Layth Abdulrasool

A patient presented to the emergency room with nausea, vomiting, abdominal pain, decreased urinary output, and rhabdomyolysis. History of heavy drinking and cocaine abuse. Below is his renal Bx @podocytes @koony84 @kelsmith_path @AlpersCharles @UWNephrology. DDx?

A patient presented for evaluation of worsening chronic kidney disease in the setting of newly developed proteinuria with lifelong, poorly controlled hypertension. While not seen in the LM material, the diagnostic findings were seen in the material submitted for IF and EM.

Classic example with unusual finding, minimal change disease with a glomerular thrombus and congestion with red blood cells raises the possibility of a hypercoagulable state (e.g. renal vein thrombosis, emboli) related to nephrotic syndrome @podocytes @koony84 @kelsmith_path.

Exuberant epithelial cells response to AL type amyloid with multinucleated giant cells reaction and mitosis. Possible crescentic amyloidosis, any thoughts?@JZRenalPath @ChangUCanSpare @UNCKidney @podocytes @kelsmith_path @koony84 @AlpersCharles @sam_albadri @ErikaBracamo316

Perfect timing with the #KidneyWK breakthrough discovery "anti-nephrin autoantibodies and podocytes dusting with IgG in MCD". It will be a great practice to follow and ensure a better patient outcome @podocytes @koony84 @UWNephrology @kelsmith_path @AlpersCharles @AstridWeins.

And here are the EM findings

Monoclonal kappa light chain deposition disease in a 6 year-old transplanted kidney, recently presented with elevated creatinine and proteinuria @uwpathology @UWNephrology @AlpersCharles @podocytes @koony84 @kelsmith_path

76 years old female clinically with marked elevated lambda light chains. The Bx showed rare atypical almost crystalline appearing casts that demonstrated lambda chain staining bias on salvage IF @podocytes @kelly_mcclymont @koony84 @AlpersCharles @uwpathology @UWNephrology.