TalbotLab retweeted
Significant funding cuts for ZFIN are causing staff reductions in 2021. We will be losing three software developers, our systems administrator and administrative assistant. Additionally, two curators will reduce to half time. Further cuts may be needed in the next few years. 1/3
TalbotLab retweeted
Muscles form at first in zebrafish mutants, then degenerate during development, actually breaking apart @LabTalbot. mylpf needed for maintaining myofiber integrity but not formation or growth 7/10
TalbotLab retweeted
@LabTalbot showed mylpf exclusively expressed in fast-twitch muscles. Zebrafish mutants had lower myosin activity => paralyzed pectoral fins (aka fish limbs). Muscle membrane structure disorganized too, but only among fast-twitch fibers 6/10
TalbotLab retweeted
Preprint for our newest #RareDisease gene discovery w/@mikebamshad @UWCMG @LabTalbot @debnick. This has been the works for almost SIX years (glad we shared our initial cases on @MyGene2 years ago!) 1/10
Mutations in MYLPF cause a novel segmental amyoplasia that manifests as distal arthrogryposis biorxiv.org/cgi/content/shor… #bioRxiv
It's been a long journey- but I'm proud of what we learned and the story we are now able to tell. And I'm glad you found opportunities to share the human findings as they came in.