BBSRC Discovery Fellow | #CryoEM 🔬 | Phages - Antimicrobials - Host Takeover | He/Him
Joined August 2009
- Tweets218
- Following354
- Followers232
- Likes819
Jason wilson retweeted
We have a fascinating preprint just out, revealing the widespread packaging of bacterial genomic DNA into capsids in the human gut:bit.ly/3B2ajza. Major denizens of the #microbiome implicated with broad potential impact on bacterial evolution and horizontal gene transfer
ALT Concept summary of the approach used in the present study. A. Diagram of a caesium chloride gradient tube of VLPs purified from human faecal samples. Two bands of different densities are illustrated, followed by a flow chart of the Oxford Nanopore sequencing process and an illustrative chart showing read length distributions typical of phage, transducing phage particles and gene transfer agents. B. Distributions of read lengths obtained from six faecal VLP fractions.
Jason wilson retweeted
🧵one of my favorite tools: Foldseek (1/7)
We have traced the evo of species by comparing their proteins. We use models that assign a %similarity between seqs and confidently infer that 2 proteins are homologous if share ≥25% SeqSim. But what happens when it’s less than this?
Jason wilson retweeted
"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 @NatureComms #Neuroscience #Toxin #cryoEM @Sfb1348 @uni_muenster
Jason wilson retweeted
🚀Announcing my first (co)first-author manuscript 🚀
"Cell attachment and tail contraction of S. aureus phage phi812"
🔗bit.ly/Phi812
Check out the 🧵 to explore the structural details of phage interaction with Gram+ bacteria🤯
#PhageTherapy #Research #PhDlife
1/11
Jason wilson retweeted
✨️ It's been a long time coming ✨️
journals.plos.org/plosbiolog…
Really excited to finally be able to share the publication of my first first-author research paper in PLOS Biology today!
A Thread 🧵
Jason wilson retweeted
Fully funded 4-year PhD position using cutting-edge fluorescence and electron microscopy to study the bacterial cytoskeleton. 🔬🦠🦴
Co-supervised by Martin Goldberg (Durham) and Yulia Yuzenkova (Newcastle).
Apply by 22 July!
findaphd.com/phds/project/bb…
Jason wilson retweeted
In the USA in 1943 they produced a film 'Don't be a Sucker' about fascism.
It perfectly explains Nigel Farage, Suella Braverman, Tommy Robinson and the entire Right.
Jason wilson retweeted
We present DRGN-AI for fast, ab initio cryo-EM reconstruction!
* learns a neural field from unposed images,
* designed for single-shot reconstruction of unfiltered datasets,
* finds new states missed by prior approaches!
Teamwork led by @ZhongingAlong
drgnai.cs.princeton.edu/ 1/
Jason wilson retweeted
We present a preprint about a “stargate” mechanism of the capsid opening required for genome delivery in members of the Microviridae family. See below for a short manuscript summary (1/9).
biorxiv.org/content/10.1101/…
Jason wilson retweeted
Check out our latest work on #CRISPR-associated #transposons (CAST) published in @MolecularCell! 🤩
authors.elsevier.com/c/1jCED…
(1/21)
We want to thank the generous funding from @ERC_Research and @novonordiskfond
and that allowed us to complete this work
Have a look at the follow-up twetorial by @proteofrankie explaining the findings
#crispr #genomeediting #CryoEM #HorizonEU
Jason wilson retweeted
You can't find a better Postdoc opportunity anywhere else! Fantastic mentor and amazing science!
One week to go until close of applications for a postdoctoral position on phage defence with us here in Durham tinyurl.com/mvwtjvxf
Jason wilson retweeted
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
Jason wilson retweeted
👇🏼My Husband Sam is looking for new positions in the UK👇🏼, he is a brilliant scientist and would thrive in any #industry position that needs a skilled and enthusiastic #chemist! Share & DM with information about jobs⚛️Thanks for your support! #JobHunting
linkedin.com/posts/samuel-nu…
Jason wilson retweeted
Seeking scientist volunteers! Want to practice science communication and help author a ✨comic✨ about your research? I need collaborators for this spring's cohort of SciComm & Comics art students! Please share widely. #STEMeducation #Science #sciart
ALT Flyer advertising a need for scientists volunteers. "Call for scientists! Want to collaborate with an art student on a comic about your research? Learn more and sign up by Feb 1st." Simple cartoon heads are wearing hats that are designed to look like items symbolic of different scientific disciplines: an aromatic ring, a crystal, an ammonite, and a paramecium. Link: bit.ly/sciencecomicscollab
Jason wilson retweeted
Last chance to apply for one of these bacteriophage #PhDposition I am offering in collaboration with Prof. Fred Antson @BiologyatYork @YSBL_York. Opportunities to study structural, molecular, genetic and evolutionary aspects of viruses of microbes.
I am pleased to offer two exciting PhD opportunities @UniOfYork to study virus assembly, structure and genome processing. Viruses are the most abundant organisms on the planet with a massive impact on all aspects of life. Apply: bit.ly/3tqGVOJ or bit.ly/3ZJTmBx
Jason wilson retweeted
1/ I've been waiting too long to share this. variability refinement allows to refine an ensemble of PDBs in an ensemble of maps from 3DVA @cryosparc or multibody ref. in @RELION. #cryoEM.
Available in Phenix
Jason wilson retweeted
Fantastic thread by Pavol, summarizing his discovery of most likely the founding member of a new family of tail-less phages - bit.ly/3Q3UPiP @iScience_CP. Also, crucial insights into how to handle these phages that are so often overlooked due to purification biases!
Jorvik is the first characterised tailless membrane-containing dsDNA phage infecting an alphaproteobacterium. Read below the highlights of the study from @YSBL_York, @BiologyatYork and @LMDM17199375. It opens a new door to phage perception (1/7) cell.com/iscience/fulltext/S…
Jason wilson retweeted
Jorvik is the first characterised tailless membrane-containing dsDNA phage infecting an alphaproteobacterium. Read below the highlights of the study from @YSBL_York, @BiologyatYork and @LMDM17199375. It opens a new door to phage perception (1/7) cell.com/iscience/fulltext/S…
Jason wilson retweeted
.@JSamWilson (@sheffielduni) and colleagues published a new preprint on the molecular mechanism of #phage tail contraction, shedding light on the structure of an S-layer-penetrating phage.
buff.ly/48tkecS
Jason wilson retweeted
And breatheeeee … talk done 😅 The audience were amazing, so thankyou for letting me give a talk at such an awesome conference! Wouldn’t be possible without such a supportive team! #Clostpath2023 @RobFagan @PerBullough @Hannah_Fisher2 @BuddleJess
