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Discovery of Bacterial Toxin Could Lead to New Antibiotics

Scientists have discovered a new toxin secreted by Pseudomonas aeruginosa that kills cells via the modification of RNA. P. aeruginosa colonizes diverse environments, including humans, because it can...

Fat to Brain Communications Clarified

Scientists at Scripps Research Institute have discovered sensory neurons that relay messages from fat cells to the brain, establishing that the brain actively surveys body fat, rather than just...

Neuron Loss in Huntington’s Disease Linked to Deficiency in Glial Transcription Factor

Scientists have identified a causal link between the expression of a transcription factor in glial cells and the retention of myelin in two independent animal models of Huntington’s disease (HD). The...

Rapamycin’s Anti-Aging Promise Gains Further Support

Brief exposure to rapamycin in early adulthood has the same anti-aging effects as lifelong treatment, scientists claim. Life-long or long-term rapamycin dosing can have negative side effects, earlier...

Mucus Reveals New Evolutionary Mechanism

Scientists from the University at Buffalo compared genomic differences in a class of sugary proteins found in mucus called mucins and discovered 15 instances in 49 species where mucins evolved by...

Universal Flu Vaccine Candidate Exploits Conserved Domains

Scientists at Georgia State University have designed a universal flu vaccine that protects against both influenza A and B virus types and successfully tested its efficacy in young and aged mouse...

Gene Activity Enlists Navigation Cells to Lend a Sense of Space

A study on mice uncovers molecular mechanisms that underlie spatial mapping in the brain.

Organoid Culture Optimized to Match Human Small Intestines

A signaling mechanism that includes the helical cytokine IL-22 (interleukin-22) and the kinase mTOR (mammalian target of rapamycin), is required for human progenitor cells to differentiate into...

Pancreatic Development Disrupted by Mutations in the Dark Genome

Mutations in the enhancer element EnhP responsible for malformations in the pancreas and diabetes in newborns, indicate disruptions in nonprotein coding DNA elements can cause inherited diseases. The...

Environment Friendly CRISPR Technology Could Check Crop Pests

A CRISPR-based method can generate sterile but competitive males of a pest species that poses a threat to food crops in western countries.

Mining Host Immune Memory to Track Errant Gut Bacteria

A host organism’s immune responses to gut microbes can be mined by sequencing immunoglobulin G to identify gut bacteria that have translocated across the gut to trigger inflammatory diseases.

Sequencing Living Cells Made Possible Through Live-Seq

A new RNA sequencing technology, Live-seq, enables the sequencing of transcriptomes in individual cells without killing them.

Fear and Unpleasant Memories Depend on Integrated Parallel Pathways

Neurons expressing calcitonin gene-related peptide in the thalamus and the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negatively tagged signals to the...

Multiple Sclerosis Drug Normalizes Hypermetabolic Red Blood Cells

Interferon-beta drugs inhibit albumin binding to the red blood cells, thereby reducing its ability to deliver ligands such as C-peptide and zinc ions to the cell and normalizing the basal hypermeta...