The Zhu lab studies the moon/tide-related 12h ultradian clock; xbp1, proteostasis, epigenetic, metabolism, aging, stress response are the key words. @AgingPitt
Aging Institute, Divison of Endocrinolog…
Joined June 2018
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It is a great pleasure to share our most recent work on ‘rejuvenating’ nuclear speckles to ameliorate proteinopaties such as Tauopathy and retinitis pigmentosa. It is my first publication that is not related to biological rhythms and I am very excited to
nature.com/articles/s41467-0…
Bokai Zhu lab retweeted
The wildest part of the Nobel drama is that the least-discussed guy left out, Zhuo-Hua Pan, has a better claim on the tech than Boyden and he’s the only one with any shot of turning opto into a real therapy….he just wasn’t at a prestigious institution
statnews.com/2016/09/01/opto…
What if a tiny nuclear structure helps determine whether neurons survive or degenerate?
Our new Trends in Neurosciences review explores how nuclear speckles—dynamic nuclear condensates once thought to be passive splicing hubs—coordinate RNA metabolism, stress responses,
and proteostasis, and how their dysfunction contributes to ALS/FTD and tauopathies.
Great collaboration with Xu Chen, and thanks to editor Moran Furman for his guidance.
authors.elsevier.com/a/1mjZR…
#Neurodegeneration #RNAbiology #BiomolecularCondensates #Proteostasis #ALS #Tauopathy
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day! link.springer.com/article/10…
I am so sad to hear the passing of Dr. Bert O’Malley today. He has been a great mentor for me and has always been my inspiration for pursuing science. The world has lost a great scientist and mentor today.
Bokai Zhu lab retweeted
Sadden to hear the passing of Dr. Bert O’Malley, the father of molecular endocrinology, a long-time mentor, and friend.
Pyrvinium as a nuclear speckle rejuvenator independently validated in a new study.
SWING domains prime chromatin for nuclear body–mediated gene regulation biorxiv.org/content/10.1101/…
Glad to see this paper finally out. It was a fascinating story when it first came out as a preprint a few years back.
Collective homeostasis of condensation-prone proteins via their mRNAs: nature.com/articles/s41586-0…
Bokai Zhu lab retweeted
Collective homeostasis of condensation-prone proteins via their mRNAs: nature.com/articles/s41586-0…
Bokai Zhu lab retweeted
#Postdoc opportunity at Columbia U. in New York!
We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU!
hhmi.wd1.myworkdayjobs.com/E…
GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells | Nature Communications nature.com/articles/s41467-0…
Bokai Zhu lab retweeted
LYVAC/PDZD8 is a lysosomal vacuolator | Science science.org/doi/10.1126/scie…
Bokai Zhu lab retweeted
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵
rdcu.be/eBwPJ
Bokai Zhu lab retweeted
A multichaperone condensate enhances protein folding in the endoplasmic reticulum: nature.com/articles/s41556-0…
Bokai Zhu lab retweeted
Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia today.ucsd.edu/story/antipar…
Bokai Zhu lab retweeted
Excited to see the work by @Yale_INP students Suzhou Yang @Denethi_W w/ collabs @YaleNeuro iPSC core @jdpereira @ArabTanina and @MayoClinicNeuro @gendron_tania @NeuroUdit on #C9orf72 #ALS & #FTD finally out in @NatureNeuro! @WuTsaiYale @KavliAtYale nature.com/articles/s41593-0…
Nuclear speckle rejuvenation “next frontier” for treating neurodegeneration, via @EurekAlert! eurekalert.org/news-releases…
