@KawakamiLab

We are studying cellular mechanisms of Multiple Sclerosis, especially focusing on autoreactive T cells

Joined December 2020
  • Tweets13
  • Following52
  • Followers114
1Media
We’re looking for a motivated #PhD with a strong interest in #CRISPRCas9, #Tcells, and #autoimmunology! 🧠🧫🧪 Check out the details and how to apply: neuroimmunology-munich.de/op… Please RT to help us spread the word!✨
1
2
207
We are excited to share our collaborative work with @LabPeters is freshly published in Science Immunology!🥳✨🧠 We revealed the detailed mechanism of T–B cell interactions in meningeal eLFs in the mouse model of MS.👏💪 Check out the full paper here: science.org/doi/10.1126/scii…

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.

science.org
4
8
414
We've published a News & Views article on an exciting new discovery by KIM et al.! 🧠✨ Peptides from myelin proteins protect brain by regulating T cells function and suppressing autoimmunity in the brain👏💪 Read more: rdcu.be/d2pis @NatureNV
4
108
And check out the N&V from Magda Ali and @LabListon nature.com/articles/s41593-0…
4
1
14
5,792
🔬 Exciting news! Our latest paper, together with @Ker_Lab, is out now in @NatureNeuro ! 📚 We conducted a genome-wide in vivo #CRISPR screen to uncover regulators of T cell migration into the CNS in a multiple sclerosis model. Check out the details! 🐀🧬nature.com/articles/s41593-0…

A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS...

Nature Neuroscience - Multiple sclerosis (MS) lesions are initiated by the infiltration of T cells to the CNS. Here, Kendirli et al. use a genome-wide CRISPR screen in an MS model to define the...

nature.com
1
12
41
3,405
Check out our latest research published in @PNAS 🎉🔬Using our intravital imaging approach, we provide direct footage of microbiota-mediated T cell activation in the ileal lamina propria resulting in phenotypical changes of the encephalitogenic T cells. pnas.org/doi/10.1073/pnas.23…

Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo...

Autoreactive encephalitogenic T cells exist in the healthy immune repertoire but need a trigger to induce CNS inflammation. The underlying mechanis...

pnas.org
5
6
1
32
2,268
Congratulations to @LabMader on their new publication! 🥳It was a pleasure to contribute. Take a look at the pathomechanisms of MOG-antibody-associated disease: pnas.org/doi/10.1073/pnas.23…
1
3
7
696
KawakamiLab retweeted
Meinl Lab@LabMeinl18 Feb 2022
Are you curious about translational neuroimmunology? We are looking for a highly motivated PhD student or Post-Doc to join our lab. Please RT! bmc.med.uni-muenchen.de/news…
1
7
1
8
Exciting work by Behrens et al.! Congrats to Vigo Heissmeyer with his team and to all collaborators. It was a pleasure to contribute.
Nature Immunology@NatImmunol22 Nov 2021
Mutations in the RNA-binding proteins Roquin-1 or Regnase-1 cause systemic autoimmunity. Behrens et al show that Roquin-1 and Regnase-1 physically interact and thereby regulate CD4+ and CD8+ T cell metabolism and functionality. rdcu.be/cBOSX @LMU_Muenchen
1
Congratulations to @korn_lab on their outstanding work, which is now published in @NatImmunol! 🥳 We really enjoyed being part of the team. Take a look on how the site of peripheral T cell priming defines their effector phenotypes in CNS autoimmunity: nature.com/articles/s41590-0…

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central...

Nature Immunology - Korn and colleagues demonstrate that the site of T cell priming (gut versus skin draining lymph nodes) dictates their effector phenotypes and homing to distal sites of...

nature.com
4
Finally our new website is online 🤩 Check it out here: neuroimmunology-munich.de/ou…
2
We are glad to be part of this interesting joint project of the Dornmair Lab of @INIM_Munich and colleagues from @NeuroimmunoCBR on the resurrection of a pathogenic immune response from a unique patient who died in 1958 from autoimmune encephalomyelitis: pubmed.ncbi.nlm.nih.gov/3324…

Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case...

Aim of our study was to identify the target auto-antigen in the central nervous system recognized by the immune system of a unique patient, who died more than 60 years ago from a disease with...

pubmed.ncbi.nlm.nih.gov
1
We are happy to share our latest publication together with @LabMeinl on the novel CNS autoantigen OMGP. Well done, Ramona!
Meinl Lab@LabMeinl2 Dec 2020
Congratulations to our postdoc Ramona Gerhards for the exciting work on a novel target for autoimmunity in the #CNS You can now read how OMGP Abs improve patients stratification! rdcu.be/cbAUh #autoimmunity #inflammation #CNS
4
Load more