Harrison Sudholz (@HSudholz) header
Harrison Sudholz (@HSudholz) profile picture

Harrison Sudholz

@HSudholz

Postdoc - University of California, Berkeley

 Berkeley, CA
Joined July 2012
  • Tweets51
  • Following433
  • Followers119
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Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)Photo by Harrison Sudholz (@HSudholz)
Harrison Sudholz retweeted
Cell Reports (@CellReports) profile picture
Cell Reports@CellReports4 Aug 2025
Core fucosylation of IL-2RB is required for natural killer cell homeostasis dlvr.it/TMJ4p5

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Sudholz et al. identified the core fucosyltransferase, FUT8, as an essential component for maintaining NK cell homeostasis, namely through the post-translational modification of the IL-15 receptor....

cell.com
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It's great to have this work from my PhD out now in Cell Reports! This work showed the importance of core fucosylation on NK cells. When core fucose is lost, NK cells will experience reduced CD122 expression, impaired cytotoxicity and severe lymphopenia.
Waggoner Lab (@LabWaggoner) profile pictureWaggoner Lab@LabWaggoner2 Aug 2025
Core fucosylation of IL-2RB is required for NK cell homeostasis @CellReports @Dr_Nick_Bikes @HSudholz cell.com/cell-reports/fullte…
Image from Waggoner Lab (@LabWaggoner)
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Harrison Sudholz retweeted
Prof Paul Beavis (@paulbeavis4) profile picture
Prof Paul Beavis@paulbeavis42 Jul 2025
Delighted to share our new approach to enhance CAR T cell function in solid tumours published today @Nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s41586-0…
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Nature - A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer ‘armoured’ CAR T cells that secrete proinflammatory cytokines directly within a tumour...

nature.com
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This past week, I was lucky enough to attend the bioinformatics bootcamp in Orlando, Florida, organised by CRI. @CancerResearch As a wet lab scientist, I was expecting to struggle with the basics of coding.
Image from Harrison Sudholz (@HSudholz)
Image from Harrison Sudholz (@HSudholz)
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However, thanks to some expert tuition I have left with a wealth of knowledge on the workflows required to analyse and present bulk and single-cell RNAseq, spatial transcriptomics and even a custom workflow to automate the graphing of my own flow cytometry data!
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Thank you to all of the organisers and teaching associates for this opportunity. I am looking forward to following up with all of the CRI fellows at CICON conference later this year and see how we are all implementing computational biology into our day to day operations.
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🎉 CRI is proud to announce our Fall 2024 class of CRI Irvington Postdoctoral Fellows and Immuno-Informatics Fellows! Meet the exceptional researchers who are investigating novel therapeutic strategies to harness the immune system against cancer: bit.ly/4hSZlvB
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Tomorrow I'll be running the 2XU wellness run with members from my local run club. We'll be running along with many others to help raise critical funds for beyond blue and hopefully a few pb's 2xuwellness24.grassrootz.com…
Image from Harrison Sudholz (@HSudholz)
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Congrats @HSudholz on the PhD thesis defence. Was a ripping defence, reminded me of Brandon Starcevich in the Grand Final 🦁 – at Melbourne, Victoria
Image from Nicholas Huntington (@Dr_Nick_Bikes)
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Phd thesis submitted, what a journey. Thanks to @Dr_Nick_Bikes and @SebScheer for their supervision over the past few years. Hawthorn will be back next year.
Nicholas Huntington (@Dr_Nick_Bikes) profile pictureNicholas Huntington@Dr_Nick_Bikes13 Sep 2024
Another PhD thesis submitted from Huntington Lab @MonashBDI Congrats @HSudholz on a high quality 3 years of NK cell discoveries. C'arn the Hawks!!!
Image from Nicholas Huntington (@Dr_Nick_Bikes)
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Another PhD thesis submitted from Huntington Lab @MonashBDI Congrats @HSudholz on a high quality 3 years of NK cell discoveries. C'arn the Hawks!!! – at Melbourne, Victoria
Image from Nicholas Huntington (@Dr_Nick_Bikes)
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Harrison Sudholz retweeted
The Scientist (@TheScientistLLC) profile picture
The Scientist@TheScientistLLC9 Aug 2024
NK cells are an important anti-cancer defense, but what happens if they turn into a different cell type? A new study from @SebScheer @Dr_Nick_Bikes identified a gene without which NK cells turn into a weaker cell type, making them worse at fighting cancer. bit.ly/3SKxSCl
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Harrison Sudholz retweeted
Dr Becs (@ScientistBecs) profile picture
Dr Becs@ScientistBecs14 Jun 2024
Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵cell.com/immunity/fulltext/S…
Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...

cell.com
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Harrison Sudholz retweeted
Audax Bio (@audax_bio) profile picture
Audax Bio@audax_bio14 Jun 2024
New research from our CSO @Dr_Nick_Bikes lab at @MonashUni has just revealed a crucial epigenetic regulator of natural killer cells 👏 #nkcelltherapy #naturalkillercells #epigenetics #cancerresearch #immunooncology #MonashUni @CellReports cell.com/cell-reports/fullte…
DOT1L maintains NK cell phenotype and function for optimal tumor control

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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Harrison Sudholz retweeted
Cell Reports (@CellReports) profile picture
Cell Reports@CellReports13 Jun 2024
DOT1L maintains NK cell phenotype and function for optimal tumor control dlvr.it/T8D8Jb
DOT1L maintains NK cell phenotype and function for optimal tumor control

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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Harrison Sudholz retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggoner12 Jun 2024
DOT1L supports MEF2C expression to allow optimal NK cell phenotype and function @SebastianScheer @Dr_Nick_Bikes @HSudholz @CellReports @The_DE_Lab @schuster cell.com/cell-reports/fullte…
DOT1L maintains NK cell phenotype and function for optimal tumor control

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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Thrilled to announce a new publication from the Huntington Lab, featuring key works from my PhD project. This was a collaborative effort with many thanks going to @SebScheer now at @LIH_Luxembourg, @Dr_Nick_Bikes and co-authors from the @MonashBDI. cell.com/cell-reports/fullte…
DOT1L maintains NK cell phenotype and function for optimal tumor control

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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We having identified a key role for histone methyltransferase, DOT1L, in regulating the epigenetic landscape of NK cells. Loss of DOT1L in NK cells skews their conversion into an ILC1-like subset, limiting their capacity to control solid tumours and expand in viral infections.
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This greatly deepens our understanding of how epigenetics influences NK cell fate and immune responses, particularly in cancer patients treated with inhibitors against DOT1L.
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New publication from our lab 📣 cell.com/cell-reports/fullte… We demonstrate that Histone methyltransferase, DOT1L, limits NK cell conversion to ILC1s, a subset that can be observed in tumors in response to TGF-β and is correlated with poor tumor control @HSudholz @SebScheer – at Melbourne, Victoria
DOT1L maintains NK cell phenotype and function for optimal tumor control

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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