Upcoming Webinar: A case study in Xenopus using HCR™ Pro RNA-CISH and HCR™ Gold RNA-FISH to maximize sensitivity and multiplex capabilities Different experimental questions can call for different readouts: high-sensitivity chromogenic detection for low-abundance targets, and multiplexed fluorescent imaging for quantifying expression across multiple targets. Join Professor Douglas Houston from the @uiowa to see how HCR™ Pro RNA-CISH can support ultra-sensitive chromogenic detection and brightfield imaging in whole-mount embryos, and how HCR™ Gold RNA-FISH can complement that workflow for high-resolution, quantitative analysis. 🗓️ Thursday, October 29 🕗 8:00 AM PT / 10:00 AM CT Register today: my.demio.com/ref/XCVLmHOnaJG…

We’re heading to Woods Hole, MA for the 12th Aquatic Models of Human Disease Conference at @MBLScience! Join Aneesh Acharya and Megan Le on Monday, October 19, for our scientific session exploring how the HCR™ platform can support research across aquatic model organisms and sample types. Bring your questions, share your research and use cases, and stop by our table to connect with the team. We look forward to seeing you there!

Behind every breast cancer awareness campaign are researchers, pathologists, and clinicians helping us better understand the disease. This month, we’re taking a moment to recognize the science, care, and dedication behind that progress. We’re honored to support the research community working toward deeper insight and better outcomes.

How can researchers maximize sensitivity when detecting low-abundance RNA targets in whole-mount embryos? In our upcoming webinar, Prof. Douglas Houston from the University of Iowa will share how manual HCR™ Pro RNA-CISH can support brightfield screening of low-abundance RNA targets across multiple Xenopus embryos. He’ll also discuss how HCR™ Gold RNA-FISH can help move promising observations into high-resolution, multiplexed fluorescent analysis, plus approaches for combining RNA detection with immunostaining. 🗓️ Thursday, October 29 🕗 8:00 AM PT / 10:00 AM CT Register here: my.demio.com/ref/XCVLmHOnaJG…

Introducing HCR™ HiFi Secondaries! We’re extending our proprietary HiFi background suppression technology to HCR™ HiFi Secondaries, giving researchers two powerful ways to multiplex protein labeling: • HCR™ HiFi Encoders enable straightforward multiplexing with same-species primaries • HCR™ HiFi Secondaries enable best-in-class amplification for the broadest range of primaries, including those raised in chicken, rat, goat, and other host species Both can be combined in the same IF assay and are natively compatible with HCR™ Gold RNA-FISH for RNA + protein co-detection, allowing you to select the best approach for your research. Shop HCR™ Gold 2°IF today: store.molecularinstruments.c…

Up next: SoCal SOT! The MI team is headed to @ionispharma tomorrow for the Southern California @SOToxicology Fall Meeting! At the event, we’ll focus on an important step that comes before AI-driven image analysis: generating high-quality, interpretable images. Our presentation will feature HCR™ imaging approaches for short RNA targets, including siRNAs and oligonucleotide payloads in AOCs, alongside multiplex immunofluorescence with HCR™ HiFi Encoders. If you’re attending, stop by and say hello. We’d love to connect!

Join us for an upcoming webinar with Professor Douglas Houston from the @uiowa! Prof. Houston will share a Xenopus case study exploring how HCR™ Pro RNA-CISH and HCR™ Gold RNA-FISH can be used together to balance extreme-sensitivity RNA detection with multiplexed fluorescent analysis. The webinar will cover ultra-sensitive chromogenic detection of low-abundance RNA targets in whole-mount embryos, along with approaches for RNA and protein co-detection. 🗓️ Thursday, October 29 🕗 8:00 AM PT / 10:00 AM CT Register here: my.demio.com/ref/XCVLmHOnaJG…

More fluorophore options, more ways to build your HCR™ Gold assay. HCR™ Gold Amplifiers are now available with 488, 546, 594, and 647 labels across every X system, giving you more flexibility when designing panels around your targets and imaging channels. Ready to explore the new options? Shop the expanded amplifier selection today. 🛒 store.molecularinstruments.c…

Yesterday, we hosted a webinar on “Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution.” A special thank-you to our wonderful speakers, @jxqjim and @LunWangm from @Stanford, for sharing how TRU-FACT integrates #HCRtechnology with functional imaging and connectivity data to link cellular activity, molecular identity, and projection targets. We enjoyed this installment of HCR™ webinars and look forward to sharing more soon!

We’re heading to the @NS4Histotech Convention this weekend! Come say hello at Booth #620 to connect with our team and join us for our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” where we’ll highlight how #HCRtechnology can be adapted for lateral flow detection. 🗓️ Sept. 29 🕤 9:15–10:15 AM

We're excited to introduce Slide Wash Chambers for manual slide-based workflows! Orders that include HCR™ Wash Buffers for tissue sections or cells on a slide will now receive two complimentary Slide Wash Chambers. Each chamber provides a lower-volume alternative to traditional Coplin jar setups, helping reduce wash buffer use during manual assays. Add HCR™ Wash Buffers to your next order to receive yours: molecularinstruments.com/sho…

What a fantastic time at the German Fish Meeting! It’s always exciting to see #HCRtechnology used in such a wide range of model systems. This week, it was especially fun to hear about so many fish models, including zebrafish, cavefish, and more. Thank you to everyone who stopped by to share how you’re using HCR™ workflows in your research. We loved hearing about the variety of applications across the fish model community. Next up for the MI team: @NS4Histotech Convention!

San Antonio, we’ll see you soon! The MI team will be at the National Society for Histotechnology Convention. Stop by Booth #620 to talk about HCR™ workflows, RNA and protein imaging, and how our team can support your research goals. Don’t miss our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” for a practical look at adapting #HCRimaging for lateral flow detection. 🗓️ Tuesday, September 29 🕤 9:15–10:15 AM See you there!

More fluorophore flexibility for HCR™ Gold is here! HCR™ Gold Amplifiers with 488, 546, 594, and 647 labels are now available for every X system, giving you more flexibility to configure assays around your specific target panel and imaging setup. All new catalog amplifiers are available to order on our webstore. Order here: store.molecularinstruments.c…

What can you learn when cellular activity, molecular identity, and projection targets are connected in the same cells? Join @LunWangm and @jxqjim from @Stanford on Wednesday (Sept 23) at 10:00 am PT for a closer look at TRU-FACT, an experimental and computational pipeline for registering individual cells across in vivo imaging and molecular profiling datasets. Register here: my.demio.com/ref/qB2R1mep0on…

More automation options for HCR™ Gold IF! We’re thrilled to share that HCR™ Gold IF is now available on the Biocare Medical ONCORE Pro X staining platform. Powered by the HCR™ HiFi Encoder, HCR™ Gold IF helps researchers build multiplex immunofluorescence assays with off-the-shelf primary antibodies, including same-species combinations, without custom conjugation, stripping, or fixed antibody panels. The workflow also supports species-on-species staining, including mouse-on-mouse and human-on-human assays. Read the full announcement: businesswire.com/news/home/2… Interested in getting started? Contact us at [email protected].

Don’t miss our upcoming webinar featuring @LunWangm and @jxqjim from @Stanford! Discover how TRU-FACT registers individual cells across in vivo imaging and molecular profiling datasets, connecting cellular activity, molecular identity, and projection targets at cellular resolution. 🗓️ Wednesday, September 23 🕤 10:00 AM PT Learn how #HCRtechnology helps enable the molecular profiling behind these multimodal alignments. Register here: my.demio.com/ref/qB2R1mep0on…

Next stop: the 1st German Fish Meeting! From zebrafish to cavefish, #HCRtechnology enables sensitive, multiplexed RNA and protein imaging across diverse fish models, helping researchers visualize gene expression with high-resolution across samples and developmental stages. Join us on Wednesday (Sept. 16) for our workshop featuring an overview of the platform, deeper dives into HCR™ Gold RNA-FISH and HCR™ Gold IF, and office hours for live experiment planning. Session 1: 9:00 AM Session 2: 10:45 AM 📍Center for Organismal Studies, University of Heidelberg 🗓️ September 16 - 18, 2026

Spotlighted by the @InfoIzfs: Dr. Elliot Perens (@UCSanDiego, @radychildrens) used HCR™ imaging to capture the posterior lateral mesoderm in zebrafish. 🟠 gata1a 🟢 etv2 🔵 hand2 🟣 hnf1ba Check out the IZFS feature here: izfs.org/news/new-izfs-websi…

Build HCR™ Gold IF Around More Primary Antibodies More antibody panels can now be configured for HCR™ Gold IF! With Rabbit IgG and Mouse IgG1 Encoders now available across X1-X10, plus new Mouse IgG2a and Human IgG options, you now have more flexibility to design sensitive, multiplexed protein imaging experiments around the antibodies and channels that best fit your research workflow. Whether you’re building a same-species panel or expanding into higher-plex protein imaging, these additions make it easier to design around the antibodies and channels your experiment requires. Configure your manual HCR™ Gold IF assay here: lnkd.in/gyxQvTPA Interested in automated HCR™ Gold IF workflows? Contact your MI representative or email [email protected], and our team can help you get started.