Daily news and insights on research, investments and technologies that extend life and improve the quality of that extended life. #Longevity

London
Joined December 2018
Nature Biotechnology paper offers a better way to judge models that predict gene effects. Shift plans to use it to hunt for aging targets. vist.ly/5ph3v #longevity #geroscience #NatureBiotechnology #geneeffects #aging
1
206
Insilico Medicine nominates ISM9546, an oral VAV1 degrader designed with generative AI, as a preclinical candidate for autoimmune disease. vist.ly/5pghr #longevity #geroscience #InsilicoMedicine #ISM9546 #autoimmunedisease
1
3
3
326
KAUST and Oxford researchers used a transistor-based sensor to read three forms of alpha-synuclein, reaching 90.9% accuracy in a small study. vist.ly/5pgbw #longevity #geroscience #KAUST #Oxford #alphasynuclein
1
2
380
Rona Therapeutics grants Roche worldwide rights to an ALK7-silencing candidate, with up to $1.06b in further milestones on the table. vist.ly/5pg62 #longevity #RonaTherapeutics #Roche #ALK7 #biotech
1
360
Intrinsic capacity isn’t simply fitness, independence or being disease-free. It spans cognition, locomotion, psychological and sensory capacity, and vitality, but there’s no universally accepted composite score yet. #longevity #geroscience #intrinsiccapacity
1
3
393
An up to $28.3 million ARPA-H award aims to stretch Bexorg’s human brain platform from 24 hours to two weeks. vist.ly/5pcav #longevity #geroscience #ARPAH #Bexorg #brainresearch
1
3
4
529
German biotech MODAG won for pairing a CE-marked diagnostic with a drug candidate that targets the same protein. vist.ly/5pbv5 #longevity #geroscience #MODAG #biotech #diagnostics
1
2
574
Adjusting for how advanced patients’ disease was at the start lifts the Phase 2 result. The method was added after the trial began. vist.ly/5pbbj #longevity #geroscience #Phase2 #clinicaltrial #clinicalresearch
1
3
2
427
Cala Health’s kIQ Plus now offers three stimulation modes and a calibration before each use, and it’s available across the US. vist.ly/5pb5h #longevity #CalaHealth #kIQPlus #stimulation #digitalhealth
1
1
3
506
Buck Institute’s Eric Verdin joins clinic leaders to tackle the ‘luxury diagnostic’ trap and the push for standardized care. vist.ly/5pax4 #longevity #geroscience #BuckInstitute #EricVerdin #standardizedcare
2
3
515
BodySpec’s new storefront targets muscle loss from GLP-1 weight loss drugs, with scans said to take about 12 minutes. vist.ly/5p8bg #longevity #bodyspec #muscleloss #glp1 #weightloss
2
1
6
613
VectorY is growing PIONEER-ALS from 12 to 36 participants to test VTx-002, an antibody therapy aimed at the protein TDP-43. vist.ly/5p7v2 #longevity #geroscience #vectory #pioneerals #vtx002
3
3
601
A quick digital memory test and a lab assay for brain disease are teaming up to flag neurodegeneration earlier. vist.ly/5p7h3 #longevity #geroscience #memory #braindisease #neurodegeneration
2
7
562
A Censuswide survey commissioned by PortionIQ finds confidence is lower among longer-term users, though it’s a snapshot from one brand. vist.ly/5p6x7 #longevity #censuswide #portioniq #survey #confidence
2
5
473
Forget the diagnosis count. The researcher who helped the WHO reframe aging says function, not disease, is the better yardstick. vist.ly/5p6hf #longevity #geroscience #aging #function #disease
2
2
6
575
Jupiter Neurosciences also hired an adviser to explore a sale or licensing of its assets while the 30-person trial gets underway. vist.ly/5p52r #longevity #jupiterneurosciences #trial #licensing #assets
2
4
22
1,093
The whole-body scan company is launching a research network with 50+ institutions. Early findings come with some big open questions. vist.ly/5nz9h #longevity #research #network #institutions #findings
1
5
10
696
The company added hormone therapy to its platform and released IBS results from nearly 16,000 members, with caveats attached. vist.ly/5nyzy #longevity #hormonetherapy #ibs #results #members
1
1
4
571
Monte Rosa’s NEK7-targeting drug pulled several heart-risk biomarkers toward healthy levels in 108 people with obesity. vist.ly/5nyqz #longevity #geroscience #nek7 #biomarkers #obesity
2
4
11
1,024
All three Phase 3 trials of the weekly shot ribupatide have finished enrolling, and the head-to-head against semaglutide is the one to watch. vist.ly/5nyiz #longevity #ribupatide #semaglutide #phase3 #trials
3
5
620