Researcher in muscle cell biology. Addicted to signaling pathways (Wnt, Tgfb, Bmp). PI at Institut NeuroMyoGène.
Lyon, France
Joined April 2018
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With @GilbertLab , we designed a pipeline to study communications toward muscle stem cells during tissue regeneration. How do MuSCs re-quiesce? Check the work by our star students @GarciaPaulineJ & @Erik_Jacques_ in our new preprint.
biorxiv.org/content/10.1101/…
I am delighted to share our newest paper. @GarciaPaulineJ found that Setdb1 is absolutely required for muscle tissue regeneration. This by keeping ancient viral elements silenced in muscle stem cells. @EJPRareDiseases @iNeuroMyoGene @AfmPresse
Online now: Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation dlvr.it/T7wXZb
Fabien Le Grand retweeted
J'ai un dépôt ANR de Schrodinger🐈.
J'ai un email qui accuse réception de ma soumission, et un autre email qui me dit que ma soumission ne sera pas évalué car pas reçu.
À moins que cela soit une soumission normande🤨?
Delighted to share our latest work on BioRxiv. During her PhD, @GarciaPaulineJ relentlessly studied the impact of removing the H3K9 methyltransferase Setdb1 in muscle stem cells. Strikingly she found Setdb1 is absolutely required for regeneration 1/n
biorxiv.org/content/10.1101/…
Read our preprint, and send us your feedback 😃. We deeply thank to the funding by @EJPRareDiseases @Telethon_France and our collaborator @t_cheung .
Fabien Le Grand retweeted
Un poste de gestionnaire financier est à pourvoir au sein de l'INMG.
Découvrez l'annonce ci-dessous 👇
Fabien Le Grand retweeted
You asked for it #myotwitter and @Erik_Jacques_ delivered! A new 3D assay to study regulators of muscle stem cell quiescence and niche repopulation principles 'in a dish'. Our easiest method YET! What questions will you ask?
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Check out Nicolas Rose study, out in Biomaterials. He navigated between three labs/co-supervisors during his PhD, and yet successfully created very tiny 3D myotubes between pillars. This is a new tool to measure the force generated by a single human muscle cell in health/disease.
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Very enthusiastic to participate to the 8th Cultured Meat conference starting Sunday in Maastricht. Looking forward to learn about the latest developments on how to grow edible muscle "in a dish".
Fabien Le Grand retweeted
⚠️Only a few weeks left to register to the @humancellatlas Development and Pediatric Cell Atlas Meeting in Paris🇫🇷 . November 20 - 22, 2022 .
Fabien Le Grand retweeted
Check out our new resource paper @iScience_CP showing dramatic changes in epigenetic and transcriptomic landscapes during muscle stem cell #quiescence exit and #aging. Congrats to @AnqiDong18 and colleagues! #myotwitter
cell.com/iscience/fulltext/S…
FASEB conference on muscle satellite cells @MuSCandReg just started 😎 with @vahabsoleimani @GilbertLab @GarciaPaulineJ
LaLaurie mansion in New Orleans. The Dame was apparently a serial killer from the early 19th century. But her (rebuilt) mansion is a Hallmark of the french quarter.
This morning, I arrived 3 hours and 30 minutes at the Toronto airport before my flight for New Orleans, and missed it due to spending 3 whole hours in line for the US customs. To colleagues going to @MuSCandReg meeting tomorrow: please be more prepared than me.