prof at UC Santa Barbara. https://xitter.cf/t.co/nj3RtLGy3K Neuroscience, neuroengineering, and computation. Optics, imaging, circuitry. Sharing notes at https://xitter.cf/t.co/NhYOb5zygg

Santa Barbara, CA
Joined July 2011
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Spencer LaVere Smith@Labrigger19 Jun 2025
It seems like magic! Also works for increasing the phase range of adaptive optics! Check out this video if you want to be walked through the preprint. youtube.com/watch?v=qO1nenu6… 2/2
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Spencer LaVere Smith@Labrigger19 Jun 2025
NEW PREPRINT: For 2-photon imaging (or any laser scanning), fast scanning often shrinks the field-of-view and/or decreases resolution. Che-Hang Yu found a bunch of ways to increase the field-of-view, with no trade-offs in speed or resolution. 1/2 biorxiv.org/content/10.1101/…
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Spencer LaVere Smith@Labrigger19 Jun 2025
Thanks, Bruno! And if anyone wants to learn more about the optics, they might have fun with this video: youtube.com/watch?v=qO1nenu6…
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Spencer LaVere Smith retweeted
Fantastic work (as always) from Che-Hang Yu and colleagues in Spencer Smith's lab @Labrigger. Neat method to increase scan speed and/or FOV in 2p microscopy. Commercially available from @pacificoptica . I'd love to build this for a client at some point! biorxiv.org/content/10.1101/…
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Spencer LaVere Smith retweeted
Beautifull! Nisam + Cousa (>3 mm x > 3mm) by Che-Hang Yu et al.
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Spencer LaVere Smith@Labrigger17 Jun 2025
This is actually fun. Try it! Your preprint -> AI-generated fake podcast -> video with actual human commentary -- It's remarkably effective! Awesome optics work to unlock big-and-fast in vivo two-photon calcium imaging, by Che-Hang Yu. youtube.com/watch?v=qO1nenu6…
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Spencer LaVere Smith@Labrigger2 Feb 2025
I wrote to my representatives again. Maybe at this point I should just let them subscribe to my newsletter.
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Spencer LaVere Smith@Labrigger1 Feb 2025
I gave some $ to aclu.org
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Spencer LaVere Smith retweeted
Announcing for the first time: the largest, fastest scanning multiphoton imaging pacificoptica.com/ventana/ #photonicswest #spie
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Spencer LaVere Smith retweeted
Huge field of view with a scan engine pacificoptica.com/ventana/
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Spencer LaVere Smith retweeted
The Ventana SL and Ventana TL are now available. pacificoptica.com/ventana/ This is a new standard in scan engine optics. Nothing else comes close. These optics enable diffraction-limited imaging over a huge field-of-view. They're easy to integrate into your systems.
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Spencer LaVere Smith@Labrigger17 Nov 2024
If you want another level, try our slack-like Nemonic group. Contact me if you want access. 2p.ece.ucsb.edu/ and/or try this link: 2p.ece.ucsb.edu/signup_user_…
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Spencer LaVere Smith@Labrigger17 Nov 2024
I'm on social media to share with technical communities in neuro, optics, computation, ML, etc. I don't need a free-for-all platform with the potential to reach millions. Mastodon is a good fit for me. (2/3)
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Spencer LaVere Smith@Labrigger17 Nov 2024
I have new posts and whatnot here: neuromatch.social/@sls I'm on mastodon because it's simple, clean, open, and a community. It's not perfect, but there's no profit-driven algorithm. Bluesky is nice from what I hear, but it could easily run into the same issues. (1/3)
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Spencer LaVere Smith@Labrigger30 Oct 2024
Replying to @BoninLab
I'll try again right now.
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Spencer LaVere Smith@Labrigger29 Oct 2024
I'm excited about this. If your experiments benefit from having a large field-of-view scanned fast at high resolution, this is beyond anything else out there. It's ready to go. If you want in early, email me and we'll let you know the details. No pressure. It's just very cool.
Here are a couple of shots of one of our new products. Unlocking the widest fast scanning ever. Looking forward to sharing more about this new tech! pacificoptica.com See more. Measure more.
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Spencer LaVere Smith@Labrigger21 Oct 2024
Called it.
2¹³⁶²⁷⁹⁸⁴¹−1, discovered today, is the largest known prime. It's a Mersenne prime (2ᵖ-1), which are easier to find. It took nearly 6 years for the GIMPS software to find it after the previous largest known prime. It was also the first Mersenne prime found using GPUs.
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Spencer LaVere Smith retweeted
The Diesel2p: The do-anything 2p for neuroscientists. Huge field-of-view, dual scan engines, fast, easy-to-use, and already proven in neuro labs around the world. pacificoptica.com/diesel2p/
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