The 'Dream Combo' in #EosinophilicAsthma: for those on #asthma biologics with persistent mucopurulent cough additional long term, low dose azithromycin is highly effective. Gabriel's findings from @OxfordBRC out today in thorax.bmj.com/content/early…

The new NICE/BTS/SIGN #Asthma guidelines are superb. A collaborative approach. A focus on using blood eos and FeNO at initial presentation and finally the long-overdue end to salbutamol. Read it and use it now nice.org.uk/guidance/NG245

1 million people switched from Twitter / X to BlueSky today. Come and follow us there, now on @hinkslab.bsky.social

Out today doi.org/10.1016/j.mucimm.202… our collaborator Adam Byrne shows airway macrophage glycolysis controls lung homeostasis and responses to aeroallergens. Exposure to house dust allergen drove glycolysis in alveolar macrophages; inhibiting this altered inflammation, via TLR2.

When exacerbations of severe #asthma occur despite being on type 2 biologics, what residual inflammation remains? In our latest paper from @OxfordBRC we show prednisolone caused broad down regulation of type 2 pathways in pts on mepolizumab. Full report: doi.org/10.1016/j.jaci.2024.…

Our new species-level study from @OxfordBRC shows severe #asthma microbiome is dominated by H. influenzae, M. catarrhalis and S. pneumoniae, driving neutrophilic inflammation, airway proteases and disrupting regulatory immune responses: doi.org/10.1111/all.16269

A 2 minute summary of our unexpected finding from @NDMOxford of tonic type 2 signalling in the airway mucosa in health. youtube.com/watch?v=inNYVjd-… funded by @asthmalunguk

Out today: an unexpected discovery from our Leicester/Oxford healthy volunteer bronchoscopy study. In health there is constitutive type 2 signalling within the airway mucosa, which is exquisitely sensitive to ICS. Read it now in doi.org/10.1111/all.16146

Want to find out more about azithromycin in acute and chronic respiratory disease? Join our ERS webinar on 14th May ersnet.org/events/azithromyc…

How can we help the 2/3 of people with a high FeNO who aren't using their inhalers adequately? As Fostair NEXThaler counter only triggers at an adequate inspiratory flow rate, the Leicester group have used dose counting with FeNO to detect non adherence. doi.org/10.1016/j.jaip.2024.…

The public are invited to a webinar hosted by @NIHRCRN_tvsm to ask questions of University of Oxford expert Prof Tim Hinks about the latest research into asthma 📅 Wednesday 17 May 🕛 7pm to 8pm. Read more and sign up: ow.ly/LFSb50NMxYP #asthma #asthmaresearch

Out today, NTHi is internalised by primary bronchial epithelial cells. It activates innate responses including CXCL8, IL-1β, IL-6 and TNF, independently of invasion, with more activation in nasal than bronchial cells, despite NTHi being a nasal commensal. doi.org/10.3389/fcimb.2023.1…

What are MAIT cells? How do they respond to the microbiome? How do they shape the microbiome? And how could we harness them for new treatments? Find out more in in Frontiers Immunol... doi.org/10.3389/fimmu.2023.1… on behalf of @NDMOxford @OxfordBRC with @CellsMait