@LSAjournal

#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By @EMBOPress, @RockUPress and @CSHLPress.

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life-science-alliance.org/
Joined September 2017
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SARS-CoV-2 Nucleocapsid promotes recruitment of IRF & AP-1 transcription factors 🧬, RNA polymerase II, and eEF1A1 to pro-inflammatory gene promoters, revealing a previously unrecognized nuclear role for eEF1A1 @IGBMC👇 hubs.la/Q04BfHf20
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Take a look at this recently published paper in LSA: Esc2 and Rad57 contribute to RNA polymerase II distribution at highly transcribed genes👇 hubs.la/Q04B5ClC0
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Gut microbiota and their metabolites shape MASLD progression by modulating intestinal barrier integrity, inflammation, metabolism, and liver signaling. @IIMCB_Poland hubs.la/Q04B5zcN0
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More data ≠ more understanding. Commentary in Life Science Alliance maps where biomedical research breaks down along the data-information-knowledge-wisdom hierarchy & why scientists & AI alike must stay open to being wrong. #DIKW #AI @dokhlab @MedicineUVA hubs.la/Q04BH-9v0
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PK2 is essential for Plasmodium berghei transmission. Its depletion impairs ookinete motility, disrupts microneme organisation, blocks oocyst and sporozoite development, and alters invasion-related phosphorylation. @ReviewCommons hubs.la/Q04zPBg40
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The study shows that interpretation of H3K4me3 is essential for translating chromatin information into the developmental decisions that establish embryonic patterning in Arabidopsis. life-science-alliance.org/co…
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Gierse et al. show that ROCK1's PHC1 domain is recruited to elevated cortical Rho activity, that it cooperates with the Rho-binding domain (RBD), and that it participates in cell contraction signaling. hubs.la/Q04zNmw70
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📢 Autolysosomal enhancer GHF201 attenuates pathophysiology in a mucopolysaccharidosis-I mouse model   @Hadassah 👇 hubs.la/Q04zNl5x0
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This study links macrophage dysferlin to Ca²⁺-dependent STAT1-associated inflammatory responses and impaired myogenic differentiation in cellular models. @YamaguchiU_koho hubs.la/Q04zJQRD0
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Allele-specific profiling of ribosome-associated mRNAs reveals widespread cis-regulatory effects on translation and shows that 80S monosome analysis improves detection sensitivity. @alberto_inga @aromanel hubs.la/Q04zJPcw0
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Haplotype-resolved genome of a dry-preservable cell line reveals chromosome evolution and DNA damage @UTokyo_News_en hubs.la/Q04zJqYZ0
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SARS-CoV-2 Nucleocapsid promotes recruitment of IRF and AP-1 transcription factors, RNA polymerase II, and the elongation factor eEF1A1 to promoters of pro-inflammatory genes, revealing a previously unrecognized nuclear role for eEF1A1. @IGBMC hubs.la/Q04BfGxD0
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“We were impressed by both the professionalism of the team and the journal’s breadth and depth across various fields of the life sciences.”—Diana P. Bratu. Publish in LSA, a network that works for you. hubs.la/Q04xwNxV0
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Read Dr. Bratu and colleagues’ article in LSA today, “Bruno 1 remodels P-bodies to protect select mRNAs during the early ER stress response” life-science-alliance.org/co…

Bruno 1 remodels P-bodies to protect select mRNAs during the early ER stress response

P-bodies are cytoplasmic membraneless organelles involved in mRNA storage, yet their role in cellular stress responses remains unresolved. Here, we demonstrate that P-bodies are remodeled during the...

life-science-alliance.org
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Recombination-related factors are linked to gene-body Pol II occupancy and transcription-associated chromatin states at highly active genes in yeast. hubs.la/Q04B5Bcd0
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The review highlights how gut microbiota alterations and microbial metabolites drive MASLD progression, influencing metabolism, inflammation, and gut barrier integrity. @IIMCB_Poland hubs.la/Q04B5z3L0
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PK2 is essential for Plasmodium berghei transmission. Its depletion impairs ookinete motility, disrupts microneme organisation, blocks sporozoite production, and alters invasion-related phosphorylation. @ReviewCommons hubs.la/Q04zPx950
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A new piece of the Rho-ROCK signaling puzzle. This study reveals that the C-terminal PHC1 domain of ROCK1 helps recruit the kinase to active Rho signaling zones and contributes to transmitting Rho activity into cell contraction. hubs.la/Q04zNlMl0
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This work demonstrates that the autolysosomal enhancer GHF201 attenuates pathophysiology in an MPS-I mouse model @Hadassah hubs.la/Q04zJR9v0
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Macrophage dysferlin regulates Ca²⁺-dependent STAT1-associated inflammatory responses and influences myogenic differentiation in cellular models. @YamaguchiU_koho hubs.la/Q04zJQvp0
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