
Research associate connecting anthropology and ancient DNA at @harvardmed & @HarvardHEB. Avid runner, yoga-doer, beer aficionado, mediocre vegetarian.
Boston, MA
Joined August 2018
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Also important is that no paper out of the Reich Lab lives behind a paywall, including Akbari et al. which can be accessed here: reich.hms.harvard.edu/sites/…
All papers published by our group: reich.hms.harvard.edu/public…
Kendra Sirak retweeted
David massively revised his preprint. Check out the new version!
Some highlights are more evidence for why range expansion specifically works better than an admixture pulse and what genes may have been inherited from the expanding "mode 3" population
biorxiv.org/content/10.64898…
Kendra Sirak retweeted
I'm thrilled to be the Guest Editor of the new @NaturePortfolio Collection on "𝙃𝙪𝙢𝙖𝙣 𝘼𝙙𝙢𝙞𝙭𝙩𝙪𝙧𝙚 𝙖𝙣𝙙 𝙈𝙞𝙜𝙧𝙖𝙩𝙞𝙤𝙣". This cross-journal collection includes publications in @CommsBio, @SciReports, @NatureComms & @NatureGenet.
+Info here:
communities.springernature.c…
Kendra Sirak retweeted
The paper describing the compatibility SNP set has been released!
This is a set of SNPs which reduces biases between 1240K and shotgun data while preserving maximum power. If you want to tune the dial between power and 1240K-Shotgun bias, Romain created a way of generating one.
Kendra Sirak retweeted
Very excited to present a preprint of the first chapter of my thesis, which focuses the end of the LGM (Ice age / Last Glacial maximum) in Europe, and specifically the post-LGM Balkans.
Kendra Sirak retweeted
This was just published!
Ancient samples from Ladakh show that North Indian ancestry had already formed by at least 2800 years ago. Not surprising, but its another line of evidence against fringe ideas that Indian Steppe ancestry came from Scythians or similar recent groups
Ancient genomes from Ladakh reveal 2800-year-old mixture between Tibetans and South Asians
biorxiv.org/content/10.64898…
Really cool work that builds upon and expands our 2020 paper showing optimal DNA preservation in ear ossicles. We use ossicles as our starting material whenever possible, and so should you! 💀🧬💀
genome-cshlp-org.us1.proxy.o…
New paper led by @BongersJacob!
nature.com/articles/s41467-0…
Another awesome paper resulting from the Harvard/23&Me collaboration, led by @EadaoinSays! This work presents genomic data from 49 colonial settlers from
@HistoricStMarys, the founding settlement of Maryland!
I'm thrilled to share our new paper out today in @CurrentBiology! I teamed up with researchers at @harvardmed / @HarvardHEB and @smithsonian to study another historical American population using the @23andMeResearch genetic database. 🧵 [1/9]
Read it here: cell.com/current-biology/ful…
Kendra Sirak retweeted
Qiaome Fu's lab continues to deliver when it comes to paleoproteomics from archaics! New ancient protien data from six ~400,000 year old Chinese archaics. They suggest that these samples may have been superarchaics, a deeply diverged lineage which contributed to Denisovans
Kendra Sirak retweeted
two weeks after his death, Craig Venter is a co-author on one more paper, this one a preprint describing an improved assembly of his own genome medrxiv.org/content/10.64898…
Kendra Sirak retweeted
David Reich is back.
He and collaborator Ali Akbari just published a paper that overturns a long-standing consensus about human evolution — that natural selection has been dormant in our species since the agricultural revolution.
By scaling ancient DNA sequencing and developing a new statistical method, they found that selection has actually sped up.
Selection went especially bonkers during the Bronze Age (around 3,000 years ago).
That's when gene frequencies for everything from immune function to body fat to intelligence were most in flux.
Over the last 10,000 years, selection pushed the genetic predictor of cognitive performance up by roughly a full standard deviation — most of it between 4,000 and 2,000 years ago.
After we finished recording, David sketched out on a whiteboard his new heretical model about who the Neanderthals really were. Luckily, I took out my iPhone and managed to record it.
He thinks the standard story (that Neanderthals are some separate archaic lineage we interbred with a little) just doesn't fit the evidence. Instead, he proposes that Neanderthals are essentially genetically-swamped modern humans.
A small population somewhere around the Caucasus invented Middle Stone Age technology roughly 300,000 years ago and expanded outward. The ones that moved into Europe interbred with local archaic humans, got genetically swamped, and became Neanderthals. The same expansion went into Africa, met much more diverged archaic Africans, and that mixture became us.
This means Neanderthals and modern humans share the same cultural ancestry — the only difference is which archaic humans they mixed with afterward.
David is a brilliant and rigorous scholar. It was a real delight to learn from him again.
0:00:00 – Ancient DNA suggests strong selection over last 10,000 years
0:16:24 – Natural selection intensified during the Bronze Age
0:35:40 – Why didn't evolution max out intelligence?
0:58:00 – Evolution is limited by time, not population size
1:09:40 – Why no farming before the Ice Age?
1:17:52 – The Neanderthal puzzle David can’t stop thinking about
1:54:40 – The methodology behind this breakthrough
Kendra Sirak retweeted
Ancient samples may have haplotypes poorly represented in modern samples, making it harder to impute them. How helpful is it to add high coverage ancients to imputation panels? A new preprint addresses this via real data and simulations.
Read it here: biorxiv.org/content/10.64898…
Kendra Sirak retweeted
Angola is unreal. I’m so excited for what’s to come 🤞🤠🧬☠️
#archaeology #anthropology #AcademicTwitter #DNA
Kendra Sirak retweeted
🚨 Check out our new paper in Nature!
In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵
nature.com/articles/s41586-0…
Kendra Sirak retweeted
Your ancestors aren't who you think they are | David Reich: Full Interview
youtube.com/watch?v=a0uKLW07…
Kendra Sirak retweeted
New review article from Janet Song, Michael Greenberg, David Reich and @ChrisAWalsh1 about how we can learn about the evolution of our brain, and what makes us unique compared to our closest living (ie Apes) and extinct (ie Neandersovans) relatives.
Kendra Sirak retweeted
Interview with David about the new study on selection in West Eurasia by him and @aliakbari23. Definitely worth a listen
Its finally out! Over 8 years of work by @aliakbari23 shows that selection was pervasive in the last 10,000 years, including for quantitative traits. This was directional selection. Simulations show background selection, etc can not produce the observed patterns.









































