Changes in tumor gene expression from early to late tumors concentrated on the suppression of genes that promote tumor recognition by innate and adaptive immune cells, rather than on changes in the expression of genes that promote tumor-cell-intrinsic malignancy (Fig. 1b) 12/18.

We performed scRNA-seq of tumor tissue harvested one week and one month after Her2 oncogene induction to characterize ‘early’ and ‘late’ tumors, respectively (Fig 1a). Bioinformatic analysis was used to identify key pathways in which gene expression changed significantly, (9/18)

We compared the transcriptome, epigenome and chromatin accessibility of Dictyostelium, one of the rare organisms that transits back and forth between unicellular and multicellular stages, with S. pombe and C. elegans to identify an epigenetic signature of multicellularity 2/7