Quad-barrel piezo-driven fast solution exchange youtu.be/S5mM18imNOA?si=nGsa… via @YouTube pure art
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Take-home messages：
1: Stop treating CIPN as only hyperexcitability. Protect axonal energy supply.
2: Timing matters. After chemo starts, the window may already be closing.
3: Protection runs through 5-HT2A/TrkB, not the trip. Non-hallucinogenic agonists are the next test.
A psychedelic compound best known for its effects on the brain may help prevent one of chemotherapy's most debilitating side effects—chemotherapy-induced peripheral neuropathy, researchers report in Science.
In mouse models, as few as two doses of psilocybin given before treatment durably prevented CIPN through multiple cycles of chemotherapy, while preserving both nerve function and the therapies’ tumor-killing effects.
📄: scim.ag/4ctTNaF
#SciencePerspective: scim.ag/466LJcj
interesting, just asked the Editorial Office for high-res figures to verify data quality after they emailed me the other two reviewers submitted reports already. Within hours, received a polite email that my participation was 'no longer required' and the assignment was revoked😅
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If I understand it correctly, functional assays like patch clamp recording remain the gold standard
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Recovering. Shocked how my phone knows my activity so well. And the data shows the trending so clearly!#SmartphoneKnowsBest
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Interesting
C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway biorxiv.org/cgi/content/shor… #biorxiv_neursci
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C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Published today:
Finding the truth in science
In a ‘publish or perish’ culture, some scientists may resort to questionable research practices or even fraud.
nature.com/articles/s41568-0…
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One week to go until our next WWNav lecture given by Prof. Irina Vetter from Brisbane. Dont miss this opportunity to learn about toxins and sodium channels. Join the discussion! November 29th at 10am EDT/EST, 4pm CEST/CET sodiumchannelseminars.org @SwissIonChannel @IamshanovaO
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In this week's issue: With a growing number of people living with pain, we desperately need to understand it - here's where the science is and what it can do for those suffering
Grab a copy at newsstands or download our app for digital and audio editions
newscientist.com/issue/3413/
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Strongly suspected this might be the case as the connection keeps popping up in our studies. Very interesting! #cancer #nociceptors nature.com/articles/s41586-0…
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Cisplatin: Not just peripheral neuropathy? Read on recent findings of the implication of cisplatin adminstration on spinal motor neurons and the medullary inhibitory system. #chemotherapy #neuroscience #cancer #pharmacology link.springer.com/article/10…
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Two more days to go! Oct 25th - Bill Catterall on the next WWNavSeminar. Come and join us!
With @SwissIonChannel @IamshanovaO JannisKörner.
After the seminar is before the seminar - it is with great pleasure that we can announce Prof. William Catterall as the next speaker in our WWNavSeminarSeries sodiumchannelseminars.org on October 25th. Come and join his talk on Nav structure and their link to disease.
