PGY-4 in Switzerland. Interested in internal medicine, ID, clinical reasoning and research on low value care.
Joined January 2013
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AHA meeting and lipids so far:
-statins work, even in older adults
- fancy new drugs targeting IL-6 and lp(a) don't
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Jean Regina retweeted
Why am I not very excited about this?
I saw how TAVI started as an alternative for a much superior procedure in inoperative patients, they I saw how the industry gradually increased the indications.
This is a repeat DeJa vu! Do you want me to predict to you the next target?
PROGRESS presented at #TCT2026: Among patients with moderate aortic stenosis and at-risk features, a TAVR strategy was superior to clinical surveillance in reducing the 2-year incidence of death or HF events. The primary endpoint was largely driven by HF hospitalizations, in the context of an unavoidable open-label design.
A highly selected population, enriched for risk factors. Medical therapy may also have been suboptimal relative to current standards or evolving evidence. Finally, does intervening earlier in the natural history of the disease mean starting the durability clock sooner than necessary? nejm.org/doi/full/10.1056/NE…
Jean Regina retweeted
The 1st of 2 new articles in CID critical of clinical guideline process is out. See
academic.oup.com/cid/article…
It is long past time clinical guidelines incorporate the humility of uncertainty & stop creating standards of care absent of reproducible prospective studies.
@ABsteward
Jean Regina retweeted
For older adults w/ newly diagnosed afib during hospitalization the 1-yr stroke risk w/o anticoag was low: 0.7% for CHA2DS2VASc 1-4 & 1.8% for 5-8
Given consensus of ≥2%/year, anticoag may be less compelling in hospital-detected AF but should still be individualized by risk
Jean Regina retweeted
"The other evening, I received two normally welcome email alerts. The first informed me that an invitation to peer review had been accepted; the second, that a peer review had just been completed.
The problem? These two emails came seven minutes apart and concerned the same reviewer"
sciencedirect.com/science/ar…
Jean Regina retweeted
Happy new year!
To bring in 2026, let's rewind
Here are the 2025 evidence updates for hospital medicine
Paired with EBM teachable moments
Jean Regina retweeted
Rethinking the routine: Are repeat blood cultures necessary after completion of infective endocarditis treatment?
✅ Just Accepted
🔗 bit.ly/489rqwy
Jean Regina retweeted
🫀Rethinking the routine: Are repeat blood cultures necessary after completion of infective endocarditis treatment?
💡 Key takeaway: Early routine cultures in asymptomatic patients rarely catch relapses—guidelines now favor symptom-driven follow-up.
How does your team monitor post-IE patients? #IDXposts #IEWiki
Should you repeat blood cultures after treating infective endocarditis?
European and American guidelines don’t agree — but the evidence suggests you probably shouldn’t in asymptomatic patients.
Discover our brief report just published in CID!
tinyurl.com/ya3neew8
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Thin Skin in Cushing’s Syndrome | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
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Jean Regina retweeted
#TWDFNR Non-contrast head CT 👤 before LP in low-risk adult and children with suspected 🧠 ABM should not be performed and is potentially harmful 🙅
bit.ly/42jfX7A
@JHospMedicine @JeanThomasR
#VisualAbstract by @SuchitaSata
Jean Regina retweeted
#TWDFNR: Is ordering a noncontrast head CT before performing a diagnostic lumbar puncture the best call to decrease the risk of brain herniation? @JHospMedicine @JeanThomasR
bit.ly/3FJd08W
Jean Regina retweeted
🆕💥 @CMIJournal @ESCMID
Impact of 2020 EUCAST criteria on meropenem prescription for the treatment of Pseudomonas aeruginosa infections: an observational study in a university hospital #IDTwitter #medtwitter #TwitteRx #MedEd
clinicalmicrobiologyandinfec…