Prof Michael Gantier's lab @Hudson_Research studies the immunology of nucleic acids (such as mRNA therapeutics)
Australia
Joined May 2021
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Into nucleic acid immunity? 🌏 Join #NAIS2026 in Nara, Japan!
📅 Sept 16–18, 2026
🧬 Abstract deadline (extended): June 30
📝 Register by: July 31
Explore the latest in nucleic acid immunity & connect with global experts.
🔗 ifrec.osaka-u.ac.jp/nais26/i…
Ever wondered what happens to oligonucleotide therapeutics once they start to break down? In our new bioRxiv preprint, we provide a molecular dissection of how chemically modified 3‑base oligonucleotide fragments engage TLR7 and TLR8. Check it out! doi.org/10.64898/2026.04.29.…
Gantier Lab retweeted
Researchers led by Drs. Michael Gantier (@GantierLab), Toshiyuki Shimizu, and Ben Corry (@CorryLab) show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation.
📖: go.nature.com/4azVWjp
🔊: bit.ly/40muGA2
Gantier Lab retweeted
Recognition of RNA fragments by TLR7 and TLR8 helps to initiate the innate immune response.
This work redefines TLR7 and TLR8 sensing by introducing 2′-OMe guanosine as a natural immune checkpoint for their activation. @NatImmunol
🔗 go.nature.com/4azVWjp
We don't know yet. However it is conceivable that receptors such as TLR7/8 needed a built-in off-switch in their LRRs, and that it would have then evolved as a sensing mechanism when nucleic acids accumulate.
Gantier Lab retweeted
How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with
@GantierLab
shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ nature.com/articles/s41590-0…
We propose it is the accumulation of agonistic fragments (short RNAs and nucleosides which work cooperatively) which outcompetes the basal natural antagonism.
I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > nature.com/articles/s41590-0…
Gantier Lab retweeted
IsomiR stoichiometry changes as disease biomarkers. dlvr.it/TLDYyK #MTNA
Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this!
cell.com/molecular-therapy-f…
For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at rnavic.com/
Please mark your calendars for the next RNAVIc symposium. It will be July 22nd at WEHI Davis Auditorium starting at 2pm. rnavic.com/
Gantier Lab retweeted
We are thrilled to announce the official launch of the #RNAte Platform at @Hudson_Research, delivering huge advances in the development of #mRNA-based therapies. 🥳💪🏽
Read more about this revolutionary platform: bit.ly/3SEEl23
@VicGovAu @VicGov_DJSIR
Gantier Lab retweeted
We recently welcomed Deputy Premier & Minister for Medical Research, The Hon @BenCarrollMP to Hudson Institute! 🙌
Minister Carroll went behind the scenes with some of our researchers, including our CEO & Director Prof Elizabeth Hartland, to learn more about our research.🔬
ALT Deputy Premier & Minister for Medical Research, The Hon Ben Carroll and Hudson Institute CEO & Director Professor Elizabeth Hartland
ALT Deputy Premier & Minister for Medical Research, The Hon Ben Carroll speaks with researchers at Hudson Institute
Gantier Lab retweeted
Thrilled to be joining longtime friends and colleagues @CiiiD_Hudson including those I could find on twitter @ProfHartland @FerreroMicro @Tate_Lab @GantierLab @pjhpauljh @Forster_Lab @PhilBardin
Gantier Lab retweeted
Exciting data to build our research program on thromboinflammation! So proud of this first research paper! Thanks to the many students and collaborators who contribute to this story! life-science-alliance.org/co…
