
Konrad kording, @Penn Prof, deep learning, brains, #causality, rigor, https://xitter.cf/t.co/tTJW05RRfa, https://xitter.cf/t.co/qf7ZHxjaK1, Transdisciplinary optimist, Dad, Loves outdoors, 🦖
Philadelphia, PA
Joined November 2012
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Kording Lab 🦖 retweeted

Mark Histed@HistedLabOct 21
United States!
United StatesConnected via United States App StoreLocation may be affected by a proxy or VPN.Account-level information, not a live location or per-post device.
One gram! One-photon (not two-photon) mesoscope.
Cool work.
Our recent work presents a 1-gram wireless mesoscope for cortex-wide imaging at single cell resolution in naturally behaving mice, published in @Nature . It's interesting to see large-scale neural activities in multiple mice within a very natural habitat. rdcu.be/iGFq4KbdWuza
Kording Lab 🦖 retweeted
If governments tax AI to limit mass unemployment: tax data centers, not tokens.
Taxing AI investment (data centers) can lower peak unemployment. Taxing AI deployment (tokens) mostly delays it.
Either way, a second-best, temporary tool.
From my @IMFNews panel 🧵
Kording Lab 🦖 retweeted
I created a mock-up for a preprint server called the 'Test of time' which serves as an evidence-record for each article in perpetuity.
test-of-time-preprint.netlif…
Given that science is speeding up, we need a place to track the strength of collective scientific evidence.
I'm actually saying that I think in the future the two aren't necessarily distinct processes. But there's no need to suggest that #2 should delay #1, as if these are entirely different dialogues. I understand your concern about not conflating technical review with PR/random hot takes. And that's a thing that I think we should be thinking about how to solve. I don't think that gating through journals is a solution that has in the past adequately addressed this. Nor do I think it will stand the test of time given the pace of modern technology and the fact that science is increasingly moving outside the walls of Academia
Kording Lab 🦖 retweeted
Grant Sanderson (@3blue1brown) is the most influential mathematician of the 21st century.
Kording Lab 🦖 retweeted
OpenAI’s faster Fourier transform is less a mathematical breakthrough and more a malicious exploit of mathematical traditions.
argmin.net/p/faster-fourier-…
Kording Lab 🦖 retweeted
Spicy take incoming. 🔥🔥
The combined bomber offensive in WW2 finally crippled the Axis powers by destroying their fuel supply chain. Then it took the industrial might of the entire US to build tens of thousands of bombers.
Now anyone between you and the Middle East can burn down a refinery, tank farm, pipeline, or tanker, with an easily assembled robotic flying bomb that costs less than my AI subscriptions.
@PeterZeihan predicted "the tanker war" would happen in the Indian Ocean but it doesn't matter where. There's only one country that could plausibly enforce global peace on shipping lanes and only one industrial power that is self sufficient on oil supply, and it's the same country.
Trump asks Iran and Zelensky to please stop blowing shit up for five minutes, but the primary victims of this phase of the kinetic conflict are China and Europe, both places that have spent decade(s) ignoring and/or undermining the Pax Americana and, in Europe's case, going out of their way to destroy their own economies.
China wants to be a big boy on the global stage? Let them spend their own blood and treasure pacifying the Middle East.
Europe wants to stick it to Trump? It's easier to tell the yanks to get fucked if you don't rely on them for literally every aspect of your industrial infrastructure and economic stability.
I've been in rooms with senior energy ministers from Europe and China. The Chinese are rational and pragmatic, the Europeans are functionally comatose, but neither party has a better plan than getting into a bidding war to buy whatever LNG the US can spare, forever.
It is blindingly obvious to me that the least unstable future equilibrium is one where oil users localize supply using solar synthetic fuel tech, essentially a silico-industrial form of farm-to-table agriculture. Short supply chains, locally secured.
It is equally obvious to me that a generation of people who grew up in the "developed" world are going to endure a decade or more of severe hardship before they, collectively, accept the L and move to the next step. Most people would rather watch their neighbor freeze than admit they were wrong.
If you can't defend your entire oil supply chain from anyone who could possibly have access to a $2000 drone and could possibly have any reason to use it with zero consequences, you are one third party misunderstanding away from abruptly re-entering the pre-industrial age.
Kording Lab 🦖 retweeted
Check out this loser!
>uploads a draft to Chat on Sept. 8th
>gets scooped by Chat on Oct. 6th
"The result released by OpenAI (#311) on October 6, 2026... identical to a preliminary version of the present paper that was uploaded to ChatGPT on September 8, 2026"
LMAO get rekt
Kording Lab 🦖 retweeted
Congratulations to Francis, my friend and colleague! I am happy to see his bold vision and tenacity honored at the highest level. I first met Frances as an undergraduate and later took his class and TA’d for him as a graduate student @UWMadison. I’ve taught from his book, and now I’m proud to be his colleague. His enthusiasm has never waned, he is a timeless physicist. @uw_wipac
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2026 #NobelPrize in Physics to Francis Halzen “for decisive contributions to the IceCube Neutrino Observatory and the discovery of high-energy neutrinos of astrophysical origin.”
Kording Lab 🦖 retweeted

Mark Histed@HistedLabOct 5
United States!
United StatesConnected via United States App StoreLocation may be affected by a proxy or VPN.Account-level information, not a live location or per-post device.
Nobel Prize awarded for optogenetics.
Congrats to @KarlDeisseroth, Hegemann, and Nagel. The prize is well-deserved, for work that has been transformative.
a few quick thoughts 1/4 🧪#neuroscience
Kording Lab 🦖 retweeted
The difference between industry PR and rigorous academic discussion. Worth a read.
This is outrageous framing. Quite frankly, given the current tensions around AI and mathematics, this kind of announcement does not help.
After the recent Buckmaster/OpenAI dispute over scientific credit and provenance, the last thing we need is more promotional PR language that blurs the history of a research problem.
Meta presents its work by asking: “Can AI contribute when a problem is genuinely open and without an existing solution path?”
Seriously?! For the ellipsoid-fitting example, this is misleading and insulting. There was an established research programme, substantial rigorous progress, and by the time of their announcement, publicly available proofs of the exact threshold.
Let us be specific:
- In 2023, Antoine Maillard and Dmitriy Kunisky gave a statistical-physics derivation of the conjectured transition at n/d² = 1/4, using the replica method. Their analysis also predicted the geometry of the solutions and suggested directions for rigorous proofs. This was not a proof, but it was a detailed and successful theoretical picture, not an absence of a path.
arxiv.org/abs/2310.01169
- Afonso Bandeira and Antoine Maillard then rigorously established the sharp threshold for approximate fitting, using methods inspired by the statistical physics of disordered systems, using actually spin glass mathematical technics. Their preprint appeared in 2023 and was published in the Electronic Journal of Probability in 2025. Their Gaussian-equivalence framework provided a foundation for further work (including many of mine!). At this point, the "exact" fitting and removing the spectral restriction were the outstanding gaps, but these are technical problems, it was not about not discovering the threshold from scratch. arxiv.org/abs/2310.05787
- On 10 August 2026, Theodor Misiakiewicz and Garrett Wen posted a proof of the exact Gaussian threshold, explicitly closing those two gaps.
arxiv.org/abs/2608.10184
- On 12 August, Sofia de la Cerda, Aaron Potechin, Madhur Tulsiani and Jeff Xu posted another proof, establishing both sides of the transition up to a vanishing multiplicative factor. arxiv.org/abs/2608.12415
- On 27 August, Frederic Koehler and Youngtak Sohn posted a broader universality theorem that includes the Gaussian threshold. arxiv.org/abs/2608.27372
These were not researchers merely “on the verge” of solving the problem. THE PROOFS WERE ALREADY PUBLIC. Meta's announcement comes in October, and Section 3 of their paper begins:
“We use the groundbreaking approximate-fitting theorem of Bandeira and Maillard…”
Dear META: Those are your words. This is not simply a reference in the bibliography: your feasibility proof explicitly starts from their theorem.
How is that consistent with advertising this example through the suggestion that there was “no existing solution path”?
Yes, your social post mentions independent solutions, and your paper and blog identify the August results and describe your work as independently developed. That does not answer the objection to the framing. A generic acknowledgement of parallel work does not make clear that the exact threshold already had publicly available proofs before this announcement.
An independently developed AI-assisted proof, released after other proofs, should be presented as exactly that. Readers should not have to reconstruct the chronology to understand what is, and is not, new.
A new proof can contain valuable ideas. But a new proof and a newly solved problem are not the same claim. Nor does a problem being open when a project begins mean it is still open when the marketing campaign launches.
You say the aim is to “empower researchers”? Nothing more “empowering” than seeing years of collective research turned into the backdrop for a cheap marketing stunt.
Correct the announcement! Give the scientific history the same prominence as the product. Give Antoine, Afonso, Theo and all the other researchers involved the public credit they deserve.
Kording Lab 🦖 retweeted
A college president is suing faculty members for arguing she plagiarized (by presenting evidence that she did). One was the VP for Research, who filed a plagiarism report as part of his job.
It's a remarkable case that you'd think would cause outcry in the academic community.
Kording Lab 🦖 retweeted
How hard is it to get a grant these days?
NIH funding rates have fallen to their lowest in 30 years.
(data combines established and at-risk investigators, as defined by NIH).
Kording Lab 🦖 retweeted
There's a new imaging modality in town: functional ultrasound imaging. I went down a deep rabbit hole to understand how it works computationally. Read all about how it works physically and how *you* can improve it..
Kording Lab 🦖 retweeted
i was diagnosed with thyroid cancer many years ago purely by chance, because i had to get blood work for my US green card application (thank you, USCIS!). i was in my mid-30’s and was reasonably healthy (or so i believed.) this was shocking and totally unpredictable news to me. thanks to the amazing team of clinicians at NYU Langone, i successfully went through a total thyroidectomy followed by radioactive iodine therapy. but, it was truly the most uncertain and confusing period of my life.
this is when i first realized that no one can opt out of healthcare. being sick isn’t what you choose to or choose not to. it is something that unpredictably happens to all of us at some point for one reason or another. this is why it is a healthcare system that we collectively build and use to support each other at the society level. because it must support everyone, the complexity of creating, maintaining and improving this system is a Herculean effort that calls for all the help in the world.
today, i am announcing @OrtetAI together with my dear co-founders, @keunwoochoi, @HenriDwyer, @elmanmansimov, @causalclaudia and Jeff, to lend our support to improving the health of each and every one of us. Ortet’s goal is to create a technological foundation that will enable health systems to deliver predictably better care to each and every patient. this will only be possible by working closely with all stakeholders in the broader ecosystem, which is enabled in part by Ortet’s close partnership with Thoreau.
Ortet is taking the very first step of a long journey ahead, and at the end of this journey, i strongly believe we would be able to say that Ortet had contributed to building better, more predictable healthcare and thus to improving health of each and every one of us.
see ortet.ai/ for more!
Kording Lab 🦖 retweeted
“Don't think for a second that because you are an alarmist that you are doing a social good.”
This sentence is just devastating for so many intellectuals who need everybody to presume that they’re “the good people”
Thank goodness we have Jensen!
Kording Lab 🦖 retweeted
See you next week in Philadelphia! 🎉
In just a few days, researchers and educators from around the world will come together for three days focused entirely on scientific rigor.
We're excited for the talks, workshops, conversations, and games that happen when we bring our community together in the same room.
Which part of C4R26 are you most excited about?
See you at C4R26!
📅 September 28
📍 Philadelphia
#C4R26
Biology does not need models that just describe the world. It needs models that predict what happens when we intervene.
In @CellCellPress Focus on AI in Biology, we lay out how to build biomedical world models, from the data they need to how they should be trained and evaluated.
Kording Lab 🦖 retweeted
We’re hiring.
The Department of Bioengineering is seeking faculty at the Assistant, Associate and Full Professor levels across bioengineering as part of a multi-year hiring initiative.
Applications due Nov. 23, 2026.
Learn more + apply: be.engineering.upenn.edu/abo…
@PennEngineers

ALT Promotional graphic for an open faculty position in Penn Bioengineering. Large white text on a dark blue background reads, “OPEN FACULTY POSITION” and “Help Shape What’s Next in Bioengineering.” Two overlapping red-outlined diamond-shaped photos show Bioengineering researchers working in a laboratory and a faculty member standing in a lab. The Penn Engineering and Department of Bioengineering logos appear above a white “APPLY NOW” button.
Kording Lab 🦖 retweeted
NSF announces 3 additional topics as part of the NSF X-Labs initiative to pursue generational breakthrough science and technology efforts ift.tt/hKl1YtB



































