Science, technology, singularity, transhumanism, crypto, 3D reconstruction and food.
Joined March 2008
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Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
thanks to AI, drug discovery will soon accelerate 1000's x (short term)
previous record - IsoDDE: 75.58%
New AI model surpasses AlphaFold 3 in critical drug discovery tasks
Geodesic Intelligence has unveiled NovaAtom Lite, a powerful AI model that predicts the 3D structures of proteins, DNA, RNA, and their molecular interactions with atomic level detail.
In benchmarks, it achieved 79.1% success in antibody antigen prediction, compared with AlphaFold 3's 47.9%, and 77.1% in proteinβdrug molecule interactions, compared with 64.9%.
Acceleration is everywhere, but the most important acceleration of all is happening in healthcare, medicine AI.
π€ Paid partnership
Introducing NovaAtom-Lite, an all-atom structure prediction model for drug discovery.
It predicts the structures of proteins, nucleic acids, and the molecules they bind, including how they fit together.
NovaAtom-Lite outperforms both IsoDDE and AlphaFold 3 on FoldBench antibodyβantigen structure prediction (DockQ β₯ 0.23):
NovaAtom-Lite: 79.07% (n=172)
IsoDDE: 75.58%
AlphaFold 3: 47.90% (n=167)
Our evaluation uses 5 seeds Γ 5 samples, with the top-1 prediction selected by the model's own ranking score.
Better structure prediction. A stronger starting point for your next experiment.
Live today via Geodesic API and NovaDDE.
π API: platform.geodesiclab.com/
π NovaDDE: agent.geodesiclab.com
π Model Card: geodesiclab.com/news/introduβ¦
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Introducing GR00T 2: our most advanced, open System One model for robotics. It runs entirely on your robotβs onboard compute, fully untethered, and you own every weight of it. GR00T 2 features:
1. Long-horizon tasks: dexterous manipulation and whole-body control chained over 20+ steps and 5+ minutes, such as performing chemistry lab experiments or assembling model airplanes end to end.
2. X-Adapt: adapting from easy data sources (human wearables and simulation) and deploying zero-shot to diverse real robots.
3. Unified Cognition: native integrations with frontier agents for advanced physical reasoning, robust error recovery, and safety monitoring.
It's an open-source buffet! We are releasing not only the model weights and X-Adapt recipes (coming December), but also our agentic framework, simulation engine, annotation engine, hardware design, and even training data (100K hours, that's ~11 yrs of experience), all available today!
Everything that moves will be autonomous. Anyone can become a roboticist.
Lock in, build with us!
Deep dive in thread:
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Gemini 4 Carbon from @Google on ARC-AGI (Verified):
- ARC-AGI-3: 99.1%, $4.6K (provider adapter), 65.1%, $7.2K (standard harness)
- ARC-AGI-2: 94.2%, $0.38/task
- ARC-AGI-1: 98.5%, $0.16/task
Carbon beat its predecessor Argon by 18% points on ARC-AGI-3 in the standard harness.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
the point of abundance is getting to enjoy some of it
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Okay, Seedream 5.5's consistency is crazy!!!
100 chained edits. Just +1 second on the watch each time. I didn't expect the gap to be this big.π
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Claude Fable 5.2 by @AnthropicAI in action across 17 generations on Arena, from detailed 3D worlds and playable games, to website UI, data visualizations, and interactive code-generated animations.
Big news: Claude Fable 5.2 (xHigh) by @AnthropicAI has landed #1 in the Code Arena: WebDev with 1832 pts. This update is up to 30% faster than Fable 5.1, and more cost efficient: $8/$40 per M tokens, down from $10/$50.
This real-world performance puts it ahead of:
- Claude Opus 5.5 (Max) at 1818
- Gemini 4 Carbon (High) at 1768
- GPT-6 Astra (Max) at 1767
Congrats to the @AnthropicAI team on this release! π
Stay tuned for Agent Arena scores.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Emergency Office Hours: Oppose the Ban on SuperintelligenceThis Thursday, November 12 at 5 PM,
AI Ethics Network is hosting an open discussion at The Collective Seattle on the proposed Ban Artificial Superintelligence Act (S.5493/H.R.10538).
We oppose this bill because it would:
Criminalize legitimate AI research with the threat of federal prison sentences for American scientists
Slow critical progress in safety, alignment, and beneficial AI systems
Drive talent and innovation overseas instead of keeping it in the U.S.
Replace thoughtful governance with a blunt ban that does not address real risks
Join us to discuss the bill, sign the petition, and plan next steps.
We are also looking for volunteers to help with outreach and action.
Details and RSVP: (You must RSVP for admittance) aiethicsnetwork.net/office-hβ¦
Collective
400 Dexter Avenue North, Seattle
Studio conference room
5 PM#AI #AIEthics #Superintelligence #AIPolicy
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
BREAKING: President Trump says he and the Department of Justice had a situation with "a leader of a major AI company" and were about to "send him to jail for doing something bad with AI."
"We said get ready to go to jail. See your wife and children because tomorrow morning you're going to jail," Trump said.
Trump says this person then "totally changed everything" and was not sent to jail.
Trump refuses to specify who this individual was.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
interesting little tidbit about Claudeβs reasoning effort notation! in the web app, this tag gets attached to the end of Claudeβs prompt on every turn:
<antml:reasoning_effort>8</antml:reasoning_effort>
low = 8, medium = 10, high = 30, extra = 80, max = βmaxβ
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
So Ai opposition was on the map in terms of issues causing folks to vote pro democrat and anti republican, but nowhere near the top. By 2028 it may be a more highly ranked issue ... meaning it would be worthwhile by that time to make more Dem voters understand how AI and AGi can be to ordinary peoples' benefit, an argument the republicans and big tech have been very poor at making
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
>Announce new model
>Celebrate victory without releasing it
>Vague post
>Get mogged by Competitors before you actually release your model
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
GOOGLE π₯: Users can now build AI apps powered by a wide range of Google Maps features, including 3D buildings, Street View, Weather, and others, with simple prompts.
Google AI Maps Studio π
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Fable 5.2 is HERE! π₯
I've burned over 100 billion tokens early testing Fable 5.2. It is BY FAR the best model I've ever used.
Here's my full review (including Gears of War clone):
> Fable 5.2 is the most autonomous model to date. Given a task with little direction, it makes assumptions that 99 times out of 100 are exactly what I would have done.
> It's a bug catching genius. I tasked it with going over all of my codebases and it found bugs that no other model would have found.
> It is the most capable model I've used with 3D generation. It is so good at controlling Unreal Engine and Blender. Check out my Gears of War clone attached.
> It's SUPER fast. I wasn't even using fast mode. It's less about how fast the tokens per second are, it's more about how it figures out direct paths to solutions. It doesn't get lost, it just knows exactly what it needs to do.
> And then there's Ultracode...which is ridiculously fast for massive tasks. I gave it massive codebase review tasks and it would finish in 10-20 minutes, finding every possible issue. I probably won't be using it as it'll burn my sub quota too quickly.
> Fable 5.2's completeness of work continued to surprise me. Clone Excel? Done...with full feature parity. Clone Gears of War? Done. Build a replica of Tokyo in Unreal? An entire simulated city is born. I rarely had to send follow up prompts to get it to complete something.
Now, will I use it over Opus 5.5? I will likely still prefer Opus because I can run Opus nearly 24/7 and rarely run out of quota. And for the hardest jobs, I'll switch to Fable 5.2 for planning.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Cells emit light (ultra weak photon emission, biological autoluminescence). The emission intensity is cell-type dependent (Mould et al., 2026, sciencedirect.com/science/arβ¦)
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Fable 5.2 shows substantially improved skills in controlling physical robots, even on tasks it has never explicitly been trained to do.
On RoboDojo, a benchmark with a simulated two-arm robot, it outperformed other models and most AI systems built to control robots.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Claude Fable 5.2 and Claude Mythos 5.2 are available now:
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Claude Fable 5.2 from @AnthropicAI on ARC-AGI (Verified):
- ARC-AGI-3: 97.7%, $18.6K (provider adapter harness), 81.2%, $21.9K (standard harness)
- ARC-AGI-2: 93.8%, $0.98/task
- ARC-AGI-1: 98.5%, $0.36/task
Fable 5.2 sets a new high score on ARC-AGI-3 in the standard harness.
Cris β€οΈπͺπΊπ¬πππ£πΊπΆβοΈβοΈ retweeted
Google says Gemini is helping make chip layouts IN HOURS rather than weeks.
AI helps design better chips, chips help train better AI, and that AI helps with even better chips.
from their new 8tx and 8i Max TPU blog:
βweβre even tapping into AI to ideate and build the next generation of AI infrastructureβ¦ using Gemini to deliver chip layouts in hours rather than weeks, weβre using TPU-powered AI services to rapidly accelerate next-generation TPU hardware development.β
Today, we're expanding our eighth-generation TPU portfolio with two new systems built specifically for the agentic era β bringing our total to four distinct eighth-generation TPU systems launched in a single year.
TPU 8i Max was built for massive context windows and the highest compute density per rack, and TPU 8tx is optimized for secure and confidential inference. While flexible across workloads, the four systems in our 8th gen TPU portfolio give developers and organizations a purpose-built accelerator for every stage of the agentic lifecycle.
@AminVahdat, SVP and Chief Technologist, AI and Infrastructure, explains why we're expanding our TPU portfolio and what everyone needs to know about TPU 8tx and 8i Max β¬οΈ
