Neuroscientist interested in Sleep, Pain and Consciousness. #UmichAnes. 🇺🇾🇺🇸. BJJ enthusiast. Opinions/likes = my own.
Ann Arbor, MI
Joined February 2019
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Ever wondered whether #sleep and wake-related neurons influence general anesthesia? Read what we learned in our new study:
Activation of Preoptic GABAergic or Glutamatergic Neurons Modulates Sleep-Wake Architecture, but Not Anesthetic State Transitions cell.com/current-biology/ful…
It's published!
In short, we found a preoptic mechanism that powerfully suppresses REM sleep (but there's much more):
academic.oup.com/sleep/artic…
#sleep #sleepresearch #REMsleep #sleephomeostasis
Brainstem pathology in human narcolepsy: Neurodegeneration in the locus coeruleus in narcoleptic humans, but not in genetically narcoleptic mice or dogs biorxiv.org/content/10.1101/…
Giancarlo Vanini retweeted
(Plz repost)
I’ve been receiving some good news lately and will be hiring at all levels to expand the lab. Please get in contact if you are interested in reinforcement learning, neural plasticity, circuit dynamics, and/or hearing rehabilitation.
pierre.apostolides @ umich .edu
Whole-night gentle rocking improves sleep in poor sleepers with insomnia complaints. biorxiv.org/content/10.1101/…
Maybe I'll start "My week's top articles"; if I do, this is this week's winner on my list! 👇
Giancarlo Vanini retweeted
New article by the Michigan Psychedelic Center published in Translational Psychiatry- psilocybin induces acute reorganization of functional cortical networks in rodents. nature.com/articles/s41398-0…
Giancarlo Vanini retweeted
We are depositing the following mice to @MMRRC
Adgrf5-EGFP-CT-IRES-CRE
GPR123- EGFP-CT-IRES-CRE
GPR124- EGFP-CT-IRES-CRE
GPR125- EGFP-CT-IRES-CRE
Gpr133-EGFP-CT-IRES-CRE
GPR156-IRES-Cre
GPR156-mGL-IRES-Cre
GPR75-IRES-Cre
Bai1 mGL-CT-IRES-Cre
GPRC5A- EGFP-CT-IRES-ERT2-CRE
1/2
Giancarlo Vanini retweeted
these recent breakthroughs, which give hope to parents, were only possible via nationally funded basic research.
cell.com/cell/fulltext/S0092… <- ID’d otof as ca2+ sensor (France)
pnas.org/doi/10.1073/pnas.17… <-central ca2+ sensors will not replace otof function, must use otof (USA)
Gene therapy restores hearing (!!)
This is the goal. Beautiful mechanistic therapies with effect sizes so big that they can be seen in the very first dozen patients dosed.
Congrats to the one and only Steve Holtzman and the Decibel team for establishing this program, and to Regeneron for carrying it forward.
Just heard from a very good friend and expert neuroanatomist that the preoptic area is not hypothalamus.
Nonsense! Must be the water on the west coast. 😂
Giancarlo Vanini retweeted
Since we're talking about funding of absurd research by NIH and other federal agencies, the funded scientists:
- watching flies fuck
- giving rats massages
- spending years digging into why jellyfish glow
- tracking penguin poop from space
- using horseshoe crab blood
Giancarlo Vanini retweeted
Happy end of Daylight Saving Time. For health, safety, and economics let’s keep Permanent Standard Time. @SRBR_Outreach @SaveStandard @ResearchSleep
NEW Preprint!
We show that preoptic glutamatergic neurons control REM sleep generation and their activation suppresses REM sleep rebound after sleep deprivation.
Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons biorxiv.org/content/10.1101/…
Giancarlo Vanini retweeted
Want to join a vibrant neuroscience community with lots of cool people doing high quality work? Please apply.
MNI is actively recruiting for 𝙨𝙚𝙫𝙚𝙧𝙖𝙡 𝗳𝗮𝗰𝘂𝗹𝘁𝘆 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀, seeking the best and brightest in #neuroscience to fill these roles. Please 💛 and r/t this to help us reach some great candidates! 〽️🧠 More info: michmed.org/GqG8z
Giancarlo Vanini retweeted
MNI is actively recruiting for 𝙨𝙚𝙫𝙚𝙧𝙖𝙡 𝗳𝗮𝗰𝘂𝗹𝘁𝘆 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀, seeking the best and brightest in #neuroscience to fill these roles. Please 💛 and r/t this to help us reach some great candidates! 〽️🧠 More info: michmed.org/GqG8z
Giancarlo Vanini retweeted
Congrats @sachinkheterpal for the 2024 @ASALifeline Excellence in Research award. Well deserved. @UMichAnesthesia @_Anesthesiology pubs.asahq.org/anesthesiolog…