Mitotic #genomes have their #chromosomes connected together by #DNA-based linkers with about the same spring constant as the chromos themselves biorxiv.org/content/10.64898… [also the case for 🐁 meiotic metaphase] TY for a great collaboration, Lisa Hua Lab @SSUbiology !

Published: Transcriptomics + single-DNA binding and mechanics analyses of the DNA-twisting protein GapR - doi.org/10.1093/nar/gkag729 (PMID 42516079) - thanks a ton to Monica Guo and Lucy Kwiatkowski for a great collaboration!

Enjoy our new paper - how molecular crowding as in vivo changes polymer mechanics of semiflexible polymers like double stranded #DNA - thanks to a wonderful collaboration with @ParitoshGupta and @VittoreScolari journals.aps.org/pre/abstrac… or biorxiv.org/content/10.64898…

Enjoy this preprint from a great collaboration with the @VittoreScolari - molecular crowding and #DNA stat mech biorxiv.org/content/10.64898… #biorxiv_bioinfo #physics - this project started on a blackboard at the @IES_Cargese - thanks to the @CNRS for a terrific meeting!

GapR is an amazing little protein from Caulobacter crescentus that vigorously overtwists DNA, helping the bug deal with positive supercoiling from transcription and replication - result of wonderful collaboration with @monicasguo biorxiv.org/content/10.64898…

Enjoy Dr. Parth Desai's recent study of the suppression of DNA strand separation by molecular crowding pubmed.ncbi.nlm.nih.gov/4031… #biophysics #singlemolecule #DNA

Commemorate the life and science of our dear departed colleague Jon Widom - this Thurs May 15 1230 pm in Pancoe Auditorium @NUmolbiosci @NorthwesternU - our distinguished Widom Lecturer is Prof. Lucy Bai @penn_state - Chromatin Accessibility and the 3D Genome

Why did the US government decide to start funding science and training young scientists? Worth reading this answer written in 1945 - for the moment still posted on the @NSF website at nsf-gov-resources.nsf.gov/20…

Subchromosomal mechanics of pericentric and centromeric chromatin along stretched mitotic chromosomes - surprise is little effect of CENP-N and -C degradation on CENP-A organization pubmed.ncbi.nlm.nih.gov/3993… From Ron Biggs and @StraightLab #centromere #kinetochore #chromosome

In case anyone is left out there, I'm pleased to report that Dr. Ning Liu's paper on mechanics of meitotic metaphase chromosomes, dependence on #cohesin #aging and #toxins was just published in eLife elifesciences.org/articles/9… Enjoy!

Just returned from the Topoisomeases in Biology and Medicine meeting case.fiu.edu/news-events/top… Thanks so much to organizers Yuk-Ching Tse-Dinh, Dagmar Klostermeier, Valerie Lamour @valeroche and John Nitiss for running a great meeting!

To avoid piles of corporate nonsense in every new tab in Edge I embarked on a quest to have new tabs load a user-defined URL. Apparently possible only by adding a 3rd-party browser extension, e.g., microsoftedge.microsoft.com/… It works but I'm sure the victory is only temporary.

Dr. Ron Biggs has set up a really great #YouTube library of #chromosome manipulation movies plus some lab classics - including detailed video protocols. Let us know if you find them useful! youtube.com/channel/UC980JA2…

Ban assault weapons now. sign.moveon.org/petitions/ba…