just Caught Quantum Entanglement in Time Quantum entanglement has often been described as almost instantaneous. But scientists have now explored its development on an astonishingly tiny timescale — around 232 attoseconds. An attosecond is one billionth of a billionth of a second. Using ultrafast laser techniques and studying electrons in helium, researchers found that the quantum connection develops during the electron’s extremely rapid escape from the atom. It happens so fast that even light seems slow by comparison. And the mystery deepens: what other quantum processes that appear instantaneous might have a hidden timeline? Source: Jiang, W.-C., et al. (2024). Time delays as attosecond probe of interelectronic coherence and entanglement. Physical Review Letters, 133, 163201.
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Computational processes take time, however brief they may be. It is fascinating to know what the temporal resolution of this universe is; perhaps it is the lower limit. #quantum #entanglement #time #universe #resolution #computational
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We learn most effectively from the most painful experiences when we allow ourselves to come to terms with them, and even more so when we transform them into art
🧠 Your Brain May Be Learning From the Truth You Avoid Your brain is constantly making predictions. This will happen. They will react this way. I already know what to expect. But then reality surprises you. That gap between what you expected and what actually happened is called a prediction error—and it can act like a learning signal, helping the brain update its expectations. Now comes the fascinating part. When something feels uncomfortable, we may avoid it—ignore the feedback, walk away, or quickly defend ourselves. Avoidance can bring short-term relief, but repeated avoidance can also prevent us from learning that a situation may be safer or different than we expected. So sometimes, that uncomfortable moment is more than just uncomfortable. It may be new information your brain has been waiting for. When we can stay present and safely examine what challenges our expectations, we give the brain a chance to learn, update, and adapt. Growth may begin where certainty ends. Source:
Papalini, S., Beckers, T., & Vervliet, B. (2020). Dopamine: From prediction error to psychotherapy. Translational Psychiatry, 10, 164.
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Anthony James' artworks bring an impossible concept like the idea of infinity, or the cosmos, into physical objective existence. This is his Great Rhombicosidodecahedron in the permanent collection of the Palm Springs Art Museum
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🚨 SCIENTISTS JUST CREATED BATTERIES POWERED BY LIVING BACTERIA! What sounds like science fiction is becoming reality. Scientists are developing tiny batteries that generate electricity using living microbes. As the bacteria break down organic material, they release electrons that can be captured and turned into power. The technology is still in its early stages, but it could one day power sensors, medical devices, and remote equipment without traditional batteries. The biggest mystery? Some of these systems can even generate energy from ordinary soil. It may not charge your phone yet, but it could change the future of clean energy. Source: Fraiwan, A., & Choi, S. *Bacteria-Powered Battery on Paper*. Biosensors and Bioelectronics. Lee, H., & Choi, S. *An Origami Paper-Based Bacteria-Powered Battery*. Nano Energy.
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It would be interesting to examine the metabolic aspect by looking at surrogate markers of mitochondrial metabolism. This would allow the effects to be quantified more accurately and would reduce the influence of subjective factors.
A massive new meta-analysis @Nature of 67 datasets and over 8,000 people found that moving 🏃🏾‍♀️more in daily life is consistently linked to feeling more energetic, positive, and generally good. Interestingly, #physicalactivity was tied to feeling more energetic and positive but less calm, while it showed no reliable link to negative emotions like sadness or anxiety. The effects were comparable to other daily activities like listening to music, and they varied between people with older adults and those with higher BMI showing weaker positive emotional responses to activity. Movement and #mood appear to reinforce each other in everyday life, and understanding this loop could help shape more personalized health strategies. nature.com/articles/s41562-0…
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The greatest danger might not lie in an AI deciding to destroy humanity, but rather in several AIs escalating their conflict with one another in the name of different human objectives, thereby creating a system whose consequences are no longer controlled by any single AI.
Humanoid robots are now helping manufacture more humanoid robots. UBTECH has opened a new smart factory in China that can produce one robot about every 10 minutes. The facility uses robots, automated systems, and guided vehicles, with a stated capacity of around 10,000 robots annually.
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The greatest danger might not lie in an #AI deciding to destroy humanity, but rather in several AIs escalating their conflict with one another in the name of different human objectives, thereby creating a system whose consequences are no longer controlled by any single AI.
🤖 WILD: China just deployed a humanoid POLICE ROBOT alongside armed officers for patrols in Shenzhen. This video of EngineAI's T800 deployed in Nanshan District for community patrols is going viral.
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The fractal world of the chip. The universe repeats itself on both small and large scales
Apple Microchip CPU under a microscope. This is absolutely fascinating.
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The remarkable story of Chinese scientist Tu Youyou, who won the 2015 Nobel Prize in Physiology or Medicine for her discovery of artemisinin — a breakthrough drug that has saved millions of lives from malaria worldwide. In the late 1960s and early 1970s, amid China's "Project 523" (a secret effort to combat malaria during the Vietnam War era), Tu Youyou and her team reviewed thousands of ancient Chinese medical texts for herbal remedies against "intermittent fevers" (a classic description of malaria symptoms). Most preparations involved boiling herbs into decoctions, but one key reference from the Eastern Jin Dynasty (around 340 AD) stood out — Ge Hong's A Handbook of Prescriptions for Emergencies (肘后备急方). It described using qinghao (sweet wormwood, Artemisia annua) by taking "a handful of qinghao, immerse in two liters of water, wring out the juice, and drink it all." Notably, this method used cold water steeping and wringing (squeezing) rather than heat. This detail was pivotal: Traditional boiling methods had yielded inconsistent or ineffective results in modern tests because high temperatures degraded the active compound. Tu hypothesized that heat was destroying the antimalarial potency, so her team shifted to low-temperature extraction techniques. In September 1971, they experimented with solvents like ethyl ether (which has a low boiling point of about 35°C) to extract the leaves and stems at reduced temperatures. On October 4, 1971, they obtained a highly effective sample (#191) that achieved 100% inhibition of malaria parasites in rodent and monkey models. This led to the isolation of artemisinin (also called qinghaosu) in 1972. Tu even tested the safety of early extracts on herself first. Artemisinin-based combination therapies (ACTs) are now the WHO-recommended first-line treatment for malaria, dramatically reducing deaths, especially in Africa and Asia.
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