Professor of Control Theory and Systems Biology at ETH Zürich. Theoretical and experimental methods in biology. Synthetic Biology. Cybergenetics.
Zurich, Switzerland
Joined April 2018
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How do biological networks maintain tight regulation of variables while being subjected to an onslaught of perturbations?
We establish simple universal principles for maximal robust adaptation in all biomolecular systems.
pnas.org/doi/10.1073/pnas.22…
#sysbio #synbio #cybergenetics
New preprint: Engineering Cybergenetic Cell-Based Therapies
We introduce a control framework for closed-loop cell therapies: engineered human cells that sense disease signals, compute control actions, and autonomously regulate therapeutic output.
doi.org/10.64898/2026.01.16.…
Are you looking for a versatile and inexpensive illumination platform for optogenetics experiments?
Check out our new DIYA device... It's become the most popular platform in our lab for bacterial, yeast and mammalian optogenetics.
#synbio #optogenetics
doi.org/10.1016/j.isci.2023.…
Credit to the great team of authors, especailly @santkumar_14 @anastassov for doing a marvelous job designing, building, and putting Diya to good use in the lab!
Our new home across the Rhine...! 🌟
We are very proud to be moving into a building which wins the #iconicaward for its #architecture > u.ethz.ch/7AOCm
@ETH_en #NicklPartnerArchitekten
ALT Viet into the atrium of BSS. Photo: ETH Zürich / Achim Birnbaum
Mustafa Khammash retweeted
We are very proud to be moving into a building which wins the #iconicaward for its #architecture > u.ethz.ch/7AOCm
@ETH_en #NicklPartnerArchitekten
ALT Viet into the atrium of BSS. Photo: ETH Zürich / Achim Birnbaum
Looking for opportunities in synthetic biology? Come join our team!
Doctoral positions in mammalian synthetic biology for cell-based therapies.
@ETH_BSSE @ETH
jobs.ethz.ch/job/view/JOPG_e…
Mustafa Khammash retweeted
At this year's #Scientifica23, researchers from the D-BSSE @KhammashLab organise a workshop for teenagers and young adults to learn about control theory and systems biology > scientifica.ch/event/control…
Please share and don't forget to book your free ticket!
Overflowing with gratitude for the incredible chance to push forward our cybergenetics research and pave the way for transformative medical applications. 🌟🧬 Exciting times ahead! #cybergenetics #syntheticbiology #controltheory
Congratulations to @KhammashLab & @mapo1 for receiving Advanced Grants from the Swiss National Science Foundation (@snsf_ch)!
brnw.ch/21wBJ9E
#SNSFGrant #SNSF #SNF
Mustafa Khammash retweeted
@allison_saul_ explains how "Diamond IFFLs are a Signaling Decoder's Best Friend" in the latest UDS Writing Club post! Summary of a dazzling paper by @DbenzingerD & Serguei Ovinnikov in the @KhammashLab 💎 kwrogers-lab.org/uds-writing…
Mustafa Khammash retweeted
Last week I was reminded by Arthur Lander of one of my very favourite papers on the control of robustness and stemness in cellular circuits, together w @KhammashLab bmcbiol.biomedcentral.com/ar…
Homeostasis as an emergent property of #CellularNetworks #NotInTheGenes
Mustafa Khammash retweeted
1/n New Hanna lab PREPRINT: "Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs"
biorxiv.org/content/10.1101/…
Mustafa Khammash retweeted
Congratulations to Sarah Nadeau @TanjaStadler_CH and Joaquin Gutierrez @KhammashLab on receiving the #ETHmedal for their excellent doctoral theses on advancing pathogen phylogenies for public health and developing a bacterial growth platform > u.ethz.ch/tHJvb+
@ETH_en
Mustafa Khammash retweeted
Our study on synthetic genotype networks (sets of gene regulatory networks connected by small mutational changes) is now published! Congratulations to all co-authors! @santosmoreno_j @ETasiudi @hadiastri_k @CSB_ETHZ @DMF_unil.
nature.com/articles/s41467-0…
Mustafa Khammash retweeted
A new #inControl episode is live!🔥 Can we control gene expressions?🧬 What does milk fever in dairy cows have to do with control theory? 🐄 Join us as we dive deep into the emerging field of #Cybergenetics with @KhammashLab and explore the intersection of biology and control.🔬
Optogenetic feedback control of the unfolded protein response (UPR) in yeast can significantly increase the yield of a difficult-to-fold protein. #synbio #optogenetics
authors.elsevier.com/a/1gl%7…
Credit to @moritzctsb and @DbenzingerD & thanks to @ETH_en @ETH_BSSE @ERC_Research
Great work by @St_Anastassov, @MauriceFilo, and @Ch_Hs_Chang showing how to engineer high dynamic-range integral feedback controllers using inteins to achieve robust perfect adaptation in mammalian cells!
Check out our work in the @KhammashLab on building #integral controllers genetically with split #inteins! (Play the video with sound on for an animation of a genetic circuit!)
nature.com/articles/s41467-0…
Special thanks to my coauthors @St_Anastassov, @Ch_Hs_Chang & @KhammashLab 1/5