Assistant Professor @MountSinai_Path & @IcahnMountSinai. #IBD Genetics #Crohn's #Innateimmunity #Zebrafish #Precisionmedicine. Comments of my own.
Manhattan, NY
Joined October 2017
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🧬 New on #bioRxiv: #GMCSF shapes #immune niches in #Crohn’s disease. #Singlecell spatial #transcriptomics + #zebrafish injury model show GM-CSF restrains #ILC1s, sustains #ILC3s, boosts IL-22, and limits #ulceration. #IBD biorxiv.org/content/10.64898…
Ling-shiang (Felix) Chuang, Ph.D. retweeted
The nuclei of the cells in the heart of a zebrafish embryo photographed through a microscope. The ventricle is on the left and the atrium is on right. #CellBiology
🎄✨ Merry Christmas! 🎅🏻 Wishing you all a day filled with love, laughter, and the warmth of cherished moments. May your hearts be as full as your plates and your spirits as bright as the twinkling lights.
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Apply for an exciting opportunity to visit the Kawakami Lab through the National Institute of Genetics Travel Grants. The deadline for the application is December 1, 2023 (Japanese time). Learn more about this grant and apply here: nig.ac.jp/nig/research-infra…
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Imaging the endocardium of the heart in a two-day-old zebrafish embryo. Credit to @Anjalie_Sch. #ZebrafishZunday
Ling-shiang (Felix) Chuang, Ph.D. retweeted
A time lapse of a cell going through cell division hand drawn by Walther Flemming while he was looking in his microscope in the 1800's. He chose to highlight the dynamics of chromosomes.
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Our mesoscopic oblique plane microscope is online:
opg.optica.org/optica/fullte…
It enables rapid volumetric imaging of a whole zebrafish embryo with ~2.3 micron lateral resolution.
This is enabled by merging a couple of optical innovations and tricks. 1/N
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Where do #TissueTregs come from? The previous standard model is the "seeding and specialisation" model, where #Tregs enter from tissues, turn on a dedicated transcriptional program per #tissue, and dwell indefinitely in that tissue as specialised cells.
1/3
Ling-shiang (Felix) Chuang, Ph.D. retweeted
FDA Approves Mirikizumab, a Promising Induction and Maintenance Therapy for Ulcerative Colitis. Offers new option with improved quality of life for patients with moderate-to-severely active disease mountsinai.org/about/newsroo…
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Simultaneous tracking of 100 zebrafish larvae using open-source software. Credit to @FastTrackOrg. #ZebrafishZunday
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Immune cells surveil the skin in an adult zebrafish explant. Credit to @errricpeterman. #ZebrafishZunday xitter.cf/errricpeterman/status/…
Ling-shiang (Felix) Chuang, Ph.D. retweeted
🤯
Mast cells function uncovered!
Mast cells link immune sensing to antigen-avoidance behaviour
#Nature nature.com/articles/s41586-0…
Ling-shiang (Felix) Chuang, Ph.D. retweeted
#GUTImage from the paper by Hsu et al entitled
"NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures" via
bit.ly/3l2f5oi
@mountsinaiIBD @shikha_nayar @Felix_Chuang240 @JudyCho7 #NOX #TNFa #IBD
Our new paper is out @Gut_BMJ today. ROS is crucial for maintaining epithelial stem cells. Lossing ROS results in #M cell expansion and basal #lymphoplasmacytosis.
New publication @Gut_BMJ: NOX1 is essential for #TNFα-induced #intestinal #epithelial #ROS secretion and inhibits M cell signatures. Congratulations to all authors @Naiyunhsu1 @JudyCho7 @Felix_Chuang240 @shikha_nayar @mabes_nyc @TStappenbeckMD @a_azabdaftari
Ling-shiang (Felix) Chuang, Ph.D. retweeted
#glycotime
This is a substantial achievement👏
Massive congratulations 🎊 🎉 to all authors:
@nkg2d1
@Felix_Chuang240
@JeanFredericCo1
@JudyCho7
@ZhiChai_Sinai
@JoanaTo62523004
@MiriamMerad
@Salome_S_Pinho
@effiken
@petra_fra
@SiuLingTai
@gaifem_joana
@Ines_S_Alves
@Cat__Azevedo
Seeing this out in @AGA_Gastro makes me so very proud! Our international team reports that anti-GM-CSF autoantibodies (aGMABs) are a predictive marker for Crohn’s Disease (CD) and neutralize GM-CSF years prior to diagnosis. tinyurl.com/yckpe87f
@AmerGastroAssn 1/7 👈😀
Ling-shiang (Felix) Chuang, Ph.D. retweeted
Come work with meeeeeeeeee!
We're hiring!! 🧑💼We are looking for a locum editor to join our team for a 6-month position, to be based in New York, Shanghai or London. We're particularly looking for applicants with genetics/genomics/genome engineering expertise.
careers.springernature.com/j…