Hongxiang Fu (@HongxiangFu) profile picture

Hongxiang Fu

@HongxiangFu

UPenn BE PhD student

Joined April 2023
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  • Following36
  • Followers21
Excited to share our latest work, “KnowYourCG: Facilitating base-level sparse methylome interpretation” in @ScienceAdvances! Our computational framework enables efficient functional enrichment for DNA methylation data from diverse assay platforms science.org/doi/10.1126/scia…
KnowYourCG: Facilitating base-level sparse methylome interpretation

KnowYourCG: Facilitating base-level sparse methylome interpretation

KnowYourCG is a scalable, CpG-based framework for DNA methylome interpretation for broad biological and technical links.

science.org
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Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team! nature.com/articles/s41586-0…
Spatial joint profiling of DNA methylome and transcriptome in tissues

Spatial joint profiling of DNA methylome and transcriptome in tissues

Nature - DNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription...

nature.com
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DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with @zhouwanding lab. Kudos to Chin Nien Lee @ChinNLee2021 and Hongxiang Fu! biorxiv.org/content/10.1101/…
Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues

Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues

The spatial resolution of omics dynamics is fundamental to understanding tissue biology. Spatial profiling of DNA methylation, which is a canonical epigenetic mark extensively implicated in transcr...

biorxiv.org
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Hongxiang Fu retweeted
Wanding Zhou (@zhouwanding) profile picture
Wanding Zhou@zhouwanding4 Jul 2025
New paper: we developed Methylation Screening Array (MSA)–a scalable tool to dissect DNA methylation in large cohorts. By profiling 5mC & 5hmC, we uncover trait- and cell-type-specific cytosine mod signatures across tissue, aging. doi.org/10.1016/j.xgen.2025.… #Epigenetics #EWAS #5hmC
Image from Wanding Zhou (@zhouwanding)
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Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation pubmed.ncbi.nlm.nih.gov/3822…
Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA...

Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA...

Influenza virus infection alters the promoter DNA methylation of key immune response-related genes, including type-1 interferons and proinflammatory cytokines. However, less is known about the effect...

pubmed.ncbi.nlm.nih.gov
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