Poltorak Lab (@LabPoltorak) header
Poltorak Lab (@LabPoltorak) profile picture

Poltorak Lab

@LabPoltorak

Twitter for Alexander Poltorak's Lab at Tufts University School of Medicine

Joined October 2019
  • Tweets63
  • Following112
  • Followers196
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Photo by Poltorak Lab (@LabPoltorak)Photo by Poltorak Lab (@LabPoltorak)Photo by Poltorak Lab (@LabPoltorak)Photo by Poltorak Lab (@LabPoltorak)
Poltorak Lab retweeted
Ivan Zanoni (@Lo_Zanzi) profile picture
Ivan Zanoni
@Lo_Zanzi22 Jun 2025
#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show @SciImmunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release science.org/doi/10.1126/scii…
TNF switches homeostatic efferocytosis to lytic caspase-8–dependent pyroptosis and IL-1β maturation

TNF switches homeostatic efferocytosis to lytic caspase-8–dependent pyroptosis and IL-1β maturation

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production.

science.org
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Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production @SciImmunology @LabPoltorak science.org/doi/10.1126/scii…
Image from Waggoner Lab (@LabWaggoner)
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Scientists have found that tumor necrosis factor can switch macrophage #efferocytosis from immunologically silent to pro-inflammatory during #sepsis and systemic inflammation. @LabPoltorak Learn more in Science #Immunology: scim.ag/45Yvj6Y
Image from Science Immunology (@SciImmunology)
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Poltorak Lab retweeted
Abe Bayer, PhD (@AbeBayer) profile picture
Abe Bayer, PhD@AbeBayer2 Jun 2025
Excited to have contributed to this paper!!! Read here how STING regulates microglia in aging. Congrats to @kate_sulka and the whole team!!! @CellReports sciencedirect.com/science/ar…
Image from Abe Bayer, PhD (@AbeBayer)
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Poltorak Lab retweeted
Abe Bayer, PhD (@AbeBayer) profile picture
Abe Bayer, PhD@AbeBayer24 Feb 2025
Have you seen our papers on T-cell Myd88 in HF and cancer (links in 🧵) and wondered what the mechanism at the TCR was? We now outline a novel molecular role for MyD88 acting downstream of the TCR and regulating activation / cell death, out in @J_Immunol academic.oup.com/jimmunol/ad…

MyD88 determines T cell fate through BCAP-PI3K signaling

Abstract. The life cycle of effector T cells is determined by signals downstream of the T cell receptor (TCR) that induce activation and proinflammatory ac

academic.oup.com
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Poltorak Lab retweeted
Abe Bayer, PhD (@AbeBayer) profile picture
Abe Bayer, PhD@AbeBayer24 Feb 2025
Thank you to @LabPoltorak @ZoieMagri @PilarAlcaidePhD for making this study possible. Previous papers on T-Myd88 at @CircRes (ahajournals.org/doi/10.1161/…) and @AJPathology (sciencedirect.com/science/ar…)
T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation |...

T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation |...

BACKGROUND: Cardiac inflammation in heart failure is characterized by the presence of damage-associated molecular patterns, myeloid cells, and T cells. Cardiac damage-associated molecular patterns...

ahajournals.org
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After reporting a role for T cell MyD88 during cardiac adaptation to stress @CircRes & in melanoma @AJPathology, we now decipher a molecular mechanism👇. Thank U @J_Immunol @AbeBayer @LabPoltorak @ZoieMagri @TuftsMedSchool academic.oup.com/jimmunol/ad…

MyD88 determines T cell fate through BCAP-PI3K signaling

Abstract. The life cycle of effector T cells is determined by signals downstream of the T cell receptor (TCR) that induce activation and proinflammatory ac

academic.oup.com
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Poltorak Lab retweeted
Ivan Zanoni (@Lo_Zanzi) profile picture
Ivan Zanoni
@Lo_Zanzi4 Nov 2024
#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OA…
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An exciting Halloween week for the Poltorak lab! Two successful PhD defenses in one week! Congrats David Jetton and @ZoieMagri ! Big thank you to outside examiners @MichelleKellih3 and @Lo_Zanzi for fabulous discussions! @TuftsGSBS
Image from Poltorak Lab (@LabPoltorak)
Image from Poltorak Lab (@LabPoltorak)
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It was an exciting August in the Poltorak Lab! #Twisters @TuftsGSBS @ZoieMagri @CellReports
Image from Poltorak Lab (@LabPoltorak)
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We found CD14 can switch Fas signaling from pro-death to pro-inflammatory! Check out our recent work in @CellReports to learn more. Congrats to first author @ZoieMagri! cell.com/cell-reports/fullte…
CD14 is a decision-maker between Fas-mediated death and inflammation

CD14 is a decision-maker between Fas-mediated death and inflammation

Activation of the Fas receptor can be pro-death or pro-inflammatory, but little is known about the switch between outcomes. Magri et al. demonstrate that TLR adaptor CD14 can mediate this switch...

cell.com
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How does RIPK1 drive activation of caspase 8 in Yersinia infection?? Read our latest paper in @CellReports to find out! Congrats to first author David Jetton @TuftsGSBS cell.com/cell-reports/fullte…
Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

The role of specific autophosphorylations driving RIPK1-dependent death is unclear. Jetton et al. demonstrate that autophosphorylation of RIPK1 T169 is required to initiate caspase-8-dependent...

cell.com
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Poltorak Lab retweeted
preLights (@preLights) profile picture
preLights@preLights9 Apr 2024
Neurons repurpose death complex components to induce an anti-viral response during Zika virus infection. In her first preLight, @ZoieMagri covers recent work from the lab of @AndrewOberst. #preprint #preLight 👉 prelights.biologists.com/hig…
Detection of MLKL protein by immunofluorescent staining and analysis in untransduced or AAV6-MND-MLKL transduced Mox2cre+Ripk3-2xFVLSL neurons 24 hours after B/B treatment (Representative of 2 separate experiments)

ALT Detection of MLKL protein by immunofluorescent staining and analysis in untransduced or AAV6-MND-MLKL transduced Mox2cre+Ripk3-2xFVLSL neurons 24 hours after B/B treatment (Representative of 2 separate experiments)

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A recent preprint from the lab of @AndrewOberst demonstrates that neurons can repurpose death complex components to induce an anti-viral response to Zika! I’ve highlighted their work in my latest preLights post. Check it out! prelights.biologists.com/hig…
RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons - preLights

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons - preLights

Neurons repurpose death complex components to induce an anti-viral response during Zika virus infection.

prelights.biologists.com
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This symposium on #celldeath and survival will discuss exciting developments in this field including inflamed tissues and non-canonical #molecularpathways. Register for #Pathobiology2024 to attend this session! bit.ly/3TndnfK @Penn @TuftsUniversity @NotreDame @YaleMed
Image from American Society for Investigative Pathobiology (@ASIPath)
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Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave bit.ly/3ZEKoWc
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Check out this piece by one of our PhD students @ZoieMagri in the @ConversationUS ! Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave theconversation.com/cell-dea…
Cell death is essential to your health − an immunologist explains when cells decide to die with a...

Cell death is essential to your health − an immunologist explains when cells decide to die with a...

Your cells die to keep you alive. Cell death does everything from fighting cancer cells and pathogens to forming your fingers and toes.

theconversation.com
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➡️Join us at the next BCDI meeting on Monday Oct 2nd at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions with @chendi on inducing apoptosis in NSCLC and @nabel on identifying novel therapy targets in thymic epithelial tumors. More info: BostonCellDeath.org
Image from Kristopher Sarosiek (@CellDeathLab)
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Intriguingly, & consistent with the earlier work of @LabPoltorak (pnas.org/doi/10.1073/pnas.18…), Jenna found that unlike in mouse macrophages, WT Yersinia fails to induce cell death in human IECs & macrophages, indicating that human cells are unable to undergo YopJ-mediated death. 4/n
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection | PNAS

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection | PNAS

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (T...

pnas.org
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➡️Join us at the next BCDI meeting on Monday Sept 11th at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions led by @TheLeeLab on cell death in response to transcription blockade and @OylerYanivLab on cell death in infections. More info: BostonCellDeath.org
Image from Kristopher Sarosiek (@CellDeathLab)
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