PhD Cancer Biology UIC Chicago, IL
Joined April 2022
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Could not be prouder of this work or more grateful to the whole team for this one. Shoutout to @ColoffLab for this original meme that *perfectly* summarizes the paper. Check out the final print here: ASCT2 is a major contributor to serine uptake in cancer cells: Cell Reports
Excited to announce my successful dissertation defense! It has been an incredible experience at UIC @ColoffLab
Kelly Conger retweeted
ASCT2 is the primary serine transporter in cancer cells biorxiv.org/cgi/content/shor… #bioRxiv
Serine metabolism in cancer is well-understood and appreciated, but the identity of serine transporters has been a missing piece of the puzzle for too long...Check out my new preprint to find out more! 🧵
Thank you to the entire @ColoffLab for this one!
biorxiv.org/content/10.1101/…
Huge thank you to @chidley_chris, @LabDeNicola, and @bensahralab for all of your help along the way.
🧵5. Finally, we find that loss of ASCT2 in combination with a serine-free diet leads to tumor regression in a xenograft model of ER+ breast cancer!
🧵4. We find that serine uptake through ASCT2 is critical for purine nucleotide biosynthesis, and characterize a novel mechanism of regulation by ER!
🧵3. If you've heard of ASCT2, its likely in the context of glutamine uptake. We show that glutamine and serine actually compete for uptake by ASCT2!
🧵2. We show that ASCT2 contributes to serine uptake in both auxotrophic and non-auxotrophic cell lines...
🧵We use a transporter-specific CRISPR screen to identify ASCT2 (SLC1A5) as the dominant serine transporter in luminal/ER+ breast cancer cells...
Kelly Conger retweeted
We are looking for an Assistant or Associate Professor who works at the intersection of cancer metabolism and tumor microenvironment. Link Below!
uic.csod.com/ux/ats/careersi…
Such a cool paper and so proud to be a part of it. Go @ColoffLab !!!
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Guest Editorial: Bias in Mass Spectrometry Technical Support pubs.acs.org/doi/10.1021/jas…
