We create hardware and software for light sheet and multiphoton microscopy, fiber photometry, brain mapping, stereology, and image analysis.

Williston, VT
Joined July 2009
We'd love to meet you at SfN 2026! Join our team at Booth #1437 in Washington, D.C., November 14-18, for a live look at SLICE 🔬, our award-winning light sheet microscope. With its compact design and intuitive workflow, SLICE brings high-resolution 3D imaging of cleared tissue within reach for labs of all sizes. Bring your questions and tell us about your research. To reserve a demo time, send us a message. See you in D.C.! 📷 Image courtesy of Kevyn Jackson and Bernice Morrow, Albert Einstein College of Medicine. #SfN2026 #LightSheetMicroscopy #Neuroscience #MBFBioscience #SfN26 #3Dimaging #sciencematters
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Join us at #SfN26, November 14–18 in Washington, D.C.! Visit Booth #1437 to meet our team, see live demos, and explore tools for imaging, acquisition, and analysis. We’d love to hear about your research! #neuroscience #SfN2026 #microscopy #sciencetools #research #sciencematters
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BIG NEWS! MBF Bioscience is excited to announce a leadership transition. Effective October 1, 2026, Veronica Pessino, PhD, was appointed CEO of MBF Bioscience. Founder Jack Glaser will continue to serve the company through efforts from the Board. Veronica joined MBF in 2025 and has served as President since January 2026. She brings a background in neuroscience research and experience leading scientific technology businesses. She will lead MBF's next chapter, with a continued focus on serving researchers through our imaging and analysis software and hardware. Jack co-founded MBF in 1988 and under his leadership, tools like Neurolucida and Stereo Investigator became standards in quantitative neuroscience. Thank you, Jack, and congratulations, Veronica.
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New research from @LMU_Muenchen found comparable anatomy learning outcomes online and in person using Histologi@, a 3D virtual slide box powered by Biolucida Viewer. Read the study: mededu.jmir.org/2026/1/e8201… #VirtualMicroscopy #MedicalEducation #AnatomyEducation #Histology #Biolucida
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As research questions get bigger and more complex, so do the experiments built to answer them. Imaging workflows increasingly span multiple instruments, real-time analysis, and decisions. We're very excited to be developing an MHS driver for ScanImage as part of the Model Hardware Standard (MHS) research preview: a new standard for AI agents to safely operate physical equipment in scientific research and advanced manufacturing. During the preview, we're testing how AI agents could support real-time data analysis and more connected imaging workflows, from acquisition through to the rest of the experiment, focusing on safety. This MHS driver is being tested as part of the research preview, it is not a shipped feature. But we're glad to be testing what these new technologies could mean for microscopy. Learn more about our work with MHS: mbfbioscience.com/mbf-biosci… Read @AnthropicAI's announcement on the MHS research preview: anthropic.com/news/model-har… #ModelHardwareStandard #ScanImage #Microscopy #ScientificImaging #Neuroscience #ArtificialIntelligence #ResearchInnovation #ImagingWorkflows #ScientificResearch #FutureOfScience #ResearchPreview
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Can the rapid antidepressant-like effects of psychedelics be separated from the side effects? New research published in Molecular Psychiatry suggests they might. Using the FP3002 Fiber Photometry System, @Yale University researchers tracked serotonin and norepinephrine activity in real time in the prefrontal cortex of mice. They found that MDMA (but not psilocybin) triggered a robust release of norepinephrine alongside serotonin. That norepinephrine appeared to suppress the classic psychedelic behavioral signature while preserving psilocybin's antidepressant-like effects. This study highlights how real-time neurochemical recording with the FP3002 Fiber Photometry System is helping researchers uncover the complex interactions between neuromodulators, advancing our understanding of brain function and supporting the development of more targeted neuropsychiatric therapies. Read the study: nature.com/articles/s41380-0… . . #Neuroscience #Neurochemistry #FiberPhotometry #BrainScience #Neuropharmacology #Research #Psychedelics
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We're here at #FENS2026! If you're attending the meeting, come visit us at Booth #154. We'd love to talk science, hear about your research, and share our latest innovations in imaging and neuroscience software.🔬🧠 We can't wait to see you! #Neuroscience #Microscopy #BrainResearch #Imaging #LifeScience #MBFBioscience
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Heading to #FENS2026 in Barcelona? Come find us at Booth #154, we'd love to show you what we've been working on. We'll have live demos of: 🔬 SLICE™ - our award-winning light sheet microscope designed for accessible, high-performance 3D imaging 🧠 FP3002 - our fiber photometry platform for recording neural activity in freely moving animals You'll also get a chance to explore our broader portfolio: neuron tracing, stereology, brain mapping, multiphoton imaging, and C. elegans behavior analysis. Our team would love to hear about your research. Stop by and say hi! 📍Booth #154 📅 6–10 July fensforum.org/ . . #Neuroscience #LightSheetMicroscopy #FiberPhotometry #BrainMapping #Stereology #MultiphotonImaging #MBFBioscience
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Featured in @naturemethods: researchers at the Max Planck Institute for Neurobiology of Behavior developed a head-mounted multiplane microscope enabling simultaneous imaging across cortical layers in freely moving mice. Using ScanImage and the high-speed vDAQ, the team recorded neuronal activity during complex behaviors. Read more: nature.com/articles/s41592-0… #multiphotonimaging #scanimage #vDAQ #mbfbioscience
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A new @NatureBiotech Research Briefing highlights hybrid solid–liquid optics and their role in scalable, high-resolution light-sheet microscopy. We're excited to see the innovations behind the award-winning SLICE benchtop light sheet microscope, developed by Dr. Raju Tomer and collaborators, continue to gain recognition. nature.com/articles/s41587-0… #lightsheetimaging #SLICElightsheetmicroscope #3Dimaging #MBFBioscience
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We're delighted to see this work highlighted by @TheBioPhotonics. HySIL and SCOPE represent exciting advances in optical design, helping deliver high-resolution 3D tissue imaging while reducing the cost and complexity traditionally associated with advanced microscopy. We're proud to have collaborated on bringing these advances to researchers through the SLICE™ Light Sheet Microscope. 📖photonics.com/Articles/Hybri… #BioPhotonics #Microscopy #Optics #LightSheetMicroscopy #slicelightsheetmicroscope #mbfbioscience #3Dimaging
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Great to see this work featured by @physorg_com. The article highlights the Nature Biotechnology publication from Dr. Raju Tomer and collaborators introducing HySIL and SCOPE, innovative optical technologies designed to make high-resolution 3D tissue imaging more accessible and scalable. These advances have also been incorporated into the SLICE™ Light Sheet Microscope, helping bring powerful 3D imaging capabilities to researchers across neuroscience, developmental biology, cancer research, and pathology. Read more: phys.org/news/2026-06-3d-mic… #LightSheetMicroscopy #3DImaging #Neuroscience #Microscopy #SLICElightsheetmicroscope #lightsheetimaging
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Hybrid solid−liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media go.nature.com/4xdDkQR
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🔬 Celebrating a breakthrough from Dr. Raju Tomer's lab @Columbia, just published in @NatureBiotech! SCOPE technology + SLICE microscopy = affordable, high-resolution 3D imaging for all. Dr. Tomer's team developed SCOPE, which transforms inexpensive air objectives into submicron-resolution tools. Combined with SLICE (which we commercialized from his pLSM invention), researchers can image centimeter-scale samples at nanoscale detail. The research team—spanning Columbia, NIH, Lehigh, NYU Langone, and MBF—demonstrated: • Whole mouse & salamander brains • Human tissue 3D histopathology • Brain organoids with microglia • Multi-immersion compatibility This collaboration shows what's possible when academic innovation meets commercial accessibility. Dr. Tomer invented the platform; we help make it available to labs worldwide. Huge congratulations to Dr. Tomer, the biologist collaborators, and the entire research team! This is the kind of science that expands what's possible for everyone. 🎉 Read the full paper: nature.com/articles/s41587-0… #Microscopy #Neuroscience #LightSheet #ScientificImaging #Innovation #SLICElightsheetmicroscope
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Attending C. elegans 2026 (MAPSS + DevCell)? Stop by our booth to see the latest in WormLab for C. elegans tracking, imaging, and behavioral analysis. Whether you're looking to improve imaging workflows or streamline behavioral studies, we'd be happy to show you what's new and discuss your research needs. Looking forward to connecting with the C. elegans community! uwmadison.eventsair.com/maps… . . #Celegans #Celegans2026 #WormLab #BehaviorAnalysis #Imaging #Neuroscience #MAPSS #DevCell2026
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We’re having a great time at the Canadian Association for Neuroscience Meeting in Montréal! We’re here today and tomorrow. If you’re attending, stop by our booth to see live demos of: 🔬 SLICE™ light sheet microscope for accessible, high-performance 3D imaging 🧠 FP3002 for flexible fiber photometry experiments 🧬 Software solutions for neuron tracing, stereology, brain mapping, multiphoton imaging, and more We’d love to hear about your research and imaging workflows and connect with more of the neuroscience community! can-acn.org/meeting-2026/ @CAN_ACN #CAN2026 #Neuroscience #LightSheetMicroscopy #FiberPhotometry #BrainMapping #Stereology #Scienceinnovation #MBFBioscience
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