@london_lab

A computational and chemical biology lab at the Weizmann Institute of Science.

 Israel
weizmann.ac.il/Organic_Chemistry/London
Joined December 2015
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  • Following662
  • Followers3.6K
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Manuscript alert! I’m excited to finally share our manuscript on PINCHs, now on bioRxiv: biorxiv.org/content/10.1101/…
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These findings introduce a new paradigm in targeted protein degradation, with broad implications for chemical biology and therapeutic development. I’d welcome feedback from the community on this emerging modality.
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The work was spearheaded by Ella Livnah who almost single-handedly performed all of the experiments - herculean style, with invaluable feedback from co-corresponding author Emmanuel Levy who is a world-leader on protein symmetry and agglomeration.
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Combining covalent chemistry with proximity inducers expands their scope, and drives new discoveries. I tried to capture the state of the field in this (open access) comprehensive review. Good news - there are plenty of opportunities up for grabs :) pubs.acs.org/doi/10.1021/acs…
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We are looking forward to the 4th Virtual ChemBio Talks with a full program with keynotes @KateCarrollLab and Kai Johnsson, talks by @Malins_Lab, @london_lab, @DerbyLabDuke, Sebastian Essig and @ChellanResearch as well as our Flash Talks. Register now: web.cvent.com/event/7b3b6cdf…
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Check out the Kupcinet-Getz International Summer Program @WeizmannScience bit.ly/3VxJCXI a great opportunity to visit and get a taste of science.
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For the #covalent enthusiasts, check out the BPS "Emergence of irreversible modulation in drug discovery" meeting. Looks like a high local concentration of electrophiles :) my.bps.ac.uk/events/details/…
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Such an elegant idea from the Gray lab! Target two nucleophiles simultaneously to reduce the probability of resistance mutation formation. Dielectrophiles were previously reported, but to my knowledge not in the context of avoiding resistance. Very cool. pubs.acs.org/doi/10.1021/acs…

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

Abstract. A systematic strategy to develop dual-warhead inhibitors is introduced to circumvent the limitations of conventional covalent inhibitors such as

pubs.acs.org
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London Lab retweeted
Dan Nomura
@DanNomura29 Jan 2024
Covalent Hits and Where to Find Them - from ⁦@AstraZeneca⁩ sciencedirect.com/science/ar…
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Our recent @ScienceMagazine article has been downloaded 24,806 times! So encouraging to see so much interest in our crowdsourced, open-science effort to find an accessible and affordable #COVID19 antiviral. Here's the link in case you missed it ➡️scim.ag/4LB

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

An open-science effort yields a promising noncovalent inhibitor of the SARS-CoV-2 main protease.

science.org
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For those interested in #drugresistance check out this GRC co-chaired by @mitchell_sysbio grc.org/drug-resistance-conf…
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Replying to @XChem_DLS
@XChem_DLS and @covid_moonshot and @asap_discovery leaving deep footprints...
Protein Data Bank@PDBeurope5 Jan 2024
Replying to @PDBeurope @NatureComms @ScienceMagazine @Nature @PNASNews @ACSBioMed
More structures were solved using data collected at @DiamondLightSource in 2023 than any other synchrotron, with ~1500 entries. This was closely followed by APS (@advancedphoton) with ~1400 entries, then SSRF (Shanghai), SLS (@psich_en) and ESRF (@esrfsynchrotron). 5/10
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London Lab retweeted
EFMC@EuroMedChem11 Jan 2024
📢 Friedrich-Stolz Award Of The GDCh For outstanding commitment, scientific discovery or innovative technology that contributes to substantial therapeutic innovation. 🏆 5,000€ and a lecture at FiMC 2024. 🗓️ Submission deadline is January 31 🔗 buff.ly/47qyLV6
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The incredible @asap_discovery team members working with @XChem_DLS collected 14,631 X-ray datasets and deposited 6.7% of all X-ray structures in the PDB for ASAP in 2023 to advance structure-based antiviral discovery--with hundreds more pending release. 🚀
Slide summarizing statistics from the ASAP Structural Biology Core: Collected 14,631 datasets as of 4th December 2023. Rolling average consistently >1,000 samples/month for Q4 2023 Originally predicted ~500 samples/month 601 structures deposited in PDB by ASAP in 2023 (6.7% all X-ray structures) 924 for all of Diamond, 776 for all American synchrotrons >200 pending release

ALT Slide summarizing statistics from the ASAP Structural Biology Core: Collected 14,631 datasets as of 4th December 2023. Rolling average consistently >1,000 samples/month for Q4 2023 Originally predicted ~500 samples/month 601 structures deposited in PDB by ASAP in 2023 (6.7% all X-ray structures) 924 for all of Diamond, 776 for all American synchrotrons >200 pending release

The incredible structural biology team from ASAP standing in front of the NYC skyline wearing hoodies featuring the ASAP logo.

ALT The incredible structural biology team from ASAP standing in front of the NYC skyline wearing hoodies featuring the ASAP logo.

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