@LEADS_study

The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) is a NIH funded multi-site study focused on early-onset Alzheimer's Disease #LEADS

leads-study.org
Joined September 2019
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  • Following235
  • Followers1.2K
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Here's what you can see from the Apostolova Lab tomorrow, Monday July 17th! #AAIC23 #ENDALZ @ApostolovaLiana
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Replying to @BrianGordon81 @LEADS_study @NeuroimagingPIA
Here are the lovely faces of the wonderful faculty and trainees who are presenting the wealth of #LEADS data at #AAIC23 @_paigely @relajoie @TouroutoglouA @eloyan_ani @Ralyoyo @schonhaut @LEADS_study @RabLab_UCSF @DickersonLabMGH @DrMariaALZ
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Topics include but not limited to: 🧠 Early onset #AD: LEAD study 🧠 New hypothesis of AD pathogenesis 🧠 AD and gut microbiome 🧠 Artificial intelligence (#AI) in AD 🧠 Imaging biomarkers/ATN staging 🧠 CSF biomarkers 🧠 #DBS, #TMS and #tDCS in AD 🧠 Drug development
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A great pleasure to work with many field leaders and experts on this meaningful work- @MedscapeNeuro Decision Point: #Alzheimers & related #dementia section. 🫴 Pls check our expert video commentaries on guidelines & practice recommendation. More to come! decisionpoint.medscape.com/n…
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Here is a video of one of my favorite LEADS couples - Mary and Peggy! Mary is one of my bravest patients. She developed problems with memory in her late 50s. Such a heartwarming interview. Click on the link: youtube.com/watch?v=RtvXb3QB…
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We compared 10 different p-tau assays for detection of amyloid pathology (important for anti-amyloid immunotherapies) and progression to AD dementia (important for prognosis). The results are clear; p-tau217 is the best p-tau biomarker in symptomatic AD, independent of method.
Brain@Brain187822 Apr 2023
Janelidze et al. test 10 plasma phospho-tau assays head-to-head for their ability to detect abnormal brain amyloid-β status and predict future progression to Alzheimer's dementia in individuals with mild cognitive impairment. bit.ly/3opUmfv
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Great presentation on @LEADS_study at @adpdnet by @ApostolovaLiana of @iadrc_iu @IUMedSchool @NeurosciStark! #ADPD2023
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Call for papers for the 2023 DADM special issues: - IADLs and Neuropsychiatric Symptoms in ADRD - Sensory Changes in ADRD - Bayesian Methods that Address the Questions We Actually Ask The deadline to submit your work is August 15, 2023 @alzdemjournals @WileyNeuro .
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Honored to have @ApostolovaLiana as my mentor! She is an exceptional leader and a true source of inspiration and support for everyone in our lab. I am so grateful to be her trainee and to have been a part of this nomination process. Congratulations again!!
Liana Apostolova, MD, MSc, FAAN@ApostolovaLiana20 Feb 2023
I feel incredibly honored to be the 2023 IUPUI Bynum Faculty Mentor Award recipient! I have the best lab ever full of bright young scientists who make my job easy and pleasurable. Thank you, Apostolova Lab trainees, for the nomination!
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Congratulations to @nemes_sara (Apostolova Lab), @NeuroJenya (Saykin and Sporns Labs) and Rachael Deardorff (Saykin Lab) for becoming the recipients of the 2023 John West Scholar Awards from the @iadrc_iu!
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Submitted! Crossing my fingers this is how everyone will see me (and my fellow lab mates) in mid-July this year. Go @LEADS_study!!! #AAIC2023
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#DADM Editor-in-Chief @ApostolovaLiana of @IndianaUniv is principal investigator of the @LEADS_study, which aims to improve our understanding of, and launch clinical trials in, younger-onset Alzheimer’s. #WomenInScience #NeuroTwitter
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The first Apostolova Lab paper of 2023, check it out! "APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD" doi.org/10.1002/alz.12955 @ApostolovaLiana #ENDALZ #ApostolovaLab
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Our lab and @RabLab_UCSF presented a whirlwind of imaging and fluid biomarker results in @LEADS_Study EOAD at #HAI2023. Stay tuned for #ADPD and #AAIC where we will present a great deal more. Go team LEADS!
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It was great to see work from @abc_ds_ @LEADS_study and DIAN in one session at @HAIconference. Matt Zammit did a fantastic job presenting a first look at longitudinal tau PET in individuals with Down Syndrome.
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BIG NEWS! Over the weekend, the Indianapolis #Walk2EndAlz reached $1 million for the first time ever! 🎉 Shoutout to the @LEADS_study & @iadrc_iu teams for bringing us across the finish line - and thank you to EVERYONE who contributed! This is YOUR moment!
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***IMPORTANT UPDATE*** Please see the extended deadlines for the modifiable risk factors, SDOH, and data harmonization special issues for DADM. Please share widely. TX!
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Our new article in @ScienceTM is out! We provide evidence that the connectivity properties of the human brain provide a framework for tau spreading in different clinical variants of AD science.org/doi/10.1126/scit…

Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical...

The diversity of Alzheimer’s disease phenotypes is influenced by the connectivity patterns of the brain, which serve as tau propagation pathways.

science.org
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Key Point 6 from the article Atypical #Alzheimer Disease Variants by Drs. Angelina J. Polsinelli and Liana G. Apostolova (@ApostolovaLiana), which is open to all at continpub.com/AtypicalAD. #dementia #MedEd #NeuroTwitter
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Key Point 5 from the article Atypical #Alzheimer Disease Variants by Drs. Angelina J. Polsinelli and Liana G. Apostolova (@ApostolovaLiana), which is open to all at continpub.com/AtypicalAD. #dementia #MedEd #NeuroTwitter
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