@LabHalic

Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio

 Memphis, USA
stjude.org/directory/h/mario-halic.html
Joined August 2019
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  • Following265
  • Followers703
8Media
Cool stuff from the Ansari Lab out in Nature Cell Bio: rdcu.be/fx0kn @StJudeResearch
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nature.com/articles/s41592-0… Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale" rdcu.be/eS2ps An advance in experimental throughput and sensitivity that revealed unexpected results!

Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale

Nature Methods - Parallelized single-molecule fluorescence and single-molecule FRET experiments enable quantitative biophysics investigations of molecular function from multiple samples in a single...

nature.com
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Researchers have mapped 117 kinases capable of phosphorylating the RNA polymerase II tail, revealing modifications at previously disregarded positions beyond amino acids two and five. This discovery expands our understanding of gene transcription control. ow.ly/crFR50Xo1en

Kinase atlas uncovers hidden layers of cell signaling regulation

See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.

stjude.org
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Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H nature.com/articles/s41422-0… @StJudeStructBio @StJudeResearch

Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H

Cell Research - Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H

nature.com
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Scientists used cryo-EM to capture 13 distinct structures of the chromatin remodeler SNF2H in action. This research provides a complete view of nucleosome sliding, a key process in gene regulation. ow.ly/mhv150VtUoH

Chromatin remodeling captured in comprehensive structural study

See how St. Jude scientists used cryo-EM to uncover the structural mechanisms of chromatin remodeling enzyme SNF2H, advancing gene regulation research.

stjude.org
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Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/S0092… Explore this amazing resource here: yslproteomics.shinyapps.io/t…
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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G
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A preprint from the lab led by graduate student Dana R Kennedy. doi.org/10.1101/2024.10.25.6… Over 20 years ago, the Eissenberg lab showed that phosphorylation of HP1 is important for its silencing function. Why? Key observations from our study in fission yeast:
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We have exciting news to share! Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec. Welcome to @stjuderesearch, Abhay!
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Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF
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Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2! Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution nature.com/articles/s41594-0…

Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily

Nature Structural & Molecular Biology - This study presents the cryo-electron microscopy structure of Fanzor2, showcasing its unique structural elements and nucleic acid interaction sites. A...

nature.com
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St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch ow.ly/gQbN50TAASu
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Happy to share our latest work from the @kellogg_liz lab, in collaboration with the Protein Technologies Center at St. Jude, where we describe the structure of Fanzor2. Special thanks to my co-authors, Zuhaib Qayyum and Ajay Tanwar. nature.com/articles/s41594-0…

Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily

Nature Structural & Molecular Biology - This study presents the cryo-electron microscopy structure of Fanzor2, showcasing its unique structural elements and nucleic acid interaction sites. A...

nature.com
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Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/S0092…

Pervasive mislocalization of pathogenic coding variants underlying human disorders

Pathogenic missense variation can affect protein function in many ways, but the role of protein mislocalization has not been systematically assessed. By characterizing the localization of 3,400...

cell.com
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We are thrilled to welcome the incomparable Yiorgo Skiniotis and his lab! Yiorgo will also lead the new Center of Excellence for Structural Cell Biology, to advance cryoET and other cutting-edge approaches @StJudeResearch, paving the way for new, exciting biological insights!
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Building on the work of Richard and Chris, here is our latest work showcasing the potential of the 100 keV #Tundra microscope with the Ceta F and Falcon C. We achieved high-resolution structures for a variety of protein complexes🧵.🔬#100keV #CryoEM. Movie by @lingboyu
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Our work on human urate transporter is out @cell_res. @YaxinDai single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio nature.com/articles/s41422-0…

Transport mechanism and structural pharmacology of human urate transporter URAT1

Cell Research - Transport mechanism and structural pharmacology of human urate transporter URAT1

nature.com
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🚨 New Research Alert! 🚨 Excited to share our latest paper on PHF6's role in linking H3K14 acetylation, #SWISNF, and #RNApolymerase complexes. Now live in @NatureComms! 🎉 Big congrats to the first author, @priya1012007, and all co-authors! 👏 nature.com/articles/s41467-0…

PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression

Nature Communications - Here, the authors identify PHF6 as a dependency in SMARCB1-deficient rhabdoid cancers. Mechanistically, this study suggests a regulatory role for PHF6 in recruiting SWI/SNF...

nature.com
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It is great fun to collaborate with @mjafreeman, the leading expert in the field. @lu_fangfang and @HongtuZhao worked together to reveal the structures of the ADAM17 sheddase complex and showed how iRhom2 restrains ADAM17 protease activity. sciencedirect.com/science/ar…
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Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/ nature.com/articles/s41586-0…

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF

Nature - DCAF5 has a quality-control function for SWI/SNF complexes and promotes the degradation of incompletely assembled SWI/SNF complexes in the absence of SMARCB1.

nature.com
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