@MChangGroup

Student-run account of the Michelle Chang Lab at Princeton || Synthetic Biology || Metabolic Engineering || Biocatalysis || Find us at https://xitter.cf/t.co/vY70QdSAlr

 Princeton, NJ
michellechang.chemistry.princeton.edu/
Joined June 2019
  • Tweets104
  • Following126
  • Followers1.2K
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Our lab recently made a big move - to Bluesky! Follow us at mchanggroup.bsky.social for updates like our newest preprint: chemrxiv.org/engage/chemrxiv…
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MChangGroup retweeted
Max Sosa@maxbsosa30 Sep 2024
I'm finally on my way! After a long, relaxing summer, I'm finally headed to Tokyo as a @jsps_sns Postdoctoral Fellowship. I'll spend the next few years working with Prof. Abe and the many talented scientists @UTokyo_News Lab of Natural Products Chemistry.
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Expanding chemistry through in vitro and in vivo #biocatalysis by Elijah N. Kissman, Max B. Sosa @maxbsosa, Douglas C. Millar, Edward J. Koleski, Kershanthen Thevasundaram, and Michelle C. Y. Chang @MChangGroup at @UCB_Chemistry @PrincetonChem in @Nature nature.com/articles/s41586-0…
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Check out our review on the current state of biocatalysis. Congrats to the authors. nature.com/articles/s41586-0…

Expanding chemistry through in vitro and in vivo biocatalysis

Nature - This Review considers developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

nature.com
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MChangGroup retweeted
Rittle Lab@RittleLab8 Jul 2024
Start your week off with a little manganese. @rdavbritt chemrxiv.org/engage/chemrxiv…

O2 Activation and Enzymatic C-H Bond Activation Mediated by a Dimanganese Cofactor | ChemRxiv

Dioxygen (O2) is a potent oxidant used by aerobic organisms for energy transduction and critical biosynthetic processes. Numerous metallocofactors, which most commonly feature iron or copper ions,...

chemrxiv.org
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Also, congratulations to our undergrads Jacob Leeman (@jacob_leeman), Kodi Nguyen, Claire Li, and Avery Yang for earning their undergraduate degrees!
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Big congratulations to our newly minted doctors, Dr. Max Sosa (@maxbsosa), Dr. Elijah Kissman, and Dr. Douglas Millar (@_PhDoug ).
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Big thanks to the Bay Area Chemical Biology Community for the all the great memories. We will miss everyone greatly!
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Next up, we had Andrew Michael Whitten who did a posh job with his presentation on applying ATP-Grasps to several different problems in protein bioconjugation chemistry.
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Been a very busy week for the Chang Group! First, congrats to @vstafford_ for presenting an award winning poster at the CBBA Day!
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Announcing our new @PrincetonChem and @PrincetonMSE #ssNMR #DNP instrument: fully installed at Frick Lab, ready for inspired campus research, and one of just a few instruments like it in the world. Read all about it here: bit.ly/3QR9o9p
Full-color image of the NMR Facility director sitting in his office at Frick Lab.

ALT Full-color image of the NMR Facility director sitting in his office at Frick Lab.

Full-color image of the ssNMR instrument fully installed in the basement at Frick Lab.

ALT Full-color image of the ssNMR instrument fully installed in the basement at Frick Lab.

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Congratulations to Professor Dan Suess, Professor Alison Wendlandt, and Professor Bin Zhang, who have all earned tenure effective July 1, 2024! chemistry.mit.edu/chemistry-…
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MChangGroup retweeted
The Muir Lab@MuirLab30 Apr 2024
Congratulations to our newest inductee into the @theNASciences! @PrincetonChem
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Congratulations to Assistant Professor Monica Neugebauer (@NeugMonicaElena), who is a 2024 recipient of the Shaw Early Career Research Award! The $200,000 award is sponsored by @GrMKEFdn. Learn more about Neugebauer's research: biochem.wisc.edu/2024/04/24/…

Neugebauer Receives Shaw Early Career Research Award

The award will support her lab’s exploration of biomedical applications of continuous protein evolution.

biochem.wisc.edu
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Congratulations to Professor Dan Suess, who has been named the winner of the 2024 Inorganic Chemistry Lectureship by @InorgChem! chemistry.mit.edu/chemistry-…
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Check out the published version in @angew_chem! onlinelibrary.wiley.com/doi/…

Biosynthesis of Strained Amino Acids by a PLP‐Dependent Enzyme through Cryptic Halogenation

Halogenases enable organisms to alter the reactivity of a biological substrate by enzymatically installing a leaving group. In this communication, we discover a bacterial gene cluster which uses a...

onlinelibrary.wiley.com
MChangGroup@MChangGroup14 Dec 2023
Check out our lab’s latest preprint on the biosynthesis of amino acids that feature strained rings. @maxbsosa discovered that these gene clusters contain a PLP-dependent enzyme that forms the ring from a halogenated substrate. biorxiv.org/content/10.1101/…

Biosynthesis of Strained Amino Acids Through a PLP-Dependent Enzyme via Cryptic Halogenation

Amino acids (AAs) are modular and modifiable building blocks which nature uses to synthesize both macromolecules, such as proteins, and small molecule natural products, such as alkaloids and non-ri...

biorxiv.org
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Read about an amazing new cryo-ET data processing tool developed by @barrettmpowell from the @jhdavislab! Check out my news article on this work and the publication out now in Nature Methods. biology.mit.edu/davis-lab-ex… nature.com/articles/s41592-0…

News brief: Davis Lab - MIT Department of Biology

New software allows scientists to model shapeshifting proteins in native cellular environments Cells rely on complex molecular machines composed of protein assemblies to perform essential functions...

biology.mit.edu
MIT Biology@MITBiology8 Mar 2024
From @AlisonBiester reporting on the @jhdavislab, new software allows scientists to model shapeshifting proteins in native cellular environments biology.mit.edu/davis-lab-ex…

News brief: Davis Lab - MIT Department of Biology

New software allows scientists to model shapeshifting proteins in native cellular environments Cells rely on complex molecular machines composed of protein assemblies to perform essential functions...

biology.mit.edu
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So pleased to post this @ChristheChang paper, now out in @Nature: "Oxidative cyclization reagents reveal tryptophan cation–π interactions." Congratulations Chris Chang Lab and all! Full paper: bit.ly/4a2oLmF
Illustrative graphic from the journal Nature.

ALT Illustrative graphic from the journal Nature.

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Don't miss this excellent @ChemistryWorld piece, it features a #ChemSciHOT🔥article from the group of @ChemicalScience Associate Editor Michelle Chang @MChangGroup! 'E. coli rewired to shift carbon flow towards C4 chemicals' chemistryworld.com/news/e-co…

E. coli rewired to shift carbon flow towards C4 chemicals

Bioengineering strategy creates evolutionary advantage linking cell growth with product formation

chemistryworld.com
Chemistry World@ChemistryWorld30 Jan 2024
Leveraging the ability of living systems to evolve and overcome complex problems, researchers from @UCBerkeley have created strains of Escherichia coli capable of anaerobically producing n-butanol, 1,3-butanediol and 4-hydroxy-2-butanone. chemistryworld.com/news/e-co…

E. coli rewired to shift carbon flow towards C4 chemicals

Bioengineering strategy creates evolutionary advantage linking cell growth with product formation

chemistryworld.com
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