Biochemist | former PhD student @KorberLab LMU | fascinated by chromatin, yeast & IDRs
München, Bayern
Joined March 2020
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Iris Langstein retweeted
We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) biorxiv.org/content/10.1101/…
I'm excited to share our new paper - an incredible multi-year collaboration with the incomparable Philipp Korber (@KorberLab) driven by one of the most impressive graduate students I've had the pleasure of working with, Iris Langstein-Skora (@ILangstein) biorxiv.org/content/10.1101/…
Iris Langstein retweeted
Disordered proteins are ubiquitous and play myriad important roles in biology. The structural form of these proteins can change when the solution environment changes. But does this translate into function? We answer this question in our new preprint: tinyurl.com/3bwm2twf
Iris Langstein retweeted
We are happy our review is out!
If you are interested in the impact of nuclear organization on antigenic variation, check it out!
We discuss the role of nuclear organization in mutually exclusive antigen expression and genome stability. rdcu.be/dic9N
@NatureMicrobiol
Iris Langstein retweeted
“I knew I should have streaked for single colonies!”
- CSHL Yeast Course t-shirt from late ’90’s
Happy summer course season!
Iris Langstein retweeted
Following the lab’s bird theme, we’re excited to present ALBATROSS; A deep-Learning Based Approach for predicTing pRoperties Of diSordered proteinS).
Direct prediction of intrinsically disordered protein conformational properties from sequence biorxiv.org/cgi/content/shor… #bioRxiv
Iris Langstein retweeted
I'm proud to introduce you to the IDRome 👋🍝
We performed simulations of 29,998 IDRs from the human proteome and analysed sequence-ensemble-function relationships.
For a quick intro watch 🎞️👇 and then read: biorxiv.org/content/10.1101/…
Iris Langstein retweeted
A team led by LMU #molecular biologist Christoph F. Kurat has demonstrated that the way in which #DNA is packaged makes a decisive contribution to a cell’s ability to efficiently double its #genome for cell division. lmu.de/en/newsroom/news-over…
Iris Langstein retweeted
I realize that I am very fortunate and lucky to have received this ERC grant, so wanted to give a bit of background for the 10-year process it has been for me to get funding from the ERC. This funding came in my fourth attempt. 1/n
I am beyond thrilled to announce that we (me 🇩🇰, Eike Schulz 🇩🇪 & Mikael Akke 🇸🇪) have been awarded an ERC Synergy Grant 🇪🇺 🎉
In #DynaPLIX we will combine NMR 🧲, time-resolved crystallography ⚡️ & simulations 🖥️ to study how ligands bind to proteins
lth.se/english/article/major…
ALT Picture of Mikael Akke, Kresten Lindorff-Larsen and Eike Schulz, the three PIs in the new ERC synergy grant called DynaPLIX.
Iris Langstein retweeted
Excited to share the first paper from my lab. We show that condensates composed of the disordered region of MED1 selectively partition specific functionally related proteins from a complex mixture of biomolecules, regulating gene activation. Free link: authors.elsevier.com/a/1gMr6…
Iris Langstein retweeted
Never promote overwork. It's not a sign of passion or dedication, it's misguided & deeply unhealthy.
Iris Langstein retweeted
One week left to register and apply for a talk at the #MunichYeastMeeting 2022 @HelmholtzMunich October 10th
helmholtz-munich.de/munich-y…
@ThePughLab @SophieMartinLab @lab_engel @Dey_Gautam #MYM2022
Iris Langstein retweeted
Our collaborative work is online today at @NatureSMB! We uncover a simple guiding rule -Conformational buffering: IDP functions are conserved despite large scale variations in sequence by conserving sequence-ensemble relationships. nature.com/articles/s41594-0…
Iris Langstein retweeted
A mentee asked if I feel bad for the authors of the original paper, particularly the trainees. My answer is: yes.
But when the record isn't corrected, more trainees suffer from picking the wrong project, approach, or interpretation of data. Correcting the record is kind to them.
In a recent paper, Shen et al. reported that most synonymous mutations in yeast genes were strongly deleterious. In a new preprint, we argue that this result is largely or entirely artifactual and arose from a lack of appropriate controls. biorxiv.org/content/10.1101/…
Iris Langstein retweeted
The Krietenstein Lab is hiring (1xPhD/ 2xPostDocs)!
Interested in the structure and function of the 3D genome? Interested in developing cutting-edge sequencing technologies and analysis pipelines? Check out this tweet! And join us in beautiful #Copenhagen @CPR_UCPH.
Please RT!!
