International Transmembrane Transporter Society (@ITTS_Cure) profile picture

International Transmembrane Transporter Society

@ITTS_Cure

The International Transmembrane Transporter society (ITTS) is dedicated to promoting transporter biologists and transporter-related research

ittsociety.org/
Joined April 2018
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Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)Photo by International Transmembrane Transporter Society (@ITTS_Cure)
📣 We are now accepting session proposals for our 10th Anniversary meeting #ITTS_2024 Oct 29 - Nov 1 in Washington DC, USA. Proposals related to any class of membrane transporters are welcome! Deadline for submission is Jan 31. Further details on website ittsociety.org/
INTERNATIONAL TRANSMEMBRANE TRANSPORTER SOCIETY

INTERNATIONAL TRANSMEMBRANE TRANSPORTER SOCIETY

ittsociety.org
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International Transmembrane Transporter Society retweeted
Caitlin Vander Weele, PhD (@caitvw) profile picture
Caitlin Vander Weele, PhD@caitvw16 Oct 2024
Repeat after me: LAB WEBSITES MATTER! While it may seem like a nice-to-have... in today's world, it's a need-to-have. For you, your trainees, and your prospective team members. I couldn't have written this better myself: nature.com/articles/s42255-0…
Image from Caitlin Vander Weele, PhD (@caitvw)
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Zachary Freyberg (@zfreyberg) profile picture
Zachary Freyberg@zfreyberg21 Aug 2024
Honored to have our work with @AleBonifazi @anewman2014 @BarbaraSSlusher and others as #paperofthemonth and cover by @Diabetes_ADA! We created new drug tools to study how #dopamine in #brain vs #pancreas regulates blood sugar. @PittPsychiatry @NIDDKgov doi.org/10.2337/db24-0175
Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor...

Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor...

Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the periphery are key modulators of metabolism. Moreover, disruption of D2-lik

diabetesjournals.org
Diabetes, an ADA research journal 🧪 (@Diabetes_ADA) profile pictureDiabetes, an ADA research journal 🧪@Diabetes_ADA20 Aug 2024
Articles are chosen monthly 🗓️ by the editor-in-chief and are🆓to read online #paperofthemonth #diabetes ➡️doi.org/10.2337/db24-0175 @ADA_Pubs
Image from Diabetes, an ADA research journal 🧪 (@Diabetes_ADA)
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📣 📣 📣 We are excited to announce that registration and abstract submission are now open for the 3rd ITTS meeting to be held Oct 29 - Nov 1 at the @NIH campus in Bethesda, MD! See website 👇 for program and further info. ittssymposium.vfairs.com/

ITTS Symposium

ittssymposium.vfairs.com
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International Transmembrane Transporter Society retweeted
Membrane Protein PDB (@MemProtPDB) profile picture
Membrane Protein PDB@MemProtPDB19 Aug 2024
Cryo-EM structure of ACE2-SIT1 in complex with Tiagabine | Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
Image from Membrane Protein PDB (@MemProtPDB)
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Membrane Protein PDB (@MemProtPDB) profile picture
Membrane Protein PDB@MemProtPDB21 Aug 2024
Human XPR1 structures reveal phosphate export mechanism | Nature doi.org/10.1038/s41586-024-0…
Image from Membrane Protein PDB (@MemProtPDB)
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International Transmembrane Transporter Society retweeted
sookwah_yee (@sookwah_yee) profile picture
sookwah_yee@sookwah_yee23 May 2024
🎉 Exciting news! Our final manuscript is now published in @NatureComms! 📄 We reveal that the orphan human SLC22A10 gene is a unitary pseudogene due to a fixed missense mutation (P220), while its orthologs in great apes (L220) are capable of transporting sex steroid conjugates.
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Transporters and Solute carriers (@solutecarriers) profile picture
Transporters and Solute carriers@solutecarriers5 May 2024
Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2 nature.com/articles/s41467-0…
Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2

Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2

Nature Communications - SLC26A2 transports crucial ions and mutations in it cause diverse diseases. Here, authors present cryo-EM structures of SLC26A2 with substrates, revealing details of its...

nature.com
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Dimitris Kolokouris (@DKolokouris) profile picture
Dimitris Kolokouris@DKolokouris4 May 2024
Important findings on the LAT1/4F2hc heterodimer super complex formation from Robinson/Zhou labs. Super updates on the SLC7 family. PE binding sites verified with MS! nature.com/articles/s41467-0…
The complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function...

The complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function...

Nature Communications - The amino acid transporter complex LAT1-4F2hc is considered a major drug target for many cancers. Here, the authors apply native mass spectrometry-based approaches to decode...

nature.com
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International Transmembrane Transporter Society retweeted
Yeeun Son (@Yeeun_Jecy_Son) profile picture
Yeeun Son@Yeeun_Jecy_Son2 May 2024
Excited to share our study on a high-affinity choline and ethanolamine transporter, FLVCR1, published today at Nature. I am grateful for my doctoral advisor ,@HiteLabMSKCC , my co-authors and collaborators, @TimCKenny, @ArtemAKhan, and @KivancBirsoy. doi.org/10.1038/s41586-024-0…
Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Nature - A structural, biochemical and metabolomic analysis reveals the mechanistic basis for transport of extracellular choline and ethanolamine into cells by the human transport protein FLVCR1.

nature.com
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Rosemary Cater, PhD (@RosemaryJCater) profile picture
Rosemary Cater, PhD@RosemaryJCater2 May 2024
(1/8) Do you eat enough choline? Have you even heard of it?? Choline is super important for the brain and must come from your diet 🐟🥚🥦 Here @Nature we show that FLVCR2 transports choline into the brain and use #cryoEM to show how! 🧠🔬 @pippomancia nature.com/articles/s41586-0…
Structural and molecular basis of choline uptake into the brain by FLVCR2

Structural and molecular basis of choline uptake into the brain by FLVCR2

Nature - FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.

nature.com
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Simon Newstead (@inwardopen) profile picture
Simon Newstead@inwardopen18 Apr 2024
An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. rdcu.be/dE759 nature.com/articles/s41594-0… @BiochemOxford @KavliOxford
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Transporters and Solute carriers (@solutecarriers) profile picture
Transporters and Solute carriers@solutecarriers10 Apr 2024
Transport mechanism and pharmacology of the human GlyT1 cell.com/cell/fulltext/S0092…
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Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol5 Apr 2024
"A structural biologist's dream" is the caption of this Figure 😉 From a beautiful new review of cryo-EM for structural and cell biology @Nature nature.com/articles/s41586-0…
Image from Eric Topol (@EricTopol)
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Prof Renae Ryan (@renaemryan1) profile picture
Prof Renae Ryan@renaemryan14 Apr 2024
Thank you to @BiochemSoc and my nominators for this award! Science is a team pursuit and this award recognises the hard work of the talented students, early-career researchers & collaborators I am fortunate to do science with! @syd_health #TransporterBiologyGroup
Biochemical Society (@BiochemSoc) profile pictureBiochemical Society@BiochemSoc4 Apr 2024
Our 2025 International Award goes to Prof Renae Ryan at @Sydney_Science! @renaemryan1 is internationally recognised for her work elucidating the fundamental molecular mechanisms of transport proteins, ultimately transforming our understanding of transport across the cell membrane
The Biochemical Society 2025 Awards International Award Professor Renae Ryan University of Sydney

ALT The Biochemical Society 2025 Awards International Award Professor Renae Ryan University of Sydney

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Biochemical Society (@BiochemSoc) profile picture
Biochemical Society@BiochemSoc4 Apr 2024
Our 2025 International Award goes to Prof Renae Ryan at @Sydney_Science! @renaemryan1 is internationally recognised for her work elucidating the fundamental molecular mechanisms of transport proteins, ultimately transforming our understanding of transport across the cell membrane
The Biochemical Society 2025 Awards International Award Professor Renae Ryan University of Sydney

ALT The Biochemical Society 2025 Awards International Award Professor Renae Ryan University of Sydney

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Membrane Protein PDB (@MemProtPDB) profile picture
Membrane Protein PDB@MemProtPDB3 Apr 2024
Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters | Nat Plants doi.org/10.1038/s41477-024-0…
Image from Membrane Protein PDB (@MemProtPDB)
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Membrane Protein PDB (@MemProtPDB) profile picture
Membrane Protein PDB@MemProtPDB3 Apr 2024
Conformational changes in the Niemann–Pick type C1 protein NCR1 drive sterol translocation | PNAS pnas.org/doi/10.1073/pnas.23…
Image from Membrane Protein PDB (@MemProtPDB)
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Membrane Protein PDB (@MemProtPDB) profile picture
Membrane Protein PDB@MemProtPDB3 Apr 2024
Mechanical activation opens a lipid-lined pore in OSCA ion channels | Nature doi.org/10.1038/s41586-024-0…
Image from Membrane Protein PDB (@MemProtPDB)
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Cathy Spangler (@catler4ohsu) profile picture
Cathy Spangler@catler4ohsu2 Apr 2024
Happy to share a first peek at some of my postdoc work, which has been a really fun team effort with Aya, Johannes, and some other great collaborators! biorxiv.org/content/10.1101/…
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

Chemical synapses are the major sites of communication between neurons in the nervous system and mediate either excitatory or inhibitory signaling [[1][1]]. At excitatory synapses, glutamate is the...

biorxiv.org
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Charles Cox (@Charles_D_Cox) profile picture
Charles Cox@Charles_D_Cox3 Apr 2024
Excited to share our latest collaboration with the @corrylab and Zhang Lab, this time on OSCA/TMEM63 channels out today in @Nature @VictorChangInst nature.com/articles/s41586-0…
Mechanical activation opens a lipid-lined pore in OSCA ion channels

Mechanical activation opens a lipid-lined pore in OSCA ion channels

Nature - The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding...

nature.com
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