Fantastic news! Please correct me if I’m wrong or missing anything as I wish to have a good understanding of the RCTs in this space IP4-CHRONOS-A Focal HIFU/cryo vs surgery/RT Closed after pilot failed its feasibility criterion IP17-APOLLO Focal therapy ± 3 months neoadjuvant apalutamide Does not establish focal therapy vs radical therapy CHRONOS-B Focal therapy alone vs focal + short neoadjuvant hormonal manipulation Closed pilot. Feasible, but again not FT vs standard definitive treatment IP2-ATLANTA In de novo mHSPC: SOC vs ablative prostate treatment vs radical local therapy, with MDT strategies Fascinating, but this is cytoreduction in metastatic disease, not a test of focal therapy as definitive localized therapy PART Partial ablation vs radical treatment The most important UK RCT, but Ahmed is not the chief investigator For partial ablation, the current protocol can allow a repeat focal ablation before declaring failure. So, is there an RCT he is running that compares FT to definitive treatment? Very interested to learn more if so or be corrected if I’m off the mark. Thanks in advance and for all of the hard work!

Receipt of prostate-specific membrane antigen positron emission tomography for #ProstateCancer staging was associated with higher initiation rates of androgen receptor pathway inhibitor therapy and increased use of systemic treatment. ja.ma/4bXVb4W