Cardio-Immunologist, Macrophages. Associate Prof, Univ of Toronto. UHN. Research Director Peter Munk Cardiac Center. Loretta Rogers Chair. #Cardioimmunology
Toronto, Ontario
Joined October 2013
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Slava Epelman retweeted
Early signals for a selective new immunotherapy: invikafusp alfa activates Vβ6/Vβ10 T cells in treatment-resistant solid tumours. START-001, in Nature Medicine, co-led at Princess Margaret by Dr Lillian Siu. Early, small numbers — larger studies needed.
Slava Epelman retweeted
New paper alert!! Here we show in patient blood samples and animal models that Doxorubicin directly rewires CD8 T-cells into “matrix remodeling T-cells” or “mx-Tcells”allowing them to stiffen cardiac collagen directly through a Lox dependent mechanism
sciencedirect.com/science/ar…
Slava Epelman retweeted
Just published @Nature
A 3-agent AI personal health agent exceeded performance of a large language model/chatbot and serves as a foundation to build on for integrating sensor data, medical knowledge and coaching
nature.com/articles/s41586-0…
Slava Epelman retweeted
In mammals, there is no damage accumulation, there is only impaired regeneration capacity.
One of the most interesting findings was a population of Arg1-positive macrophages.
These macrophages were activated in regenerating #young tissues but their activation was suppressed in #aged regenerating tissues.
Decoding aging-dependent regenerative decline across tissues at single-cell resolution: Cell Stem Cell cell.com/cell-stem-cell/full…
Slava Epelman retweeted
山中因子とは違うRejuvenation因子の単離は色んな企業やアカデミアが実施していて、我々のOne Genomicsもこの論文のChurch博士と進めている
っていうのを色々書こうと思ったんだけど、Nature Agingって、インパクトファクター25もあるのね…。驚愕
最初16とかで、まぁそんなもんか、思ってたけど、これが商業の力か。
nature.com/articles/s43587-0…
Slava Epelman retweeted
New preprint from the lab: "A Compact Regulatory Logic Governs Fibroblast Cell State Plasticity in Fibrosis". We integrated mouse and human epigenomic data to identify 280 fibroblast disease-activated enhancers, then perturbed them by CRISPRi CROP-seq. 🧵
biorxiv.org/content/10.64898…
Slava Epelman retweeted
An absolute pleasure to be with my better half at #CCC 2026 while she presented her work on heart failure discharge criteria and compliance.
Slava Epelman retweeted
Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions
cell.com/immunity/fulltext/S… @ImmunityCP
Slava Epelman retweeted
Microplastics are chemically active, enable spontaneous •OH generation in water, and "have direct
implications for biomolecular adsorption, protein aggregation, and even cellular damage."
@Nature nature.com/articles/s41586-0…
Slava Epelman retweeted
Aging clocks, here with metabolites, are remarkably predictive of future health outcomes (top graph) and are telling about an individual's lifestyle factors (bottom graph)
new @ScienceTM
science.org/doi/10.1126/scit…
Slava Epelman retweeted
Our latest study suggests colchicine may improve LV recovery after acute myocarditis. Encouraging to see RCTs underway, including ARGO and CMP-MYTHiC, to establish its role. @Sukruth__K @_antocannata @Kings_BHFCentre #myocarditis ❤️🔥
eur03.safelinks.protection.o…
Slava Epelman retweeted
It's late 2026 and we still don't have a way to assess a person's immune system status in the clinic, the underpinning of healthy aging. But soon there may be at least 3 ways!
erictopol.substack.com/p/a-t…
Slava Epelman retweeted
Out now in Nature Medicine: a health-system-scale cachexia atlas (52K patients) that describes and predicts outcomes, with prospective risk models for lung, colorectal, and prostate cancer. Congrats to @EdReznik for a landmark paper for the field. nature.com/articles/s41591-0…
Slava Epelman retweeted
🧵 Biohub, @ENERGY, @NIH, and new funding partners today announced a major expansion of an international effort to generate and make accessible the data enabling predictive AI models of biology. Together, the organizations are investing $1.8 billion in funding, data, computation and new measurement technology - largest coordinated commitment to map the biology of the cell to power development of digital models of biology. bit.ly/3UhjoxD
Slava Epelman retweeted
A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
cell.com/immunity/fulltext/S…
Slava Epelman retweeted
Delighted to share RNA fingerprinting, out today in @CellCellPress! Together with @david_a_knowles , we use Perturb-seq experiments—where the causal perturbation is known—to infer what drives cellular responses in new datasets: cell.com/cell/abstract/S0092…
Slava Epelman retweeted
Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial–immune cell interactions @NatImmunol @hostmicrobe
@PennVet
nature.com/articles/s41590-0…
Slava Epelman retweeted
Unfortunately, the medical community has a singular view of the basis of coronary artery disease—lipids. But we keep seeing ways that heart attacks can occur independent of any lipid abnormality, like this one
New @CellCellPress
cell.com/cell/fulltext/S0092…
Slava Epelman retweeted
In @Nature: @teichlab confirms increased tissue resident macrophage density in the ♥️ conduction system, with focus on developing sinus node: rdcu.be/xKJaxsBHrtHa
Please see screen shots from @MaartenHulsmans paper: cell.com/cell/fulltext/S0092…
But what are these macs doing 🤔
Slava Epelman retweeted
We are funded!!! And hiring at Purdue and Broad!
JT Neal received an NIH Director’s Transformative Research Award for Project Encore. We'll test 1.6M+ drug-disease combinations in parallel using imaging, to repurpose drugs for rare genetic conditions
linkedin.com/feed/update/urn…
