Core Investigator at Arc Institute and Associate Professor at UCSF
San Francisco, CA
Joined May 2019
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Cells mitigate damage to DNA in surprising ways. Using a series of CRISPRi chemogenomics screens, we identified a PRDX1-dependent iron–damage axis in the DNA damage response.
Congratulations to Tom, Abe, Shaheen, Josep and all co-authors!
doi.org/10.1038/s41589-026-0…
Interested in predictive modeling for biology? Check out Arc's 2026 Virtual Cell Challenge!
The 2026 Virtual Cell Challenge has begun! Submissions and the leaderboard are now open.
This year's task: multi-context generalization and zero-shot prediction. Models will need to predict perturbation responses in cellular contexts with no Challenge-specific training data.
arcinstitute.org/news/virtua…
LukeGilbert retweeted
it is hard to get @SKonermann to do media - she is a true lab rat - so I am excited for more of the world to hear from her directly!
Arc Co-Founder and Executive Director @SKonermann discusses what motivates her to use AI to understand complex human disease in this video from @TheAudaciousPrj.
youtube.com/watch?v=Ikc3u438…
I never thought we would be working on Vitamin E but unbiased CRISPR screens take you into unexpected biology. I am delighted to present our work on how mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-Vitamin E uptake pathway. Congratulations to Tom and all co-authors!
Paper:
sciencedirect.com/science/ar…
LukeGilbert retweeted
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: biorxiv.org/content/10.64898…
We mapped gene interactions across different environmental conditions (GxGxE) at scale for the first time in human cells. These maps lead to the realization that many genes function in a context dependent manner which provides insight into how humans have relatively few genes but many cell types. Congratulations Ben!
Paper:
cell.com/molecular-cell/full…
I am so excited to see epigenetic editing (CRISPRoff) move forward as a new approach in medicine through this clinical trial. We hope to make a difference for folks with HBV. Congratulations on a big step forward to all who made this possible!
nchromabio.com/press-release…
Invested in high content CRISPR screening and predictive models? Come to Perturb2026 (March 18/19 2026 in Vienna)! I am co-organizing this conference and am greatly looking forward to what promises to be a fantastic meeting.
perturb2026.bio/
Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace).
doi.org/10.1038/s41588-025-0…
LukeGilbert retweeted
A study out today in @NatureGenet from Core Investigator @LukeGilbertSF, @li_haolong & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
LukeGilbert retweeted
Published today in @NatureBiotech, @LaineGoudy. @LukeGilbertSF, Alex Marson, and colleagues report a new epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.
