Emil Christensen (@EmilChristens) profile picture

Emil Christensen

@EmilChristens

Post doc at Department of Molecular Medicine, AUH, Denmark. Focus on bladder cancer, circulating tumor dna, cancer genomics, tumor evolution.

 Aarhus, Danmark
Joined March 2017
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  • Followers58
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Photo by Emil Christensen (@EmilChristens)
Very intriguing results!!
Tom Powles (@tompowles1) profile pictureTom Powles
@tompowles110 Dec 2020
ctDNA positivity after cystectomy for muscle invasive bladder cancer identifies a high risk of relapse. These patients have a survival benefit with adjuvant atezolizumab. ctDNA-ve patients have low risk of relapse and don’t benefit from atezo. ctDNA clearance in ~20 #ESMOImmuno20
Image from Tom Powles (@tompowles1)
Image from Tom Powles (@tompowles1)
Image from Tom Powles (@tompowles1)
Image from Tom Powles (@tompowles1)
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Emil Christensen retweeted
Lars Dyrskjøt (@LDyrskjot) profile picture
Lars Dyrskjøt@LDyrskjot23 Oct 2020
1/33 – What is the biological framework in patients responding to chemotherapy – and can we find predictive markers of response? We set out to explore this in our paper in @NatureComms rdcu.be/b7HAb @AnnTaber6 @EmilChristens @PhilippeLamy6 @AUHdk @moma_dk #tweetorial
Image from Lars Dyrskjøt (@LDyrskjot)
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The effect of surgical trauma on circulating free DNA levels in cancer patients—implications for studies of circulating tumor DNA #ctDNA #cfDNA buff.ly/2PSmrHE @Karin_Dem @MGogenur @IsmailGogenur @LDyrskjot @ClausLindbjerg @AarhusUni @NateraGenetics
Image from Molecular Oncology (@MolOncology)
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Emil Christensen retweeted
Lars Dyrskjøt (@LDyrskjot) profile picture
Lars Dyrskjøt@LDyrskjot23 Jun 2020
Happy to share a pre-print of our multi-omics UROMOL2020 work on non-muscle invasive bladder cancer. Discovery of 4 transcriptomic classes, linked to genomics and spatial proteomics. #NMIBC #bladdercancer medrxiv.org/content/10.1101/…
Image from Lars Dyrskjøt (@LDyrskjot)
Image from Lars Dyrskjøt (@LDyrskjot)
Image from Lars Dyrskjøt (@LDyrskjot)
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Happy to publish our results on surgical trauma affecting cell-free DNA levels in @MolOncology. Spoiler: Think twice before collecting blood samples! Read more: pubmed.ncbi.nlm.nih.gov/3247…. Thank you for the collaboration to all my co-authors! @ClausLindbjerg @moma_dk @CtdnaDK
The effect of surgical trauma on circulating free DNA levels in cancer patients-implications for...

The effect of surgical trauma on circulating free DNA levels in cancer patients-implications for...

Detection of circulating tumor DNA (ctDNA) post-treatment is an emerging marker of residual disease. ctDNA constitutes only a minor fraction of the cell-free DNA (cfDNA) circulating in cancer...

pubmed.ncbi.nlm.nih.gov
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Can ctDNA guide #immunotherapy in patients with advanced #bladdercancer? Prof. @LDyrskjot from @moma_dk has received 2.35 mil DKK from @cancer_dk to investigate this in the TOMBOLA trial. 👉bit.ly/2ZGnYHa @AUHdk @Rigshospitalet @HerlevGentofte @AalborgUH @OUHhospital
Image from Dept. of Molecular Medicine (@moma_dk)
Image from Dept. of Molecular Medicine (@moma_dk)
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MAY ISSUE | Review by @JoshMeeks et al. on heterogeneity in #BladderCancer: discussing tumour evolution, genomics, subtypes & variant histology and their influence on treatment decision making, drug development and trial design -> rdcu.be/b3lzA FREE to read
Image from Nature Reviews Urology (@NatRevUrol)
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Emil Christensen retweeted
Bernie Bochner, MD (@bbmdmsk) profile picture
Bernie Bochner, MD@bbmdmsk9 Dec 2019
Pathologic germline variants found in 14% of #bladdercancer pts @sloan_kettering Younger pts at even higher risk (22%) ! Strong data to support regular germline testing particularly younger patients. doi.org/10.1200/JCO.19.01395 @UroOnc @UrologyMSK @AmerUrological
Cancer Susceptibility Mutations in Patients With Urothelial Malignancies

Cancer Susceptibility Mutations in Patients With Urothelial Malignancies

PURPOSEUrothelial cancers (UCs) have a substantial hereditary component, but, other than their association with Lynch syndrome, the contribution of genetic risk factors to UC pathogenesis has not...

ascopubs.org
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Great work with interesting new insights!
Uromigos (@Uromigos) profile pictureUromigos
@Uromigos4 Nov 2019
Sequential tissue analysis after neoadjuvant atezolizumab shows dynamic changes with therapy. Baseline activated T cells predict response. Up regulation of fibroblast (FAP) and cell cycle genes predict resistance. TMB and PD-L1 seem less relevant nature.com/articles/s41591-0…
Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial...

Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial...

Nature Medicine - A single-arm multicenter phase 2 trial demonstrates clinical efficacy of neoadjuvant PD-L1 blockade in patients with resectable muscle-invasive bladder cancer ineligible for...

nature.com
Nu kan forskerne gå i gang 👍 25 mio. kr. fra #knækcancer går til nationalt forskningscenter for behandling vejledt af kræft-DNA i blodet #forskning #dkforsk #kræft #sundpol @ClausLindbjerg @LDyrskjot @AUHdk @DCCCcancer cancer.dk/nyheder/25-mio-kr-…
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Se med på mandag 21.10. kl 8.30 når TV2 Go' Morgen Danmark sender live fra MOMA @moma_dk i anledning af @KnaekCancer ugen. Prof. @ClausLindbjerg interviewes om det planlagte nationale forskningscenter for behandling vejledt af kræft-DNA i blodet. bit.ly/32utPxX
Image from Dept. of Molecular Medicine (@moma_dk)
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Emil Christensen retweeted
Aarhus Uni.hospital (@AUHdk) profile picture
Aarhus Uni.hospital@AUHdk4 Jun 2019
Ny forskning fra @AUHdk og @AarhusUni : Ny test for kræft-DNA i blodet kan målrette behandling af patienter med blærekræft. Næste skridt er afprøvning af immunterapi som behandling bit.ly/2wCy24i #sundpol #sundhed #dkvid @moma_dk @LDyrskjot
Image from Aarhus Uni.hospital (@AUHdk)
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Cell-free DNA analysis for monitoring relapse and treatment efficacy in urothelial bladder cancer, by @LDyrskjot @AarhusUni & colleagues bit.ly/2H7pEhI #blcsm
Image from Journal of Clinical Oncology (@JCO_ASCO)
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Very excited to see our recent ctDNA results online!
Lars Dyrskjøt (@LDyrskjot) profile pictureLars Dyrskjøt@LDyrskjot6 May 2019
Our recent ctDNA results are now online. In a prospective study we show that plasma DNA identifies early relapse and correlates with treatment response in bladder cancer: ascopubs.org/doi/abs/10.1200… @Karin_Dem @EmilChristens @JBjerggaard @NateraGenetics @AUHdk @AarhusUni
Image from Lars Dyrskjøt (@LDyrskjot)
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#NEWinNRU @LDyrskjot discusses the results of a large genomic comparison study of #UTUC and #BladderCancer in this News&Views go.nature.com/2BcphAo
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Our new paper on targeted sequencing of cell-free DNA from bladder cancer patients is out! rdcu.be/FTrD
Image from Emil Christensen (@EmilChristens)
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Emil Christensen retweeted
Lars Dyrskjøt (@LDyrskjot) profile picture
Lars Dyrskjøt@LDyrskjot1 Dec 2017
RNA circles in bladder cancer: Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer nature.com/articles/s41525-0…
Image from Lars Dyrskjøt (@LDyrskjot)
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Emil Christensen retweeted
Lars Dyrskjøt (@LDyrskjot) profile picture
Lars Dyrskjøt@LDyrskjot26 Sep 2017
Our paper on ctDNA analysis for monitoring relapse and treatment response in #bladdercancer is now online
Image from Lars Dyrskjøt (@LDyrskjot)
Image from Lars Dyrskjøt (@LDyrskjot)
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Emil Christensen retweeted
Videnskab.dk (@videnskabdk) profile picture
Videnskab.dk@videnskabdk16 Aug 2017
Ny blodprøve kan opdage kræft, før du får symptomer videnskab.dk/krop-sundhed/ny… #dkvid #dksund #sundpol @AarhusUni @AUHdk @Rigshospitalet
Image from Videnskab.dk (@videnskabdk)
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Emil Christensen retweeted
Lars Dyrskjøt (@LDyrskjot) profile picture
Lars Dyrskjøt@LDyrskjot3 Jun 2017
Prognostic Impact of a 12-gene Progression Score in NMI #bladdercancer - a prospective validation study (UROMOL) europeanurology.com/article/…
Image from Lars Dyrskjøt (@LDyrskjot)
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