Assistant Member @StJude | Transcriptional deregulation in cancer
Memphis, TN
Joined August 2014
- Tweets298
- Following481
- Followers212
- Likes1.5K
Lindsey Montefiori retweeted
1/ Most genes and variants matter somewhere but look silent in any one cell model. Can we build conditions that reveal phenotypes? With @kanishkadey, we engineer cell states to expose hidden disease biology and trace how genetic risk reaches disease genes. biorxiv.org/content/10.64898…
ALT Visual abstract: activating TFs singly and in pairs engineers new cell states, and the Mosaic model learns how TFs combine. Findings: hidden AMD risk variants, state-dependent convergence, and chromatin priming.
Lindsey Montefiori retweeted
1. CRISPR came from basic research on bacteria.
2. Optogenetics started with a discovery in algae.
3. The GFP protein comes from jellyfish.
The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
“Science isn’t broken. What is broken is the ambition level of scientists. We need to ramp that back up” -Jussi Taipale at the Bringing Chemistry to Medicine Symposium at St. Jude. 💫 stjude.org/education-trainin…
Lindsey Montefiori retweeted
I’m hiring a wet-lab Researcher/Senior Researcher at St. Jude. Hands-on training in cancer biology and opportunities to contribute to papers.
Great if you’re considering grad/med school or building a career in science. Please share!
talent.stjude.org/careers/Jo…
Let’s keep the high throughput data/experiments and still go after very good fundamental questions. We don’t have to choose, but one is certainly easier than the other
Lindsey Montefiori retweeted
September 28th we start with a new series of Erasmus Hematology Lectures. We have:
Diana Hargreaves, Emmanuelle Passague, Andrew Wei, Ruud Delwel, Ellen Rothenberg, Dan Landau, Dan Tenen, John Crispino, Kim Stegmaier and Britta Will.
Spread the news!!
Lindsey Montefiori retweeted
It's amazing how often you find actionable targets in tough cancers when you look hard enough.
We're working with a leiomyosarcoma patient, a rare abdominal cancer. This one was considered inoperable.
Lindsey Montefiori retweeted
26 years ago today, the first public assembly of the human genome went online at UC Santa Cruz. Today, we release version 500 of the UCSC Genome Browser.
From Jim Kent's first assembly to thousands of genomes, the data is still free and open.
genome.ucsc.edu/goldenPath/n…
Lindsey Montefiori retweeted
Very interesting new preprint from @jengreitz lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness.
If promoters are responsive, they respond to all enhancers.
biorxiv.org/content/10.64898…
Lindsey Montefiori retweeted
What if you could watch chromatin states change inside living neurons.....IN REAL TIME? Repost or share if you or someone you know dreams of this!
The Solecki Lab is building an imaging-based biosensor platform to make chromatin biology visible, measurable, and experimentally testable as neurons mature and wire into brain circuits (see enhancer nucleosomes fluttering below).
We’re looking for an Associate Scientist who wants to do more than run experiments. Someone who wants to help build the framework for seeing how the neuronal genome changes as the brain is built.
Lindsey Montefiori retweeted
What if a tumor could be turned against itself? 🎯
My cover for @AdvFunctMater illustrates a new approach to cancer immunotherapy 🧬
Nanoparticles deliver self-amplifying RNA into the tumor, triggering IL-12 production that recruits the body’s own immune cells and reprograms it from within 💙
🔗 doi.org/10.1002/adfm.2025294…
Lindsey Montefiori retweeted
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. doi.org/10.64898/2026.06.03.…
Lindsey Montefiori retweeted
1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
biorxiv.org/content/10.64898…
Lindsey Montefiori retweeted
Going from the discovery of epigenetic silencing of CTCF insulators nature.com/articles/s41586-0… to aberrant E-P looping cell.com/molecular-cell/full… to a successful clinical trial nature.com/articles/s41591-0… all from Brad Bernstein's lab
Lindsey Montefiori retweeted
10/ Remarkable. We are still way far from trully decyphering regulatory logic. For now, we are working with sophisticated, yet surprisingly easy-to-break, dictionaries.
Lindsey Montefiori retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Lindsey Montefiori retweeted
Just out: our forward-looking essay on mRNA “delivery cells”—engineered cells that could locally manufacture mRNA at disease sites within the body and transfer it to target cells in extracellular vesicles.
Lindsey Montefiori retweeted
Can we control cells by forcing TFs to collaborate?
Interested? Read our preprint! An awesome collaboration with @cgersbach, @christian_mcam, @IGVFConsortium, led by @Rachel_E_Savage:
biorxiv.org/content/10.64898…
🧵