Postdoc scientist @hdtbio interested in vaccine design, antibody discovery, and global health.
Seattle
Joined April 2020
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Amazing chikungunya fusion vid via the Kelly Lee/Iwasa labs. Hoping to see more cool fusion protein structure/dynamics work at this Physical Virology GRC/GRS. Apply here tinyurl.com/yckm8sv3 #cryoEM @GordonConf @selivanovitch @janetiwasa @MargotRiggi
Edgar Hodge retweeted
US President Donald Trump is calling for health officials to split up combo vaccines targeted at multiple diseases into individual jabs spread out over time, starting with the MMR shot. Here's the scientific evidence that explains why it's a bad idea.
go.nature.com/4zdzacD
Our new paper shows a rapid pipeline from repRNA VLP immunization to RNA-encoded VHH-Fc therapeutics with in vivo protection (EV-D68).
A unified platform for faster antiviral responses:
cell.com/molecular-therapy-f…
#RNAtherapeutics #Biotech
Edgar Hodge retweeted
The unfounded move by @HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today @Nature
Adds to successful pancreatic, renal cell, melanoma reports
nature.com/articles/s41586-0…
Edgar Hodge retweeted
Robert F. Kennedy Jr announced that the US federal government is terminating US$500 million worth of grants for mRNA vaccine research.
We must never, ever, forget that millions are alive today, or in better health, because of this life-saving technology.
go.nature.com/3HDCS9n
Edgar Hodge retweeted
A large study including more than 130,000 people in the U.S. revealed that the shingles vaccine (Shingrix) and the respiratory syncytial virus (RSV) vaccine (Arexyv) are associated with a reduced risk of dementia.
sciencealert.com/huge-study-…
Edgar Hodge retweeted
The U.S. Is Not Ready for Bird Flu in Humans
"Bird flu is infecting more people than we think. We need to stop it now before a new pandemic begins."
Scientific American
scientificamerican.com/artic…
Edgar Hodge retweeted
Resource on state economic activity & jobs that will be affected by $4B cut to NIH funding of research institutions-click on your state to see the impact #NIH #indirects unitedformedicalresearch.org…
Edgar Hodge retweeted
“It will be much easier to destroy the world’s greatest scientific ecosystem than it will be to try to rebuild it”
Scientists are worried about the long-term effects of the Trump administration’s actions
go.nature.com/40NZV8d
Edgar Hodge retweeted
We sequenced the anti-RSV-F antibody 131-2a by mass spec, then mapped its epitope by cryoEM. It's widely used to study the antigenic landscape of F, but its seq wasn't known. Check it out in our new preprint and find it on Addgene
biorxiv.org/content/10.1101/…
addgene.org/Joost_Snijder/
Edgar Hodge retweeted
Staff from across @statnews came together to deliver this story on what Trump and RFK Jr. can do on health care — and what might be out of bounds statnews.com/2024/11/09/trum…
Edgar Hodge retweeted
Cool paper by Mike Guttman’s group:
Direct Mapping of Polyclonal Epitopes in Serum by HDX-MS pubs.acs.org/doi/10.1021/acs…
Edgar Hodge retweeted
Our CCHF and NiV programs continue to hit milestones. Looking forward to continued success!
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Edgar Hodge retweeted
It's out in Cell!!! Super proud bug- and structural virologist moment; my paper about using CryoEM to discover, diagnose, characterize, and mitigate a nationwide agricultural pandemic is now published online 😄🐛🪲
cell.com/cell/fulltext/S0092…
Edgar Hodge retweeted
🧵 New in @ScienceTM and on the cover! science.org/doi/10.1126/scit… After developing RNA vaccines for several different enveloped viruses, we realized that no one had done so for nonenveloped viruses. In this paper, we sought to do just that, with a focus on a prototype picornavirus.
Edgar Hodge retweeted
Developing new drugs? Tired of SPR datasets where 50% of the results are inaccurate and/or suspect? Want more information faster?? Give 'quant' HDX a try! ++Work by PhD grad Esther Wolf with a great system and expertise by @CherylArrowsmi1 and @sackloo 🧵: pubs.acs.org/doi/full/10.102…
Edgar Hodge retweeted
Ok, we may have been but one cog in the wheel for this one, but we're a pretty nice cog and it's an awesome wheel, so... Witness the power of HDX wielded to reveal 'degrader' mechanisms! Collab with @vee_chow and @CherylArrowsmi1 and the SGC in Toronto: nature.com/articles/s41589-0…
Edgar Hodge retweeted
Awesome collaboration with the @McGuire_Lab now published! Use of @hdtbio’s LION/repRNA platform to prevent #EBV infection of humanized mice. nature.com/articles/s41541-0…
Edgar Hodge retweeted
With the recent news in thread below, it finally feels good to share results from our former/current partner who recently published phase 2/3 results of their vaccine based on our LION/repRNA technology in @NatureMedicine. nature.com/articles/s41591-0…
Edgar Hodge retweeted
HDT Bio recently spoke to Moira Gunn of @biotechnation to discuss the company’s progress in #RNAvaccine development and walk her through how our revolutionary repRNA/ LION™ platform works.
Listen here: bit.ly/44k4g3h
Edgar Hodge retweeted
Our new paper on cyclic ion mobility for HDX-MS is now out. Congrats to Damon for excellent work and thanks to Waters for continuing support. pubs.acs.org/doi/10.1021/acs…
