🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, two additions to our collection of Reviews on Cancer Metabolism, and more... Click here to learn more: ➡️ genesdev.cshlp.org/content/4…

🆕 ADVANCE ONLINE 🆕 REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics By Smith et al. and Yu (Sunny) Liu ➡️ ow.ly/YJS150ZW4Gj @YuLiu_Sunny @CeiFccc @FoxChaseCancer @FCCCAcademics #cancer #epigenetics #chromatin

ON THE COVER: MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis Artwork by by Jianhua Zhao Learn more in these complementary studies by Anindya Bagchi’s group: ➡️ ow.ly/35Eb50ZZsHm

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters By Gonzalez et al. and Pablo Navarro ➡️ ow.ly/LWC250ZXNv7 @pablonavarroLAB @institutpasteur #transcription #transcriptionfactor #mitosis #MYC

🎙 G&D Voices: Author Lluis Morey 🎙 G&D continues to inspire scientists and publish influential research. G&D author, Lluis Morey, tells us why he chooses to publish in G&D.

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency By Fan et al. and Marikki Laiho ➡️ ow.ly/mp8650ZW4ZN @JohnsHopkins #cancer #ribosome #translation #mTOR

🌟 G&D SPOTLIGHT 🌟 G&D is pleased to present a collection of recent articles on gene regulation, RNA processing, and chromatin. Learn more about the molecular mechanisms shaping gene expression and cell function: ➡️ genesdev.cshlp.org/site/misc…

🆕 ADVANCE ONLINE 🆕 REVIEW: Regulatory circuits that build and sustain noninfectious granulomas By Ridky et al. and Thomas Leung ➡️ ow.ly/BY5c50ZW4IH @realthomasleung @Penn #cancer #inflammation #granuloma

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes By Ma et al. and ens Lykke-Andersen ➡️ ow.ly/NZ6A50ZW4wv @UCSanDiego #RNA #RNAdecay #RNAsplicing

RESEARCH PAPER: Nuclear type I myosins actively support nucleolar and nuclear structure and function By Peng et al. and Brian Freeman ➡️ genesdev.cshlp.org/content/4… #genome #nucleus #myosin

RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities By Jayachandran et al. and Petr Cejka ➡️ genesdev.cshlp.org/content/4… @BellinzonaIrb #DNA #DNArepair #DNAsynthesis #helicase

🎙️ G&D Voices: Author Anindya Bagchi🎙️ Two complementary studies, one complete story. G&D Author, Anindya Bagchi, tells us about why G&D was the right home for their work. Learn more here: ➡️ genesdev.cshlp.org

RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors By Paithane et al. and Anindya Bagchi ➡️ genesdev.cshlp.org/content/4… Also read: ➡️ genesdev.cshlp.org/content/4… #cancer #MYC #KRAS #lncRNA

RESEARCH PAPER: Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis By Tiwari et al. and Anindya Bagchi ➡️ genesdev.cshlp.org/content/4… Also read: ➡️ genesdev.cshlp.org/content/4… #cancer #MYC #KRAS #lncRNA

CANCER METABOLISM REVIEW: Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression By Carolina Dehesa Caballero and Almut Schulze ➡️ genesdev.cshlp.org/content/4… @almut_schulze @MetaboholicsLab @HeidelbergU @DKFZ #cancer #metabolism

OUTLOOK: Cycling off: a novel mechanism for differential cell cycle-dependent histone gene expression By Lauren Hodkinson and Erica Larschan ➡️ genesdev.cshlp.org/content/4… Also read: ➡️ genesdev.cshlp.org/content/4… @EricaLarschan @laureninthelab @BrownUniversity #histone #mRNA

RESEARCH PAPER: Temporal gating dictates stress-induced transcript export from the nucleus By Helton et al. and Stephanie Moon ➡️ genesdev.cshlp.org/content/4… @smslmoon @umichrna @umichmedicine #mRNA #stress #RNAexport

📽️ G&D Tapes 📽️ G&D Author, Kei Ishiguro, tells us about how the MEIOSIN-STRA8 interaction reinforces meiotic transcription and facilitates meiotic progression. Read the full story: ➡️ genesdev.cshlp.org/content/4… @IshiguroL #celldivision #transcription #vertebratedevelopment

RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs By Dix, McQuarrie, Bräuer et al. and Matthias Soller ➡️ genesdev.cshlp.org/content/4… #RNAprocessing #neuron #Drosophila

📽️ G&D Tapes 📽️ G&D Authors in the Higuchi-Sanabria lab tell us about how the neuronal expression of the chromatin reader BET1 influences aging. Read the full story: ➡️ genesdev.cshlp.org/content/4… @NaibedyaDutta @UniversityofSo5 @USCLeonardDavis #neuron #chromatin #aging

RESEARCH PAPER: MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates By Shimada et al. and Kei-ichiro Ishiguro ➡️ genesdev.cshlp.org/content/4… @IshiguroL #celldivision #transcription #vertebratedevelopment