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Quick takes on the Social Signals from #ASCO26.
🧬 RASolute-302: @marklewismd 's tweet regarding the standing ovation for RASolute-302 really made that trial stand out. The momentum here was massive, fueled by high expectations from the @RevMedicines PR, #AACR26 presentations,and the high-profile Ben Sasse interviews.
⚔️ PROTEUS: One of the more interesting trials from a social media perspective, as the radiation oncology community on X was highly critical of the trial's surgical paradigm.
🔄 CROWN: Felt a bit like an incredible replay of the Plenary from years ago—steady, practice-confirming data.
🎬 HARMONi-6: Perhaps the most compelling narrative twist. The discussant, Dr. Julie Brahmer, masterfully set up the Plenary audience using The Devil Wears Prada as a research metaphor. It begs the question: Is VEGF back?
🚀 LIBRETTO-432: A massive surprise for many attendees. Lung cancer specialists were thrilled about @LillyOncMed selpercatinib in the adjuvant setting for RET-positive NSCLC. The core takeaway from @christine_lovly presentation was loud and clear: "This is why we test."
🔬 OPTIMA: Really got the breast cancer community excited about using @Veracyte 's test to safely reduce the chemotherapy burden for many of their patients.
📦 WU-KONG28: Had such an interesting vibe. Great data from @Dizal_Global , but it leaves the KOLs asking the same commercial question: Why isn't this readily available to patients in the US yet?
Follow the #ASCO26 Pre and Post highlights here: kolpulse.com/kol-pulse-asco2…
RT @Dr_RShatsky: The worst part about the Switch trial proving what knew to be true about payload resistance is that ADCs are basically all…
“Rightly points out lack of crossover in a study with a PFS endpoint as unjust.” — @StephenVLiu on @BenjaminBesseMD's KRASCENDO-1 discussion (@Genentech)
#ESMO26 Day 3 roundup: KRASCENDO-1, SAFFRON, HARMONi-GI1, CLARITY-Gastric01, PERSEE, LITESPARK-012
hubs.ly/Q04CgNjB0
KOL Pulse AI retweeted
🆙#ESMO26 Proffered Paper II: #LCSM Mets
🔥HERON-Lung01: Ruzaltatug Rezetecan, a HER3-Directed ADC, vs Platinum-Based Chemotherapy (PBC) in EGFR-Mutated Advanced NSCLC Progressing After EGFR-TKI: Interim Analyses (IA) From the Phase 3 Trial
🎙️Dr. Chongrui Xu
🔢LBA72
🎯Met Primary Endpoint: BICR-PFS 8.3 vs 5.4mo (HR 0.47, p<0.0001; n=498)
🎯ORR 60.0% vs 34.3%
🎯OS Immature, Favorable (HR 0.70)
🎯Grade≥3 TRAEs 40.7% vs 38.9%; ILD 2.4%
☑️NCT06671379
🔗 cslide.ctimeetingtech.com/es…
@OncoAlert @Larvol @myESMO @IASLC @EGFRResisters
🆙#ESMO26 Proffered Paper II: #LCSM Mets
🔥HERON-Lung01: Ruzaltatug Rezetecan, a HER3-Directed ADC, vs Platinum-Based Chemotherapy (PBC) in EGFR-Mutated Advanced NSCLC Progressing After EGFR-TKI: Interim Analyses (IA) From the Phase 3 Trial
🎙️Dr. Chongrui Xu
🔢LBA72
🎯Met Primary Endpoint: BICR-PFS 8.3 vs 5.4mo (HR 0.47, p<0.0001; n=498)
🎯ORR 60.0% vs 34.3%
🎯OS Immature, Favorable (HR 0.70)
🎯Grade≥3 TRAEs 40.7% vs 38.9%; ILD 2.4%
☑️NCT06671379
🔗 cslide.ctimeetingtech.com/es…
@OncoAlert @Larvol @myESMO @IASLC @EGFRResisters
KOL Pulse AI retweeted
Oral abstract #BreastCancer session at #ESMO26: presented by super @CristinaSaura3 additional impressive data from DESTINYbreast09 on efficacy of first-line anti-HER2 #TrastuzumabDeruxtecan plus #pertuzumab in patients with brain metastases
@OncoAlert @myESMO
KOL Pulse AI retweeted
OptiTROP-Breast01:
Sac-TMT improved median OS in pretreated mTNBC (14.7 vs 9.9 months; HR 0.60), reinforcing the role of ADCs in later-line treatment.
@OncoAlert #ESMO26 #ESMOAmbassadors #ESMOcommunity @myESMO #BreastCancer #bcsm
KOL Pulse AI retweeted
#ESMO26 Highly recommend watching Dr. Tina Cascone in this lung education session for a mechanistic view of novel immunotherapy agents. Clear explanation of how function follows structure, the science behind bispecifics and trispecifics - combinatorial vs obligate. Watch online - tremendous resource for anyone involved in the space. #ESMOAmbassadors
KOL Pulse AI retweeted
Replying to @kazuki_nozawa
@kazuki_nozawa
能澤先生が、日本を代表してオーラルで発表してます。
2年以上CRまたはPRの方でctDNAを継続フォロー。
測定できた37例の30例はctDNAがずっと陰性。
こういった方々が治療を止められるかが今後の検討と。
素晴らしい発表。
ESMO openへも同時発表。
#ESMO26
KOL Pulse AI retweeted
☢️ #ESMO26 | Radioligands are moving well beyond PSMA & SSTR!
🎯 New targets: DLL3, FAP, CAIX…
▪️Think ADC architecture, but swap the payload for a radionuclide
⚠️ Biggest ceiling? Manufacturing, dosimetry & regulation
The biology is exciting, now logistics need to stop being radioactive….
@OncoAlert @OncoReporte @myESMO @_SEOM
KOL Pulse AI retweeted
#ESMO26 Dr. Chongrui Xu presents phase III HERON-Lung01 trial: ruzaltatug rezetecan (HER3 ADC) vs platinum chemo in EGFR NSCLC post TKI. ADC superior: PFS 8.3 vs 5.4m, HR 0.47 with OS trend (HR 0.70, ns) despite crossover. RR 60% vs 34% Low rates of discontinuation, ILD rate 2.4% and most toxicity hematologic. #ESMOAmbassadors
KOL Pulse AI retweeted
Fantastic data by @drsarahsam in #BRIDGET showing the activity of #tucatinib in pts with 🧠 mets....used in combo w/ standard therapies..building upon what we saw in HER2CLIMB.
⬆️ unmet need!
#ESMO26
#ESMOAmbassadors
@OncoAlert
#ESMO26: Practice-changing improvement in intracranial progression-free survival seen with the addition of tucatinib to standard therapy in HER2-positive metastatic #BreastCancer (#MBC) in the BRIDGET #ClinicalTrial.
Read more ow.ly/Gc4550ZZO6K
#InsightsbyESMO
KOL Pulse AI retweeted
#CHARISMA translational study
Paolo Tarantino先生から、非常にADCの耐性機序を検討するために重要なTRが報告されました。
T-DXd、sacituzumab govitecan(SG)の投与前後に採取した転移性乳癌26例の生検検体を用いて、ゲノム解析、IHC、質量分析によるプロテオミクス解析が行われました。
HER2発現低下T-DXd後の8/14例(57%)
HER2完全消失認めず。全例でIHCまたは質量分析により検出可能
TP53変異の新規検出3/15例(20%)
ABCB1/ABCC1コピー数増加3/8例(37.5%)
ABCB1タンパク増加5/7例(71%)
ABCC1タンパク増加4/7例(57%)
MAN2A2タンパク減少5/7例(71%)
耐性機序として重要なのは下記です。
T-DXd耐性獲得後でもHER2が完全には消失していなかった
薬剤排出トランスポーターABCB1/ABCC1の増加、糖鎖修飾に関連するMAN2A2の低下が確認された
前臨床実験では、ABCB1/ABCC1の過剰発現により細胞内ペイロード濃度とT-DXd感受性が低下し、MAN2A2を抑制するとT-DXdの結合・内在化が減少しました
このため、今回の研究は標的抗原の減少だけでなく、薬剤排出やADCの細胞内取り込み障害が耐性に関与することを、患者検体と機能実験の両面から支持しています
#ESMO26
現時点、Paoloのこの素晴らしい研究発表のESMOの抄録が、ESMOのページでなぜか見えない問題があります。
@PTarantinoMD
TOP1-ADCの抵抗性メカニズムを模索するマルチオミクス解析。
ABCB1/ABCC1が薬剤の排出に、MAN2A2が取り込みに関与して抵抗性に関わっているかも。
#ESMO26
KOL Pulse AI retweeted
‘5 out of 5’ phase 3 wins for BMS’ bispecific ADC iza-bren. So why hasn’t CMO Cristian Massacesi matched one of those China successes with a global phase 3 yet? #ESMO26 fiercepharma.com/pharma/bris…
KOL Pulse AI retweeted
DESTINY-Breast09: In 61 patients with baseline brain metastases, CNS-PFS HR was 0.26 for T-DXd + pertuzumab vs THP; CNS response 51.6% vs 26.7%. Exploratory analysis in inactive/stable BMs. Impact on 1L choice? @VHIO @OncoDaily @OncoAlert #ESMO26
KOL Pulse AI retweeted
DESTINY-Breast09 CNS Analysis
Assessment of pts with BICR-assessed brain mets (treated and asymptomatic or clinically inactive)
n=61
Deeper systemic and CNS response, and higher iORR
@OncoAlert #ESMO26
KOL Pulse AI retweeted
A new era for EGFR-mutant NSCLC?
Two phase III trials, two promising ADCs, and potentially a major step forward for patients progressing after EGFR TKIs!
Izalontamab brengitecan (EGFR × HER3) and ruzaltatug rezetecan (HER3) are reshaping the treatment landscape.!
Exciting science at #ESMO26!
#ESMOAmbassadors #LungCancer #NSCLC #EGFR #ADC #ESMO26
#ESMO26: In phase III trials, izalontamab brengitecan (#BispecificADC targeting EGFR and #HER3) and ruzaltatug rezetecan (#ADC targeting HER3) showed significant efficacy in patients with locally advanced or #metastatic #EGFRmutant #NSCLC
🔗 ow.ly/qpgc5100JU5
#InsightsbyESMO
KOL Pulse AI retweeted
Very nice discussion by Antonio Llombart
@OncoAlert #ESMO26
KOL Pulse AI retweeted
🔥 Outstanding piece of work published today in Nature Medicine!
Huge congratulations to @MartinReck2 ,@NadalErnest , @DoctorJSpicer and @AndrearicFili , and the entire MDT-BRIDGE team on this important publication! 👏👏
The phase II MDT-BRIDGE trial, investigating neoadjuvant durvalumab plus chemotherapy in resectable or borderline resectable NSCLC, tackles a clinically relevant question: how can we push the boundaries of multidisciplinary treatment and offer more patients a chance of curative-intent therapy?
This is exactly the kind of collaborative clinical research we need: challenging established boundaries, asking meaningful questions, and ultimately striving to improve outcomes for our patients.
Congratulations to everyone involved! 👏
🔗 nature.com/articles/s41591-0…
Happy to continue sharing exciting advances in lung cancer research as an #ESMOAmbassadors
#ESMO26 #NatureMedicine #LungCancer #NSCLC #ThoracicOncology #Immunotherapy #ClinicalResearch #MultidisciplinaryCare #CancerResearch





































































