GPCR lover. Pharmacology / Biochemistry / Neuroscience. PI @SBRC. Assistant Professor @UManitoba. Alumnus of @WesternU @uOttawa @ScrippsResearch @UF. 🇨🇦
Winnipeg, Manitoba
Joined May 2019
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Very excited to share our most recent work describing ELFN2’s function in the brain as a novel transsynaptic modulator of group III mGluRs essential for tempering excitatory neurotransmission and neuropsychiatric behaviors in mice! nature.com/articles/s41380-0…
PhD position available (PIs: Dunn & Fernyhough) to study mechanisms of M1 receptor biased signalling to promote neurite outgrowth.
jobs.sciencecareers.org/job/…
Henry A. Dunn retweeted
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
nature.com/articles/s41467-0…
Henry A. Dunn retweeted
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao.
nature.com/articles/s41467-0…
Henry A. Dunn retweeted
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward.
pnas.org/doi/epub/10.1073/pn…
Henry A. Dunn retweeted
The 2024 MNN Research Symposium was a resounding success with ~180 Manitoban neuroscientists gathered for the latest in cutting-edge 🧠 research. Special thanks to our amazing sponsors, and @BrainCanada @VivianePoupon for joining us to discuss the future of Canadian neuroscience.
Henry A. Dunn retweeted
First day back to work from maternity leave and starting a new job as a Research Associate @um_pharmacology. Lots of feelings but mostly excited to do science again! 🧠🥼🧬🔬#WomenInScience – at Winnipeg, Manitoba
Henry A. Dunn retweeted
Congratulations to everyone who participated in the @umanitoba Undergraduate Research Showcase, especially the winners from our department:
✅ 1st Place Poster: Kaden Baskerville (@GPCRHenry Lab)
✅ 3rd Place Poster: Louis Dela Pena (@JoelDPearson Group)
news.umanitoba.ca/2023-under…
🎉 Congratulations to all the winners and participants of the Undergraduate Research Showcase! 🎉 @umanitoba
Very disappointed to be cancelling my trip to the #2023GPCRRetreat tomorrow due to COVID.
Was very much looking forward seeing everyone and returning to Montebello - a venue the retreat hadn’t been to in over 10 years and was one of my all time favourites. Enjoy, everyone! – at Winnipeg, Manitoba
An incredible study and resource with many important findings: including reclassification of group I mGluRs and some DREADDs, to name a few! Many congratulations to Kirill, Ikuo, and team. – at Winnipeg, Manitoba
Our systematic investigation of G protein coupling profiles of 100+ #GPCRs driven by the one and only Ikuo Masuho is out after ~10 years of work. We see many interesting patterns with the help of AI. Check it out- there is a useful reference table.
doi.org/10.1016/j.celrep.202…
Henry A. Dunn retweeted
Congrats to UM’s Dr. Henry Dunn @GPCRHenry on being named a Future Leader in Canadian Brain Research. His research explores new treatments for epilepsy, ADHD and autism. Read more about his neurobiology work and the $100k Brain Canada grant: news.umanitoba.ca/um-assista… #UManitoba #UMResearch @BrainCanada
Very pleased to receive this honour! – at Winnipeg, Manitoba
Congratulations to the new cohort of Future Leaders in Canadian Brain Research! In its fourth year, @BrainCanada’s flagship program is providing funding to its largest-ever cohort of researchers, with 28 recipients! For more information ➡️braincanada.ca/announcements…
Henry A. Dunn retweeted
The recent thread about diplomas in offices got me to thinking about two different offices I’ve visited. One was filled with diplomas and awards—no free space was devoid of an award or diploma. The other was filled with rock music memorabilia…I enjoyed that one immensely.
Come join our Department!
Feel free to reach out to me with any questions!
🚨 Calling all Cardiovascular Sciences experts! We're hiring a tenure-track/tenured Assistant/Associate Professor @um_pharmacology, @umanitoba! Develop your independent research program and contribute to our world-class research initiatives 🚨 #AcademicJob viprecprod.ad.umanitoba.ca/d…
Can’t wait to see this in final form! – at Winnipeg, Manitoba
Such a wonderful start of the day! Hang on as we are about to tell a story about #GPCR for neurotransmitter glycine. Happy Friday everybody! Work of the incredible scientist @ThibautLaboute.
First day in the lab as a PI @SBRC and Assistant Professor @UManitoba where we’ll study GPCR pharmacology & neuropsychiatric disease! Excited to begin filling this lab with colleagues to share in GPCR enthusiasm - passed down to me from my mentors @FergusonottawaS and @KLabGPCR!
A compelling trafficking study demonstrating mGluR7 mobility and subsynaptic localization are predominantly regulated by it’s extracellular domain - suggestive of the integral role of trans-synaptic interactors (like ELFNs) in group III mGluR biology. Glad to see this published!
Finally it is out! Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. molbiolcell.org/doi/10.1091/…
I've just registered for the GPCR Retreat and I couldn't be more thrilled! I haven't missed one since my first attendance in 2008 and it feels extra personalized this year with my mentors @FergusonottawaS and @KLabGPCR as Keynotes. Looking forward to seeing everyone in person!
It’s been incredible watching this develop! Congratulations to all involved, especially @Dipak_P_tsri and @KLabGPCR!
Can a #GPCR structure still surprise you? Happy to present #CryoEM structure of an orphan receptor GPR158.
science.org/doi/10.1126/scie…
Couples to RGS instead of G proteins.
Features an extracellular Cache domain for ligand binding
Forms a unique tight dimer stapled by phospholipids
Henry A. Dunn retweeted
G protein Go couples to virtually all #GPCRs. It is one of the most abundant proteins in the brain and mutations in it cause #GNAO1 disorder. Here we describe how it regulates neuromodulatory signaling in the striatum. @gnao1research
cell.com/cell-reports/fullte…
