@LMB_Library
 Cambridge
Joined March 2012
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November Focus: Men's Health. Find your next read at the Library end of the @MRC_LMB atrium.
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NEW #LMBPublications FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology ift.tt/JKO2VP4

FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology - PubMed

Immunoglobulin G (IgG) is traditionally recognized as a plasma protein that neutralizes antigens for immune defense. However, our research demonstrates that IgG predominantly accumulates in adipose...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Structural insights into a DNA polymerase reading the xeno nucleic acid HNA ift.tt/QT6GeDU

Structural insights into a DNA polymerase reading the xeno nucleic acid HNA - PubMed

Xeno nucleic acids (XNAs) are unnatural analogues of the natural nucleic acids in which the canonical ribose or deoxyribose rings are replaced with alternative sugars, congener structures or even...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Efficient circular RNA synthesis for potent rolling circle translation ift.tt/0I4oQ2b

Efficient circular RNA synthesis for potent rolling circle translation - PubMed

Circular RNA (circRNA) is a candidate for next-generation messenger RNA therapeutics owing to its remarkable stability. Here we describe trans-splicing-based methods for the synthesis of circRNAs...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Circadian Control of Protein Synthesis ift.tt/yn31laH

Circadian Control of Protein Synthesis - PubMed

Daily rhythms in the rate and specificity of protein synthesis occur in most mammalian cells through an interaction between cell-autonomous circadian regulation and daily cycles of systemic cues....

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Modelling human brain development and disease with organoids ift.tt/JDYv3ef

Modelling human brain development and disease with organoids - PubMed

Organoids are systems derived from pluripotent stem cells at the interface between traditional monolayer cultures and in vivo animal models. The structural and functional characteristics of organoids...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription ift.tt/7DyA4x5

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early...

Control of RNA polymerase II (RNA Pol II) through ubiquitylation is essential for the DNA-damage response. Here, we reveal a distinct ubiquitylation pathway in human cells, mediated by CRL3ARMC5,...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus ift.tt/iNsFIGh

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus - PubMed

Type IV pili (T4Ps) are abundant in many bacterial and archaeal species, where they play important roles in both surface sensing and twitching motility, with implications for adhesion, biofilm...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications A framework for neural organoids, assembloids and transplantation studies ift.tt/1nq63FL

A framework for neural organoids, assembloids and transplantation studies - PubMed

As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications A finger that gets in the way: When binding isn't just about the bound state ift.tt/vSIMtpn

A finger that gets in the way: When binding isn't just about the bound state - PubMed

In this issue of Structure, Viennet et al.1 report a study characterizing the DNA binding by a three-zinc-finger fragment from the transcription factor BCL11A, with the unusual feature that an...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications A cryo-electron tomography study of ciliary rootlet organization ift.tt/i6aXfUR

A cryo-electron tomography study of ciliary rootlet organization - PubMed

Ciliary rootlets are striated bundles of filaments that connect the base of cilia to internal cellular structures. Rootlets are critical for the sensory and motile functions of cilia. However, the...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Structure and methyl-lysine binding selectivity of the HUSH complex subunit MPP8 ift.tt/gkBzAjE

Structure and Methyl-lysine Binding Selectivity of the HUSH Complex Subunit MPP8 - PubMed

The Human Silencing Hub (HUSH) guards the genome from the pathogenic effects of retroelement expression. Composed of MPP8, TASOR, and Periphilin-1, HUSH recognizes actively transcribed retrotranspo...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications LXR regulation of adipose tissue inflammation during obesity is associated with dysregulated macrophage function ift.tt/TH2oLcB

LXR regulation of adipose tissue inflammation during obesity is associated with dysregulated...

Our study highlights distinct roles for each LXR isoform in AT inflammation regulation, with LXRβ being crucial for maintaining the anti- and proinflammatory balance in ATMs. Thus, LXRβ holds...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Improving macromolecular structure refinement with metal-coordination restraints ift.tt/S1MOV5Q

Improving macromolecular structure refinement with metal-coordination restraints - PubMed

Metals are essential components for the structure and function of many proteins. However, accurate modelling of their coordination environments remains a challenge due to the complexity and diversity...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications RNA-Puzzles Round V: blind predictions of 23 RNA structures ift.tt/tWsxOzT

RNA-Puzzles Round V: blind predictions of 23 RNA structures - PubMed

RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predic...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Identification of a factor that accelerates substrate release from the signal recognition particle ift.tt/TyCYGdh

Identification of a factor that accelerates substrate release from the signal recognition particle...

The eukaryotic signal recognition particle (SRP) cotranslationally recognizes the first hydrophobic segment of nascent secretory and membrane proteins and delivers them to a receptor at the endopla...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Making PI3K superfamily enzymes run faster ift.tt/1stmiTQ

Making PI3K superfamily enzymes run faster - PubMed

The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM, ATR, DNA-PKcs, SMG1 and TRRAP)...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge ift.tt/edjzpqr

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend...

A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes (ICs). How such...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications New players and targets in mannose 6-phosphate-dependent lysosomal sorting ift.tt/xZGVgCS

New players and targets in mannose 6-phosphate-dependent lysosomal sorting - PubMed

The Golgi apparatus serves multiple crucial roles in the cell. These roles include the addition and subsequent modification of glycans, not only to newly-made proteins arriving from the endoplasmic...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications A physical model for M1-mediated influenza A virus assembly ift.tt/H5C2rTN

A physical model for M1-mediated influenza A virus assembly - PubMed

Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a protru...

pubmed.ncbi.nlm.nih.gov
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NEW #LMBPublications Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease ift.tt/f4EKrsq

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease - PubMed

The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates with extracellular...

pubmed.ncbi.nlm.nih.gov
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