Academic Head and Neck Pathologist; Specialist in HPV and Squamous Cell Carcinomas
Joined April 2017
- Tweets58
- Following16
- Followers418
- Likes8
Did you hear about the woman who grew vocal cords in the laboratory? The results speak for themselves!
Jim Lewis Jr. retweeted
A basic unit of laryngitis = 1 hoarsepower!
I just couldn't resist the pun for my buddy @LewisPath
Please share: we welcome additional applicants and look forward to learning and practicing with you all. #path_SIG
This Post is from an account that no longer exists. Learn more
We would love to see your applications, budding surgical pathologists!
This Post is from an account that no longer exists. Learn more
Thanks for a lovely example of a benign curiosity lesion.
Here is the rare massive version on CT imaging from a middle aged patient. The entire abdomen is myelipoma!
Jim Lewis Jr. retweeted
Now this is a cool diagnosis - myelolipoma. A thin rim of adrenal cortex lines an area of mature fat and hematopoietic elements. This case even had some osseous metaplasia. #PathTwitter #MSGPath
Tricky tumors when they arise in the thyroid gland because they can resemble papillary carcinoma, showing papillae, abortive nuclear irregularities like PTC, and PAX8 expression. Must look for the secretory material!
An important consideration in thyroid gland pathology: Secretory Carcinoma of the Thyroid Gland link.springer.com/article/10…
#HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #SalivaryGland #Carcinoma #PathologyTweet
This was a great event - thanks to CAP for supporting the Guidelines process and this event. @bfaquin @LewisPath #capchat @Pathologists
Thanks all for attention. The most important thing we can do as pathologists is to be consistent in what tests we do for pts with head and neck SCC. The guidelines are a start for this - and can shift in time as the field shifts. #capchat @Pathologists @bfaquin @LewisPath
Nuclear only or cytoplasmic staining only does not count, no matter the intensity or distribution - must be nuclear and cytoplasmic. For any equivocal p16 stains (borderline), your can do HPV-specific testing to resolve (RNA ISH best). #capchat @LewisPath @bfaquin @Pathologists
p16 should be positive in >70% of tumor cells, in both nucleii AND cytoplasm, and with at least moderate intensity in order to use as prognostic marker and surrogate if high risk HPV. #capchat @bfaquin @Pathologists @LewisPath
We hope that the formal CAP Evidence Based Guidelines publication would provide pathologists with the back up to insist that p16/HPV specific testing not be performed for non-oropharyngeal and non-squamous carcinomas. #capchat @AmyHDeekenMD @LewisPath @bfaquin @Pathologists
Good for you all. Is it DNA ISH or RNA ISH? Both "work" for high risk HPV detection by performance different. RNA ISH is more sensitive and specific for transcriptionally active high risk HPV. @Pathologists #capchat @bfaquin @JScapaPathMD @LewisPath
p16 should be positive in >70% of tumor cells, in both nucleii AND cytoplasm, and with at least moderate intensity in order to use as prognostic marker and surrogate if high risk HPV. #capchat @bfaquin @Pathologists @LewisPath