Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.
Joined April 2020
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Just out: Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Great collaborative effort between @OtagoPharmacy @joel_tyndall , @OtagoBiochemist and @otago Chemistry
doi.org/10.1002/cmdc.2024003…
New @BiochemistryACS paper about one of my favorite enzymes ever - Structural, Spectroscopic, and Computational Insights of the Ethylene-Forming Enzyme. Collaboration between @MSU_BMB @michigantech and myself at @OtagoBiochemist doi.org/10.1021/acs.biochem.…
Structures just released
rcsb.org/structure/8T87
rcsb.org/structure/8T88
determined in collaboration with @Stanford @mbogyo and my lab at @OtagoBiochemist - JACS paper on Probes for Specific Detection of Staph Infections
doi.org/10.1021/jacs.3c13974 @JeyunJo @TulsiUpadhyay5 +others
One week left to apply #postdoc #position in #biochemistry on #research into #peptide & #enzyme via #phage in ##infectiousdisease at #university @OtagoBiochemist in #NewZealand and #Shanghai #SIMM
Details: otago.taleo.net/careersectio…
We are looking for a Postdoctoral Fellow to create peptide tools for the treatment & diagnosis of infectious diseases at the University of Otago & Shanghai Institute of Materia Medica.
Funded by New Zealand Maurice Wilkins Centre Starting September
Details otago.taleo.net/careersectio…
Newly discovered #Staphylococcus aureus serine hydrolase probe and drug targets
pub.iapchem.org/ojs/index.ph…
My latest review of ten S. aureus protein targets for probe & drug development. Looking forward to new advances @mbogyo @ChristianSLentz and myself @OtagoBiochemist.
Excited to share my latest paper in #JournalofLifeSciences on #Cesium binding in #protein #crystals based on work between @MSU_NatSci and @OtagoBiochemist
doi.org/10.36069/JoLS/202103…
Consider #caesium in your #crystallography experiments to improve #diffraction or solve #phases.
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity
doi.org/10.1042/BCJ20200793
Our latest work hot off the press from @OtagoBiochemist. Thanks @parakra, KD, @ItamarKass, @gnljameson, SMW & @Liz_Ledgerwood
doi.org/10.3390/ijms21217837
Our latest review @OtagoBiochemist Thanks Cameron, Abigail & @MacePeter: Molecular Regulation of the Polycomb Repressive-Deubiquitinase. A really good read. #GeneTranscription #deubiquitinase #protease #structure #Drosophila
doi.org/10.1038/s41598-020-7…
Excited to share the latest collaboration with Benoît Desguin, bacteria can be amazing! Uncovering a superfamily of nickel‑dependent hydroxyacid racemases and epimerases. Looking forward to new discoveries with @UCLouvain_ADRE @MSU_NatSci @OtagoBiochemist
