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Jupiter
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Joe Springer retweeted
Humans are extraordinarily sensitive to the smell of rain, known as petrichor, primarily due to the compound geosmin.
We can detect geosmin at parts-per-trillion levels, whereas sharks typically detect blood in water at parts-per-million or parts-per-billion concentrations.
This means humans are roughly 200,000 times more sensitive to the scent of rain than sharks are to blood.
Such heightened sensitivity likely evolved because smelling rain helped early humans locate fresh water and fertile environments.
What seems like a pleasant aroma today was once a crucial survival signal.
ALT Humans are extraordinarily sensitive to the smell of rain, known as petrichor, primarily due to the compound geosmin. We can detect geosmin at parts-per-trillion levels, whereas sharks typically detect blood in water at parts-per-million or parts-per-billion concentrations. This means humans are roughly 200,000 times more sensitive to the scent of rain than sharks are to blood. Such heightened sensitivity likely evolved because smelling rain helped early humans locate fresh water and fertile environments. What seems like a pleasant aroma today was once a crucial survival signal.
Joe Springer retweeted
The Arc gene (Activity-regulated cytoskeleton-associated protein) and memory engram cell are both central to the neuroscience of learning and memory, and they are functionally linked.
Arc isn’t just a plasticity gene—it forms virus-like capsids that transfer mRNA between engram cells, helps tag active synapses, and enables memory updating. Precise Arc levels are essential: too much or too little disrupts memory. Dysregulation is linked to Alzheimer’s, but targeted rescue shows promise. (Ashley, 2023; Chen, 2024; Kim, 2024)
Targeting integrins is gaining traction in Alzheimer's and dementia
Filamin A is a major gatekeeper to integrins
In its native conformation, filamin A's integrin binding site is auto-inhibited
Fix the conformation back to the native form --> stop integrin-induced Alzheimer's pathology
$SAVA
More than two decades ago migfilin showed that binding filamin A in the same general place as simufilam is possible, and modulates cell shape
$SAVA
Funny, you don't hear about the actin cytoskeleton hallmarks of Alzheimer's like cofilin and Hirano bodies
I wonder if it is because BP has no treatments related to the actin cytoskeleton?
Anyway, it seems properly shaped filamin A phosphorylates cofilin, deactivating it and preventing tauopathy
$SAVA
Thank you again, Yale!
Hot of the presses!
Yale team already demonstrated simufilam's MOA and efficacy in mouse seizures.
Now they show same MOA restores cortical synaptic connectivity.
Ya know, like in Alzheimer's disease.
$SAVA
pubmed.ncbi.nlm.nih.gov/3916…
"Nobody has seen results like that before"
Great re-recorded interview with $SAVA CEO Rick Barry
journey.ct.events/view/d574c…
$SAVA
Wow, not allowing links to Alzheimer's studies that don't tote the corporate narrative.
This along with making fake accounts of me, and all the attempts to smear the data ahead of time, show the desperation of the opposition.
I'm being impersonated by "@joespringier"
Please report and be careful.
Also, I have no idea who "Manny" is -- people are telling me a "Manny" is claiming some affiliation.
$SAVA
This Post is from a suspended account. Learn more
New 8/27/24 Biochemical Journal article proposes FLNA plays a "critical scaffolding role" in "ROCK" and "PKC". Both of which are implicated in #Alzheimers, neurodegeneration & cognitive decline. Could $SAVA #simufilam's positive affect on FLNA play a role?
Two big catalysts coming for $SAVA
First Topline Data
And Takeout
Karuna is by far the best comparator -- their takeout happened right after their safety data came in
Our safety data reveals in January
Could happen quick
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